Renal artery calcified plaque associations with subclinical renal and cardiovascular disease
Renal artery calcified plaque associations with subclinical renal and cardiovascular disease. The prognostic significance of renal artery calcified plaque (RAC) and its relationship with renal function, albuminuria, and systemic atherosclerosis are unknown. Calcified atherosclerotic plaque was measu...
Gespeichert in:
| Veröffentlicht in: | Kidney international 2004-06, Vol.65 (6), p.2262-2267 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2267 |
|---|---|
| container_issue | 6 |
| container_start_page | 2262 |
| container_title | Kidney international |
| container_volume | 65 |
| creator | Freedman, Barry I. Hsu, Fang-Chi Langefeld, Carl D. Bowden, Donald W. Moossavi, Shahriar Dryman, Bonnie N. Carr, J. Jeffrey |
| description | Renal artery calcified plaque associations with subclinical renal and cardiovascular disease.
The prognostic significance of renal artery calcified plaque (RAC) and its relationship with renal function, albuminuria, and systemic atherosclerosis are unknown.
Calcified atherosclerotic plaque was measured in the renal arteries of 96 unrelated Caucasian subjects with type 2 diabetes mellitus (DM) using four-channel multidetector–row computed tomography (MDCT4). Renal artery calcium was measured as the sum of ostial and main renal artery calcium scores. Participants also underwent MDCT scanning to measure coronary artery calcium (CAC), carotid artery calcium, common iliac artery calcium, infra-renal aorta calcium, and B-mode ultrasound to measure carotid artery intima-medial thickness (IMT). Spearman's rank correlation coefficients were used to assess associations between RAC and measures of subclinical renal and cardiovascular disease. Partial correlation coefficients were computed to adjust for the potential confounding effects of age, gender, body mass index (BMI), DM duration, smoking, and serum cholesterol and triglyceride levels.
Characteristics of the study group were 54% (52/96) female with a mean ± SD (median) age 62.8 ± 8.4 (62.5) years, DM duration 10.6 ± 6.3 (8.0) years, hemoglobin A1C 7.5 ± 1.5 (7.2)%, BMI 32.1 ± 6.3 (31.1) kg/m2, serum creatinine concentration 1.11 ± 0.18 (1.10) mg/dL, urine albumin:creatinine ratio (ACR) 105.3 ± 423.1 (17.6) mg/g, modified MDRD equation glomerular filtration rate (GFR) 64.3 ± 12.6 (63.6) mL/min, RAC 372 ± 799 (101), CAC 1819 ± 2594 (622), carotid artery calcium 264 ± 451 (72), and B-mode ultrasound carotid IMT 0.70 ± 0.12 (0.69) mm. Sixty-five percent of subjects (62/96) had detectable RAC. Renal artery calcium was significantly associated with CAC (r = 0.50, P < 0.0001), carotid artery calcium (r = 0.58, P < 0.0001), common iliac artery calcium (r = 0.45, P < 0.0001), infra-renal aorta calcium (r = 0.70, P < 0.0001), IMT (r = 0.40, P = 0.0004), diastolic blood pressure (r=-0.33, P = 0.0009), BMI (r=-0.19, P = 0.0573), and age (r = 0.54, P < 0.0001). There was no association between RAC and GFR (r=-0.15, P = 0.1637) or between RAC and urine ACR (r = 0.07, P = 0.5083).
