Anti-Inflammatory Effect of Maraviroc in an HIV-Infected Patient With Concomitant Myositis: A Case Report
We report the surprising yet sought impact that an antiretroviral (ARV) regimen containing maraviroc had on an HIV-infected and heavily highly active antiretroviral therapy (HAART)-experienced patient with chronic polymyositis. The patient had elevated creatine kinase (CK) levels in serum for 6 year...
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| Veröffentlicht in: | Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Ill. : 2002), 2010-07, Vol.9 (4), p.201-202 |
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| container_title | Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) |
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| creator | Capetti, Amedeo F. Pocaterra, Daria Zucchi, Patrizia Carenzi, Laura Rizzardini, Giuliano |
| description | We report the surprising yet sought impact that an antiretroviral (ARV) regimen containing maraviroc had on an HIV-infected and heavily highly active antiretroviral therapy (HAART)-experienced patient with chronic polymyositis. The patient had elevated creatine kinase (CK) levels in serum for 6 years, reaching peaks over 900 U/L and showing only partial response to high-dose steroids, not responding to HAART withdrawal. The disease started while on second-line HAART and gradually impaired his muscular function, leading to the absolute loss of the ability to stand on his legs. Atherosclerosis and hypertension contributed to the development of myocardial infarction. The association of unboosted atazanavir (ATV) plus maraviroc was designed hoping in a protective role on the cardiovascular system and in an anti-inflammatory effect that some authors have hypothesized. After only 3 months the patient’s CK levels had normalized and with the help of rehabilitation he recovered the ability to walk, which he still maintains at the one year of observation. |
| doi_str_mv | 10.1177/1545109710372671 |
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The patient had elevated creatine kinase (CK) levels in serum for 6 years, reaching peaks over 900 U/L and showing only partial response to high-dose steroids, not responding to HAART withdrawal. The disease started while on second-line HAART and gradually impaired his muscular function, leading to the absolute loss of the ability to stand on his legs. Atherosclerosis and hypertension contributed to the development of myocardial infarction. The association of unboosted atazanavir (ATV) plus maraviroc was designed hoping in a protective role on the cardiovascular system and in an anti-inflammatory effect that some authors have hypothesized. After only 3 months the patient’s CK levels had normalized and with the help of rehabilitation he recovered the ability to walk, which he still maintains at the one year of observation.</description><identifier>ISSN: 1545-1097</identifier><identifier>ISSN: 2325-9574</identifier><identifier>EISSN: 1557-0886</identifier><identifier>EISSN: 2325-9582</identifier><identifier>DOI: 10.1177/1545109710372671</identifier><identifier>PMID: 20798399</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Aged ; Anti-Inflammatory Agents - administration & dosage ; Anti-Inflammatory Agents - therapeutic use ; Antiretroviral drugs ; Antiretroviral therapy ; Antiretroviral Therapy, Highly Active ; Blood pressure ; Case reports ; Chronic Disease ; Creatine Kinase - blood ; Cyclohexanes - administration & dosage ; Cyclohexanes - therapeutic use ; Drug abuse ; HIV ; HIV Fusion Inhibitors - administration & dosage ; HIV Fusion Inhibitors - therapeutic use ; HIV Infections - complications ; HIV Infections - drug therapy ; HIV Infections - virology ; Hormones ; Human immunodeficiency virus ; Humans ; Hypertension ; Inflammatory diseases ; Male ; Musculoskeletal diseases ; Myositis - complications ; Myositis - drug therapy ; Patients ; Prescription drugs ; Rehabilitation ; Treatment Outcome ; Triazoles - administration & dosage ; Triazoles - therapeutic use</subject><ispartof>Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002), 2010-07, Vol.9 (4), p.201-202</ispartof><rights>The Author(s) 2010</rights><rights>The Author(s) 2010. 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| subjects | Aged Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - therapeutic use Antiretroviral drugs Antiretroviral therapy Antiretroviral Therapy, Highly Active Blood pressure Case reports Chronic Disease Creatine Kinase - blood Cyclohexanes - administration & dosage Cyclohexanes - therapeutic use Drug abuse HIV HIV Fusion Inhibitors - administration & dosage HIV Fusion Inhibitors - therapeutic use HIV Infections - complications HIV Infections - drug therapy HIV Infections - virology Hormones Human immunodeficiency virus Humans Hypertension Inflammatory diseases Male Musculoskeletal diseases Myositis - complications Myositis - drug therapy Patients Prescription drugs Rehabilitation Treatment Outcome Triazoles - administration & dosage Triazoles - therapeutic use |
| title | Anti-Inflammatory Effect of Maraviroc in an HIV-Infected Patient With Concomitant Myositis: A Case Report |
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