Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells

Histone deacetylase inhibitors (HDACIs) are involved in cell growth, apoptosis and differentiation. This study aimed to investigate the effects of HDACI scriptaid on histone modification, demethylation, cell growth, cell cycle and apoptosis in the RKO colorectal cancer cell line and screening for sc...

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Veröffentlicht in:	International journal of oncology 2008-10, Vol.33 (4), p.767-776
Hauptverfasser:	EUN JU LEE, BO BIN LEE, KIM, Soon-Ja, PARK, Yong-Doo, PARK, Joobae, KIM, Duk-Hwan
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Azacitidine - analogs & derivatives Azacitidine - pharmacology Biological and medical sciences Cell Cycle Cell Line, Tumor Cell Proliferation Colonic Neoplasms - drug therapy Colonic Neoplasms - genetics DNA Methylation Enzyme Inhibitors - pharmacology Epigenesis, Genetic Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Neoplastic Genes, p16 Histone Deacetylase Inhibitors Humans Hydroxylamines - pharmacology Medical sciences Promoter Regions, Genetic Quinolines - pharmacology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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