Streptococcus pyogenes SpyCEP: a chemokine-inactivating protease with unique structural and biochemical features

SpyCEP is a 170-kDa multidomain serine protease expressed on the surface of the human pathogen Streptococcus pyogenes, which plays an important role in infection by catalyzing cleavage and inactivation of the neutrophil chemoatractant interleukin-8. In this study, we investigated the biochemical fea...

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Veröffentlicht in:	The FASEB journal 2010-08, Vol.24 (8), p.2839-2848
Hauptverfasser:	Zingaretti, Chiara, Falugi, Fabiana, Nardi-Dei, Vincenzo, Pietrocola, Giampiero, Mariani, Massimo, Liberatori, Sabrina, Gallotta, Marilena, Tontini, Marta, Tani, Chiara, Speziale, Pietro, Grandi, Guido, Margarit, Immaculada
Format:	Artikel
Sprache:	eng
Schlagworte:	Cloning, Molecular Escherichia coli group A Streptococcus Humans IL‐8 cleavage Peptide Fragments - chemistry Peptide Hydrolases - chemistry Recombinant Proteins ScpC serine protease Streptococcus pyogenes
Online-Zugang:	Volltext
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