Diminished expression of ICOS, GITR and CTLA-4 at the mRNA level in T regulatory cells of children with newly diagnosed type 1 diabetes

Diabetes mellitus is one of the most common chronic diseases in children. T regulatory cells (Tregs) modulate response to autoantigens and probably play a role in pathogenesis of type 1 diabetes (T1DM). The aim of the present study was the assessment of T regulatory cells including their percentages...

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Veröffentlicht in:	Acta biochimica Polonica 2009-01, Vol.56 (2), p.361-370
Hauptverfasser:	Łuczyński, Włodzimierz, Wawrusiewicz-Kurylonek, Natalia, Stasiak-Barmuta, Anna, Urban, Remigiusz, Iłendo, Elzbieta, Urban, Mirosława, Hryszko, Marek, Kretowski, Adam, Górska, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antigens, CD - genetics Antigens, CD - isolation & purification Antigens, Differentiation, T-Lymphocyte - genetics Autoimmunity - genetics Child CTLA-4 Antigen Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - immunology Female Flow Cytometry Gene Expression Glucocorticoid-Induced TNFR-Related Protein - genetics Humans Inducible T-Cell Co-Stimulator Protein Interleukin-23 - genetics Interleukins - genetics Lymphocyte Count Male Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Smad3 Protein - genetics Statistics, Nonparametric T-Lymphocyte Subsets T-Lymphocytes, Regulatory - metabolism
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