Spontaneous Vascular Neoplasms in Aged Sprague-Dawley Rats
Primary benign and malignant vascular neoplasms occurred spontaneously in 8 of 710 male (1.1%) and 4 of 710 female (0.6%) CrI:CD®Br strain Sprague-Dawley rats employed in two 2-yr oncogenicity studies (1,400) and as controls in a 1-yr toxicity study (20). Four of 13 neoplasms were found in the splee...
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| Veröffentlicht in: | Toxicologic pathology 1995-07, Vol.23 (4), p.518-526 |
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| creator | Zwicker, Gary M. Eyster, Randy C. Sells, Donald M. Gass, Jerome H. |
| description | Primary benign and malignant vascular neoplasms occurred spontaneously in 8 of 710 male (1.1%) and 4 of 710 female (0.6%) CrI:CD®Br strain Sprague-Dawley rats employed in two 2-yr oncogenicity studies (1,400) and as controls in a 1-yr toxicity study (20). Four of 13 neoplasms were found in the spleen; skin and kidney each had 2 neoplasms. Single vascular neoplasms were in the liver, testicle, uterus, mesenteric lymph node, and vagina. Hemangioma was more common (5 males, 2 females) than hemangiosarcoma (3 males, 2 females). Vascular neoplasms were considered the cause of death in 2 females, both with hemangiosarcomas involving the spleen or kidney. One male had 2 primary hemangiomas in separate organs. Vascular neoplasms are infrequently reported [1/82 females (1.2%), 1961; 9/880 both sexes (1.0%), 1985] in this rat strain. The incidence of vascular neoplasms of this report was higher in males (9) than in females (4), in contrast to incidences reported in the literature. |
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Four of 13 neoplasms were found in the spleen; skin and kidney each had 2 neoplasms. Single vascular neoplasms were in the liver, testicle, uterus, mesenteric lymph node, and vagina. Hemangioma was more common (5 males, 2 females) than hemangiosarcoma (3 males, 2 females). Vascular neoplasms were considered the cause of death in 2 females, both with hemangiosarcomas involving the spleen or kidney. One male had 2 primary hemangiomas in separate organs. Vascular neoplasms are infrequently reported [1/82 females (1.2%), 1961; 9/880 both sexes (1.0%), 1985] in this rat strain. The incidence of vascular neoplasms of this report was higher in males (9) than in females (4), in contrast to incidences reported in the literature.</description><identifier>ISSN: 0192-6233</identifier><identifier>EISSN: 1533-1601</identifier><identifier>DOI: 10.1177/019262339502300409</identifier><identifier>PMID: 7501964</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Aging ; Animal tumors. Experimental tumors ; Animals ; Biological and medical sciences ; Female ; Hemangioma - pathology ; Hemangioma - physiopathology ; Hemangiosarcoma - pathology ; Hemangiosarcoma - physiopathology ; Male ; Medical sciences ; Rats ; Rats, Sprague-Dawley ; Spontaneous animal tumors ; Tumors ; Vascular Neoplasms - pathology ; Vascular Neoplasms - physiopathology</subject><ispartof>Toxicologic pathology, 1995-07, Vol.23 (4), p.518-526</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-2a6fed7b6b38a8f61be927ec7da7bf95e8bc20f4ecc4fd9043f38b2d3c92f0eb3</citedby><cites>FETCH-LOGICAL-c465t-2a6fed7b6b38a8f61be927ec7da7bf95e8bc20f4ecc4fd9043f38b2d3c92f0eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/019262339502300409$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/019262339502300409$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3628035$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7501964$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zwicker, Gary M.</creatorcontrib><creatorcontrib>Eyster, Randy C.</creatorcontrib><creatorcontrib>Sells, Donald M.</creatorcontrib><creatorcontrib>Gass, Jerome H.</creatorcontrib><title>Spontaneous Vascular Neoplasms in Aged Sprague-Dawley Rats</title><title>Toxicologic pathology</title><addtitle>Toxicol Pathol</addtitle><description>Primary benign and malignant vascular neoplasms occurred spontaneously in 8 of 710 male (1.1%) and 4 of 710 female (0.6%) CrI:CD®Br strain Sprague-Dawley rats employed in two 2-yr oncogenicity studies (1,400) and as controls in a 1-yr toxicity study (20). Four of 13 neoplasms were found in the spleen; skin and kidney each had 2 neoplasms. Single vascular neoplasms were in the liver, testicle, uterus, mesenteric lymph node, and vagina. Hemangioma was more common (5 males, 2 females) than hemangiosarcoma (3 males, 2 females). Vascular neoplasms were considered the cause of death in 2 females, both with hemangiosarcomas involving the spleen or kidney. One male had 2 primary hemangiomas in separate organs. Vascular neoplasms are infrequently reported [1/82 females (1.2%), 1961; 9/880 both sexes (1.0%), 1985] in this rat strain. The incidence of vascular neoplasms of this report was higher in males (9) than in females (4), in contrast to incidences reported in the literature.