Renal artery calcium is strongly associated with older age, diastolic blood pressure, BMI, carotid artery IMT, and coronary, carotid, common iliac artery, and infra-renal aorta calcium in Caucasians with type 2 diabetes mellitus. Renal artery calciu |
| doi_str_mv | 10.1111/j.1523-1755.2004.00645.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_755133184</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0085253815499715</els_id><sourcerecordid>71937897</sourcerecordid><originalsourceid>FETCH-LOGICAL-c509t-9d1ee43b1206635248d5d71fd66e7abd67db91c3d46802af21b4dfd453ad2ae63</originalsourceid><addsrcrecordid>eNqFkV2L1DAUhoMo7rj6F6QIuletOflo00tdXBUWBNE7IaTJKWbItGNOu-7-ezPOoOKF5iaEPG84eR_GKuANlPVy24AWsoZO60ZwrhrOW6Wb23ts8-viPttwbnQttDRn7BHRlpdzL_lDdgYaVC9lv2FfPuLkUuXygvmu8i75OEYM1T65bytWjmj20S1xnqj6HpevFa2DT3GKBa3yMTuFEswhzjeO_JpcrkIkdISP2YPRJcInp_2cfb568-nyXX394e37y1fXtde8X-o-AKKSAwjetlILZYIOHYyhbbFzQ2i7MPTgZVCt4cKNAgYVxqC0dEE4bOU5uzi-u89zmZoWu4vkMSU34bySLW2AlGBUIV_8m4RedqbvCvjsL3A7r7l8l6wADiB0ZwpkjpDPM1HG0e5z3Ll8Z4Hbgyi7tQcf9uDDHkTZn6LsbYk-Pb2_DjsMv4MnMwV4fgJKqS6N2U0-0h-cKU1xUbjXRw5LwTcRsyUfcfIYYka_2DDH_0_zA1SIsc0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>210112578</pqid></control><display><type>article</type><title>Renal artery calcified plaque associations with subclinical renal and cardiovascular disease</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>ProQuest Central UK/Ireland</source><source>Alma/SFX Local Collection</source><creator>Freedman, Barry I. ; Hsu, Fang-Chi ; Langefeld, Carl D. ; Bowden, Donald W. ; Moossavi, Shahriar ; Dryman, Bonnie N. ; Carr, J. Jeffrey</creator><creatorcontrib>Freedman, Barry I. ; Hsu, Fang-Chi ; Langefeld, Carl D. ; Bowden, Donald W. ; Moossavi, Shahriar ; Dryman, Bonnie N. ; Carr, J. Jeffrey</creatorcontrib><description>Renal artery calcified plaque associations with subclinical renal and cardiovascular disease.
The prognostic significance of renal artery calcified plaque (RAC) and its relationship with renal function, albuminuria, and systemic atherosclerosis are unknown.
Calcified atherosclerotic plaque was measured in the renal arteries of 96 unrelated Caucasian subjects with type 2 diabetes mellitus (DM) using four-channel multidetector–row computed tomography (MDCT4). Renal artery calcium was measured as the sum of ostial and main renal artery calcium scores. Participants also underwent MDCT scanning to measure coronary artery calcium (CAC), carotid artery calcium, common iliac artery calcium, infra-renal aorta calcium, and B-mode ultrasound to measure carotid artery intima-medial thickness (IMT). Spearman's rank correlation coefficients were used to assess associations between RAC and measures of subclinical renal and cardiovascular disease. Partial correlation coefficients were computed to adjust for the potential confounding effects of age, gender, body mass index (BMI), DM duration, smoking, and serum cholesterol and triglyceride levels.
Characteristics of the study group were 54% (52/96) female with a mean ± SD (median) age 62.8 ± 8.4 (62.5) years, DM duration 10.6 ± 6.3 (8.0) years, hemoglobin A1C 7.5 ± 1.5 (7.2)%, BMI 32.1 ± 6.3 (31.1) kg/m2, serum creatinine concentration 1.11 ± 0.18 (1.10) mg/dL, urine albumin:creatinine ratio (ACR) 105.3 ± 423.1 (17.6) mg/g, modified MDRD equation glomerular filtration rate (GFR) 64.3 ± 12.6 (63.6) mL/min, RAC 372 ± 799 (101), CAC 1819 ± 2594 (622), carotid artery calcium 264 ± 451 (72), and B-mode ultrasound carotid IMT 0.70 ± 0.12 (0.69) mm. Sixty-five percent of subjects (62/96) had detectable RAC. Renal artery calcium was significantly associated with CAC (r = 0.50, P < 0.0001), carotid artery calcium (r = 0.58, P < 0.0001), common iliac artery calcium (r = 0.45, P < 0.0001), infra-renal aorta calcium (r = 0.70, P < 0.0001), IMT (r = 0.40, P = 0.0004), diastolic blood pressure (r=-0.33, P = 0.0009), BMI (r=-0.19, P = 0.0573), and age (r = 0.54, P < 0.0001). There was no association between RAC and GFR (r=-0.15, P = 0.1637) or between RAC and urine ACR (r = 0.07, P = 0.5083).
