CCR7 and CXCR4 expression predicts lymph node status including micrometastasis in gastric cancer

The chemokine receptors CCR7 and CXCR4 play a major role in the mechanism of lymph node metastasis from primary tumor cells. We postulated that their expression in gastric tumor cells could predict lymph node status including lymph node micrometastasis (LNMM). We assessed CCR7 and CXCR4 expression i...

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Veröffentlicht in:	International journal of oncology 2009-07, Vol.35 (1), p.19-24
Hauptverfasser:	ARIGAMI, Takaaki, NATSUGOE, Shoji, UENOSONO, Yoshikazu, YANAGITA, Shigehiro, ARIMA, Hideo, HIRATA, Munetsugu, ISHIGAMI, Sumiya, AIKOU, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Cell Line, Tumor Female Gastrectomy Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Keratins - analysis Lymph Node Excision Lymphatic Metastasis Male Medical sciences Middle Aged Predictive Value of Tests Receptors, CCR7 - analysis Receptors, CCR7 - genetics Receptors, CXCR4 - analysis Receptors, CXCR4 - genetics Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Stomach Neoplasms - genetics Stomach Neoplasms - immunology Stomach Neoplasms - secondary Stomach Neoplasms - surgery Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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