Constitutive activation of mTOR signaling pathway in post-transplant lymphoproliferative disorders

We examined activation of the mTOR signaling pathway in situ in the primary, normal reactive and patient-derived post-transplant lymphoproliferative disorder (PTLD) tissue samples. We accomplished this analysis by immunohistochemistry on formalin-fixed, paraffin-embedded specimens using a set of hig...

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Veröffentlicht in:	Laboratory investigation 2007-01, Vol.87 (1), p.29-39
Hauptverfasser:	El-Salem, Mouna, Raghunath, Puthiyaveettil N, Marzec, Michal, Wlodarski, Pawel, Tsai, Donald, Hsi, Eric, Wasik, Mariusz A
Format:	Artikel
Sprache:	eng
Schlagworte:	4E-binding protein 1 Adaptor Proteins, Signal Transducing - metabolism Biological and medical sciences Biotechnology Cell Cycle Proteins Cell Line, Tumor Epstein-Barr virus eukaryotic initiation factor 4G Eukaryotic Initiation Factor-4G - metabolism Fundamental and applied biological sciences. Psychology Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Laboratory Medicine Lymphoproliferative Disorders - metabolism mammalian target of rapamycin Medical sciences Medicine Medicine & Public Health Organ Transplantation - adverse effects Pathology Phosphoproteins - metabolism post-transplant lymphoproliferative disorder Protein Kinases - metabolism rapamycin research-article Ribosomal Protein S6 - metabolism S6 ribosomal protein Signal Transduction - physiology Sirolimus - pharmacology TOR Serine-Threonine Kinases
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