Renal artery calcium is strongly associated with older age, diastolic blood pressure, BMI, carotid artery IMT, and coronary, carotid, common iliac artery, and infra-renal aorta calcium in Caucasians with type 2 diabetes mellitus. Renal artery calcium, similar to CAC and IMT, appears to be a useful noninvasive marker of subclinical atherosclerosis. However, RAC is not significantly associated with either GFR or albuminuria.</description><identifier>ISSN: 0085-2538</identifier><identifier>EISSN: 1523-1755</identifier><identifier>DOI: 10.1111/j.1523-1755.2004.00645.x</identifier><identifier>PMID: 15149339</identifier><identifier>CODEN: KDYIA5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; albuminuria ; Arteriosclerosis - complications ; Arteriosclerosis - diagnostic imaging ; Arteriosclerosis - pathology ; Biological and medical sciences ; Calcinosis - diagnostic imaging ; Calcinosis - pathology ; Cardiovascular Diseases - complications ; carotid artery intimal medial thickness ; computed tomography ; coronary artery calcium ; diabetes mellitus ; Diabetes Mellitus, Type 2 - complications ; Female ; glomerular filtration rate ; Humans ; Kidney Diseases - complications ; Male ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Renal Artery - diagnostic imaging ; Renal Artery - pathology ; renal artery calcium ; Tomography, X-Ray Computed</subject><ispartof>Kidney international, 2004-06, Vol.65 (6), p.2262-2267</ispartof><rights>2004 International Society of Nephrology</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Jun 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-9d1ee43b1206635248d5d71fd66e7abd67db91c3d46802af21b4dfd453ad2ae63</citedby><cites>FETCH-LOGICAL-c509t-9d1ee43b1206635248d5d71fd66e7abd67db91c3d46802af21b4dfd453ad2ae63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/210112578?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15835202$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15149339$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Freedman, Barry I.</creatorcontrib><creatorcontrib>Hsu, Fang-Chi</creatorcontrib><creatorcontrib>Langefeld, Carl D.</creatorcontrib><creatorcontrib>Bowden, Donald W.</creatorcontrib><creatorcontrib>Moossavi, Shahriar</creatorcontrib><creatorcontrib>Dryman, Bonnie N.</creatorcontrib><creatorcontrib>Carr, J. Jeffrey</creatorcontrib><title>Renal artery calcified plaque associations with subclinical renal and cardiovascular disease</title><title>Kidney international</title><addtitle>Kidney Int</addtitle><description>Renal artery calcified plaque associations with subclinical renal and cardiovascular disease.
The prognostic significance of renal artery calcified plaque (RAC) and its relationship with renal function, albuminuria, and systemic atherosclerosis are unknown.
Calcified atherosclerotic plaque was measured in the renal arteries of 96 unrelated Caucasian subjects with type 2 diabetes mellitus (DM) using four-channel multidetector–row computed tomography (MDCT4). Renal artery calcium was measured as the sum of ostial and main renal artery calcium scores. Participants also underwent MDCT scanning to measure coronary artery calcium (CAC), carotid artery calcium, common iliac artery calcium, infra-renal aorta calcium, and B-mode ultrasound to measure carotid artery intima-medial thickness (IMT). Spearman's rank correlation coefficients were used to assess associations between RAC and measures of subclinical renal and cardiovascular disease. Partial correlation coefficients were computed to adjust for the potential confounding effects of age, gender, body mass index (BMI), DM duration, smoking, and serum cholesterol and triglyceride levels.
Characteristics of the study group were 54% (52/96) female with a mean ± SD (median) age 62.8 ± 8.4 (62.5) years, DM duration 10.6 ± 6.3 (8.0) years, hemoglobin A1C 7.5 ± 1.5 (7.2)%, BMI 32.1 ± 6.3 (31.1) kg/m2, serum creatinine concentration 1.11 ± 0.18 (1.10) mg/dL, urine albumin:creatinine ratio (ACR) 105.3 ± 423.1 (17.6) mg/g, modified MDRD equation glomerular filtration rate (GFR) 64.3 ± 12.6 (63.6) mL/min, RAC 372 ± 799 (101), CAC 1819 ± 2594 (622), carotid artery calcium 264 ± 451 (72), and B-mode ultrasound carotid IMT 0.70 ± 0.12 (0.69) mm. Sixty-five percent of subjects (62/96) had detectable RAC. Renal artery calcium was significantly associated with CAC (r = 0.50, P < 0.0001), carotid artery calcium (r = 0.58, P < 0.0001), common iliac artery calcium (r = 0.45, P < 0.0001), infra-renal aorta calcium (r = 0.70, P < 0.0001), IMT (r = 0.40, P = 0.0004), diastolic blood pressure (r=-0.33, P = 0.0009), BMI (r=-0.19, P = 0.0573), and age (r = 0.54, P < 0.0001). There was no association between RAC and GFR (r=-0.15, P = 0.1637) or between RAC and urine ACR (r = 0.07, P = 0.5083).
