Induction of Lung Lesions in Female Rats Following Chronic Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin

2,3,7,8,-Tetrachlorodibenzo- p-dioxin (TCDD) has been classified as a known human carcinogen, and epidemiologic studies identify the lung as one of the target organs. Few experimental studies have attempted to characterize pulmonary effects of TCDD exposure. In this study, we characterize the induct...

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Veröffentlicht in:	Toxicologic pathology 2000-11, Vol.28 (6), p.761-769
Hauptverfasser:	Tritscher, Angelika M., Mahler, Joel, Portier, Christopher J., Lucier, George W., Walker, Nigel J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - chemically induced Adenoma - pathology Age Factors Animals Biological and medical sciences Bronchi - drug effects Bronchi - metabolism Bronchi - pathology Carcinogenicity Tests Carcinogens - administration & dosage Carcinogens - pharmacokinetics Carcinogens - toxicity Carcinoma - chemically induced Carcinoma - pathology Chemical and industrial products toxicology. Toxic occupational diseases Cytochrome P-450 CYP1A1 - metabolism Diethylnitrosamine - toxicity Drug Administration Schedule Female Half-Life Hyperplasia Lung Neoplasms - chemically induced Lung Neoplasms - metabolism Lung Neoplasms - pathology Medical sciences Metaplasia Polychlorinated Dibenzodioxins - administration & dosage Polychlorinated Dibenzodioxins - toxicity Precancerous Conditions - chemically induced Precancerous Conditions - metabolism Precancerous Conditions - pathology Pulmonary Alveoli - drug effects Pulmonary Alveoli - metabolism Pulmonary Alveoli - pathology Rats Rats, Sprague-Dawley Receptors, Aryl Hydrocarbon - metabolism Respiratory Mucosa - drug effects Respiratory Mucosa - metabolism Respiratory Mucosa - pathology Tissue Distribution Toxicology Various organic compounds
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