A Summary of Preclinical Topical Microbicide Vaginal Safety and Chlamydial Efficacy Evaluations in a Pigtailed Macaque Model

Background: The development of topical microbicides represents a new and exciting field in the prevention of sexually transmitted diseases, and it is especially important that candidate products undergo rigorous preclinical safety and efficacy testing before advancing to clinical trials. Methods: We...

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Veröffentlicht in:	Sexually transmitted diseases 2008-10, Vol.35 (10), p.889-897
Hauptverfasser:	PATTON, DOROTHY L., SWEENEY, YVONNE T. COSGROVE, PAUL, KATHLEEN J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravaginal Animals Anti-Infective Agents, Local - administration & dosage Anti-Infective Agents, Local - adverse effects Anti-Infective Agents, Local - pharmacology Anti-Infective Agents, Local - therapeutic use Biological and medical sciences Chlamydia Chlamydia - drug effects Chlamydia Infections - drug therapy Chlamydia Infections - prevention & control Disease control Disease Models, Animal Disease prevention Drug Evaluation, Preclinical Epidemiology. Vaccinations Female General aspects Human immunodeficiency virus Human infectious diseases. Experimental studies and models Infectious diseases Macaca Macaca nemestrina Medical research Medical sciences Monkeys & apes Primates Sexually Transmitted Diseases - drug therapy Sexually Transmitted Diseases - prevention & control Treatment Outcome Vagina - drug effects
Online-Zugang:	Volltext
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