Renal artery calcium is strongly associated with older age, diastolic blood pressure, BMI, carotid artery IMT, and coronary, carotid, common iliac artery, and infra-renal aorta calcium in Caucasians with type 2 diabetes mellitus. Renal artery calcium, similar to CAC and IMT, appears to be a useful noninvasive marker of subclinical atherosclerosis. However, RAC is not significantly associated with either GFR or albuminuria.</description><subject>Adult</subject><subject>Aged</subject><subject>albuminuria</subject><subject>Arteriosclerosis - complications</subject><subject>Arteriosclerosis - diagnostic imaging</subject><subject>Arteriosclerosis - pathology</subject><subject>Biological and medical sciences</subject><subject>Calcinosis - diagnostic imaging</subject><subject>Calcinosis - pathology</subject><subject>Cardiovascular Diseases - complications</subject><subject>carotid artery intimal medial thickness</subject><subject>computed tomography</subject><subject>coronary artery calcium</subject><subject>diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Female</subject><subject>glomerular filtration rate</subject><subject>Humans</subject><subject>Kidney Diseases - complications</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Renal Artery - diagnostic imaging</subject><subject>Renal Artery - pathology</subject><subject>renal artery calcium</subject><subject>Tomography, X-Ray Computed</subject><issn>0085-2538</issn><issn>1523-1755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkV2L1DAUhoMo7rj6F6QIuletOflo00tdXBUWBNE7IaTJKWbItGNOu-7-ezPOoOKF5iaEPG84eR_GKuANlPVy24AWsoZO60ZwrhrOW6Wb23ts8-viPttwbnQttDRn7BHRlpdzL_lDdgYaVC9lv2FfPuLkUuXygvmu8i75OEYM1T65bytWjmj20S1xnqj6HpevFa2DT3GKBa3yMTuFEswhzjeO_JpcrkIkdISP2YPRJcInp_2cfb568-nyXX394e37y1fXtde8X-o-AKKSAwjetlILZYIOHYyhbbFzQ2i7MPTgZVCt4cKNAgYVxqC0dEE4bOU5uzi-u89zmZoWu4vkMSU34bySLW2AlGBUIV_8m4RedqbvCvjsL3A7r7l8l6wADiB0ZwpkjpDPM1HG0e5z3Ll8Z4Hbgyi7tQcf9uDDHkTZn6LsbYk-Pb2_DjsMv4MnMwV4fgJKqS6N2U0-0h-cKU1xUbjXRw5LwTcRsyUfcfIYYka_2DDH_0_zA1SIsc0</recordid><startdate>20040601</startdate><enddate>20040601</enddate><creator>Freedman, Barry I.</creator><creator>Hsu, Fang-Chi</creator><creator>Langefeld, Carl D.</creator><creator>Bowden, Donald W.</creator><creator>Moossavi, Shahriar</creator><creator>Dryman, Bonnie N.</creator><creator>Carr, J. Jeffrey</creator><general>Elsevier Inc</general><general>Nature Publishing</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QR</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20040601</creationdate><title>Renal artery calcified plaque associations with subclinical renal and cardiovascular disease</title><author>Freedman, Barry I. ; Hsu, Fang-Chi ; Langefeld, Carl D. ; Bowden, Donald W. ; Moossavi, Shahriar ; Dryman, Bonnie N. ; Carr, J. Jeffrey</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-9d1ee43b1206635248d5d71fd66e7abd67db91c3d46802af21b4dfd453ad2ae63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>albuminuria</topic><topic>Arteriosclerosis - complications</topic><topic>Arteriosclerosis - diagnostic imaging</topic><topic>Arteriosclerosis - pathology</topic><topic>Biological and medical sciences</topic><topic>Calcinosis - diagnostic imaging</topic><topic>Calcinosis - pathology</topic><topic>Cardiovascular Diseases - complications</topic><topic>carotid artery intimal medial thickness</topic><topic>computed tomography</topic><topic>coronary artery calcium</topic><topic>diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Female</topic><topic>glomerular filtration rate</topic><topic>Humans</topic><topic>Kidney Diseases - complications</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Renal Artery - diagnostic imaging</topic><topic>Renal Artery - pathology</topic><topic>renal artery calcium</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Freedman, Barry I.