Epigenetic modulation of PTEN expression during antiandrogenic therapies in human prostate cancer

Although the tumor-suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is frequently mutated or deleted in a wide variety of solid tumors, some malignancies, including prostate cancer, exhibit undetectable PTEN protein without loss of PTEN gene. Aim of this study was to evaluat...

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Veröffentlicht in:	International journal of oncology 2009-11, Vol.35 (5), p.1133-1139
Hauptverfasser:	LUCA GRAVINA, Giovanni, BIORDI, Leda, MARTELLA, Francesco, FLATI, Vincenzo, RICEVUTO, Enrico, FICORELLA, Corrado, TOMBOLINI, Vincenzo, FESTUCCIA, Claudio
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen Antagonists - therapeutic use Apoptosis - drug effects Azacitidine - therapeutic use Biological and medical sciences Blotting, Western Cells, Cultured Epigenesis, Genetic - drug effects Gene Expression - drug effects Humans Male Medical sciences Nephrology. Urinary tract diseases Polymerase Chain Reaction Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics PTEN Phosphohydrolase - biosynthesis PTEN Phosphohydrolase - genetics Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Tumors Tumors of the urinary system Urinary tract. Prostate gland Valproic Acid - therapeutic use
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