</description><subject>Aging</subject><subject>Animal tumors. Experimental tumors</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Hemangioma - pathology</subject><subject>Hemangioma - physiopathology</subject><subject>Hemangiosarcoma - pathology</subject><subject>Hemangiosarcoma - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Spontaneous animal tumors</subject><subject>Tumors</subject><subject>Vascular Neoplasms - pathology</subject><subject>Vascular Neoplasms - physiopathology</subject><issn>0192-6233</issn><issn>1533-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKw0AUhgdRaq2-gCBkIbiKnUtmJnFX6hWKglW3YTI5U1JycyZB-vZOSehGcHUW__efc_gQuiT4lhAp55gkVFDGEo4pwzjCyRGaEs5YSAQmx2i6B8I9cYrOnNtiTGIS4QmaSO4jEU3R3bpt6k7V0PQu-FJO96WywSs0balc5YKiDhYbyIN1a9Wmh_Be_ZSwC95V587RiVGlg4txztDn48PH8jlcvT29LBerUEeCdyFVwkAuM5GxWMVGkAwSKkHLXMnMJBziTFNsItA6MnmCI2ZYnNGc6YQaDBmboZthb2ub7x5cl1aF01CWw9ep5JwwGWPmSTqQ2jbOWTBpa4tK2V1KcLo3lv415ktX4_o-qyA_VEZFPr8ec29HlcaqWhfugDFB_WnusfmAObWBdNv0tvZS_jv8C6pVf_0</recordid><startdate>19950701</startdate><enddate>19950701</enddate><creator>Zwicker, Gary M.</creator><creator>Eyster, Randy C.</creator><creator>Sells, Donald M.</creator><creator>Gass, Jerome H.</creator><general>SAGE Publications</general><general>Sage</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19950701</creationdate><title>Spontaneous Vascular Neoplasms in Aged Sprague-Dawley Rats</title><author>Zwicker, Gary M. ; Eyster, Randy C. ; Sells, Donald M. ; Gass, Jerome H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-2a6fed7b6b38a8f61be927ec7da7bf95e8bc20f4ecc4fd9043f38b2d3c92f0eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Aging</topic><topic>Animal tumors. Experimental tumors</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Hemangioma - pathology</topic><topic>Hemangioma - physiopathology</topic><topic>Hemangiosarcoma - pathology</topic><topic>Hemangiosarcoma - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Spontaneous animal tumors</topic><topic>Tumors</topic><topic>Vascular Neoplasms - pathology</topic><topic>Vascular Neoplasms - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zwicker, Gary M.</creatorcontrib><creatorcontrib>Eyster, Randy C.</creatorcontrib><creatorcontrib>Sells, Donald M.</creatorcontrib><creatorcontrib>Gass, Jerome H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicologic pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zwicker, Gary M.</au><au>Eyster, Randy C.</au><au>Sells, Donald M.</au><au>Gass, Jerome H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spontaneous Vascular Neoplasms in Aged Sprague-Dawley Rats</atitle><jtitle>Toxicologic pathology</jtitle><addtitle>Toxicol Pathol</addtitle><date>1995-07-01</date><risdate>1995</risdate><volume>23</volume><issue>4</issue><spage>518</spage><epage>526</epage><pages>518-526</pages><issn>0192-6233</issn><eissn>1533-1601</eissn><abstract>Primary benign and malignant vascular neoplasms occurred spontaneously in 8 of 710 male (1.1%) and 4 of 710 female (0.6%) CrI:CD®Br strain Sprague-Dawley rats employed in two 2-yr oncogenicity studies (1,400) and as controls in a 1-yr toxicity study (20). Four of 13 neoplasms were found in the spleen; skin and kidney each had 2 neoplasms. Single vascular neoplasms were in the liver, testicle, uterus, mesenteric lymph node, and vagina. Hemangioma was more common (5 males, 2 females) than hemangiosarcoma (3 males, 2 females). Vascular neoplasms were considered the cause of death in 2 females, both with hemangiosarcomas involving the spleen or kidney. One male had 2 primary hemangiomas in separate organs. Vascular neoplasms are infrequently reported [1/82 females (1.2%), 1961; 9/880 both sexes (1.0%), 1985] in this rat strain. The incidence of vascular neoplasms of this report was higher in males (9) than in females (4), in contrast to incidences reported in the literature.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>7501964</pmid><doi>10.1177/019262339502300409</doi><tpages>9</tpages></addata></record> |
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| ispartof | Toxicologic pathology, 1995-07, Vol.23 (4), p.518-526 |
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| subjects | Aging Animal tumors. Experimental tumors Animals Biological and medical sciences Female Hemangioma - pathology Hemangioma - physiopathology Hemangiosarcoma - pathology Hemangiosarcoma - physiopathology Male Medical sciences Rats Rats, Sprague-Dawley Spontaneous animal tumors Tumors Vascular Neoplasms - pathology Vascular Neoplasms - physiopathology |
| title | Spontaneous Vascular Neoplasms in Aged Sprague-Dawley Rats |
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