Spontaneous Corneal Dystrophy and Generalized Basement Membrane Changes in Fischer-344 Rats
Groups of young, sexually mature Fischer-344 rats (n = 25/sex) obtained from 3 commercial breeders were examined ophthalmologically and histopathologically to determine the prevalence and severity of corneal basement membrane lesions (corneal dystrophy) and basement membrane changes in select nonocu...
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| Veröffentlicht in: | Toxicologic pathology 1992-01, Vol.20 (3-1), p.357-366 |
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| container_title | Toxicologic pathology |
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| creator | Bruner, Richard H. Keller, Waldo F. Stitzel, Katherine A. Sauers, Leonard J. Reer, Paul J. Long, Philip H. Bruce, Robert D. Alden, Carl L. |
| description | Groups of young, sexually mature Fischer-344 rats (n = 25/sex) obtained from 3 commercial breeders were examined ophthalmologically and histopathologically to determine the prevalence and severity of corneal basement membrane lesions (corneal dystrophy) and basement membrane changes in select nonocular tissues. Results disclosed a high incidence of corneal basement membrane dystrophy in rats of both sexes from all breeders; however, severity levels were significantly increased in rats obtained from one breeder when compared to others. Furthermore, rats that displayed the most advanced corneal lesions also exhibited more severe basement membrane changes in other organs, especially renal tubules and vascular internal laminae. These findings suggest that both ocular and nonocular dystrophic changes may have been linked through common physiologic (or genetic) mechanisms. Animals that displayed basement membrane lesions were not considered to represent compromised biologic test systems. |
| doi_str_mv | 10.1177/019262339202000306 |
| format | Article |
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Results disclosed a high incidence of corneal basement membrane dystrophy in rats of both sexes from all breeders; however, severity levels were significantly increased in rats obtained from one breeder when compared to others. Furthermore, rats that displayed the most advanced corneal lesions also exhibited more severe basement membrane changes in other organs, especially renal tubules and vascular internal laminae. These findings suggest that both ocular and nonocular dystrophic changes may have been linked through common physiologic (or genetic) mechanisms. 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Animals that displayed basement membrane lesions were not considered to represent compromised biologic test systems.</description><subject>Animals</subject><subject>Basement Membrane - pathology</subject><subject>Biological and medical sciences</subject><subject>Blood Vessels - pathology</subject><subject>Corneal Diseases - pathology</subject><subject>Diseases of cornea, anterior segment and sclera</subject><subject>Female</subject><subject>Kidney - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Ophthalmology</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Stomach - pathology</subject><issn>0192-6233</issn><issn>1533-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMlOwzAQhi0EgrK8ABKSDwhOgXG8JD5CoYAEQmI5cYjcZEyDEqfY6aE8Pa5SwQGJ0xzm-2f5CDlkcMZYlp0D06lKOdcppADAQW2QEZOcJ0wB2ySjFZCsiB2yG8IHAMuZgG2yzVItQakReXued643DrtFoOPOOzQNvVqG3nfz2ZIaV9EbdOhNU39hRS9NwBZdTx-wnfoYo-OZce8YaO3opA7lDH3ChaBPpg_7ZMuaJuDBuu6R18n1y_g2uX-8uRtf3CelELxPKi2tsZZLm-YWuZ1WWTkFE6tKrVaZNjkaBTlysJnCMmOKi1JXMpd5Jbnge-R0mDv33ecCQ1-08RJsmuGtIpOScaW4iuTJ_yQXmgHoCKYDWPouBI-2mPu6NX5ZMChW7ou_7mPoaD19MW2x-o0MsmP_eN03oTSNjf7KOvxgIl6oYPXO-YAF847FR7fwLtr7b_E3VB6YKg</recordid><startdate>19920101</startdate><enddate>19920101</enddate><creator>Bruner, Richard H.</creator><creator>Keller, Waldo F.</creator><creator>Stitzel, Katherine A.</creator><creator>Sauers, Leonard J.</creator><creator>Reer, Paul J.</creator><creator>Long, Philip H.</creator><creator>Bruce, Robert D.</creator><creator>Alden, Carl L.</creator><general>SAGE Publications</general><general>Sage</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19920101</creationdate><title>Spontaneous Corneal Dystrophy and Generalized Basement Membrane Changes in Fischer-344 Rats</title><author>Bruner, Richard H. ; Keller, Waldo F. ; Stitzel, Katherine A. ; Sauers, Leonard J. ; Reer, Paul J. ; Long, Philip H. ; Bruce, Robert D. ; Alden, Carl L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-d95faff35f28fe3fbd7cb0afbd62f9679a8ea608e30f76ec71634c9d5858d5343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Basement Membrane - pathology</topic><topic>Biological and medical sciences</topic><topic>Blood Vessels - pathology</topic><topic>Corneal Diseases - pathology</topic><topic>Diseases of cornea, anterior segment and sclera</topic><topic>Female</topic><topic>Kidney - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Ophthalmology</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Stomach - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bruner, Richard H.</creatorcontrib><creatorcontrib>Keller, Waldo F.</creatorcontrib><creatorcontrib>Stitzel, Katherine A.</creatorcontrib><creatorcontrib>Sauers, Leonard J.</creatorcontrib><creatorcontrib>Reer, Paul J.</creatorcontrib><creatorcontrib>Long, Philip H.</creatorcontrib><creatorcontrib>Bruce, Robert D.</creatorcontrib><creatorcontrib>Alden, Carl L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicologic pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bruner, Richard H.</au><au>Keller, Waldo F.</au><au>Stitzel, Katherine A.</au><au>Sauers, Leonard J.</au><au>Reer, Paul J.</au><au>Long, Philip H.</au><au>Bruce, Robert D.</au><au>Alden, Carl L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spontaneous Corneal Dystrophy and Generalized Basement Membrane Changes in Fischer-344 Rats</atitle><jtitle>Toxicologic pathology</jtitle><addtitle>Toxicol Pathol</addtitle><date>1992-01-01</date><risdate>1992</risdate><volume>20</volume><issue>3-1</issue><spage>357</spage><epage>366</epage><pages>357-366</pages><issn>0192-6233</issn><eissn>1533-1601</eissn><abstract>Groups of young, sexually mature Fischer-344 rats (n = 25/sex) obtained from 3 commercial breeders were examined ophthalmologically and histopathologically to determine the prevalence and severity of corneal basement membrane lesions (corneal dystrophy) and basement membrane changes in select nonocular tissues. 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| fulltext | fulltext |
| identifier | ISSN: 0192-6233 |
| ispartof | Toxicologic pathology, 1992-01, Vol.20 (3-1), p.357-366 |
| issn | 0192-6233 1533-1601 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_755136636 |
| source | MEDLINE; SAGE Complete; Alma/SFX Local Collection |
| subjects | Animals Basement Membrane - pathology Biological and medical sciences Blood Vessels - pathology Corneal Diseases - pathology Diseases of cornea, anterior segment and sclera Female Kidney - pathology Male Medical sciences Ophthalmology Rats Rats, Inbred F344 Stomach - pathology |
| title | Spontaneous Corneal Dystrophy and Generalized Basement Membrane Changes in Fischer-344 Rats |
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