</creatorcontrib><creatorcontrib>Hsu, Fang-Chi</creatorcontrib><creatorcontrib>Langefeld, Carl D.</creatorcontrib><creatorcontrib>Bowden, Donald W.</creatorcontrib><creatorcontrib>Moossavi, Shahriar</creatorcontrib><creatorcontrib>Dryman, Bonnie N.</creatorcontrib><creatorcontrib>Carr, J. Jeffrey</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Chemoreception Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Kidney international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Freedman, Barry I.</au><au>Hsu, Fang-Chi</au><au>Langefeld, Carl D.</au><au>Bowden, Donald W.</au><au>Moossavi, Shahriar</au><au>Dryman, Bonnie N.</au><au>Carr, J. Jeffrey</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Renal artery calcified plaque associations with subclinical renal and cardiovascular disease</atitle><jtitle>Kidney international</jtitle><addtitle>Kidney Int</addtitle><date>2004-06-01</date><risdate>2004</risdate><volume>65</volume><issue>6</issue><spage>2262</spage><epage>2267</epage><pages>2262-2267</pages><issn>0085-2538</issn><eissn>1523-1755</eissn><coden>KDYIA5</coden><abstract>Renal artery calcified plaque associations with subclinical renal and cardiovascular disease.
The prognostic significance of renal artery calcified plaque (RAC) and its relationship with renal function, albuminuria, and systemic atherosclerosis are unknown.
Calcified atherosclerotic plaque was measured in the renal arteries of 96 unrelated Caucasian subjects with type 2 diabetes mellitus (DM) using four-channel multidetector–row computed tomography (MDCT4). Renal artery calcium was measured as the sum of ostial and main renal artery calcium scores. Participants also underwent MDCT scanning to measure coronary artery calcium (CAC), carotid artery calcium, common iliac artery calcium, infra-renal aorta calcium, and B-mode ultrasound to measure carotid artery intima-medial thickness (IMT). Spearman's rank correlation coefficients were used to assess associations between RAC and measures of subclinical renal and cardiovascular disease. Partial correlation coefficients were computed to adjust for the potential confounding effects of age, gender, body mass index (BMI), DM duration, smoking, and serum cholesterol and triglyceride levels.
Characteristics of the study group were 54% (52/96) female with a mean ± SD (median) age 62.8 ± 8.4 (62.5) years, DM duration 10.6 ± 6.3 (8.0) years, hemoglobin A1C 7.5 ± 1.5 (7.2)%, BMI 32.1 ± 6.3 (31.1) kg/m2, serum creatinine concentration 1.11 ± 0.18 (1.10) mg/dL, urine albumin:creatinine ratio (ACR) 105.3 ± 423.1 (17.6) mg/g, modified MDRD equation glomerular filtration rate (GFR) 64.3 ± 12.6 (63.6) mL/min, RAC 372 ± 799 (101), CAC 1819 ± 2594 (622), carotid artery calcium 264 ± 451 (72), and B-mode ultrasound carotid IMT 0.70 ± 0.12 (0.69) mm. Sixty-five percent of subjects (62/96) had detectable RAC. Renal artery calcium was significantly associated with CAC (r = 0.50, P < 0.0001), carotid artery calcium (r = 0.58, P < 0.0001), common iliac artery calcium (r = 0.45, P < 0.0001), infra-renal aorta calcium (r = 0.70, P < 0.0001), IMT (r = 0.40, P = 0.0004), diastolic blood pressure (r=-0.33, P = 0.0009), BMI (r=-0.19, P = 0.0573), and age (r = 0.54, P < 0.0001). There was no association between RAC and GFR (r=-0.15, P = 0.1637) or between RAC and urine ACR (r = 0.07, P = 0.5083).
Renal artery calcium is strongly associated with older age, diastolic blood pressure, BMI, carotid artery IMT, and coronary, carotid, common iliac artery, and infra-renal aorta calcium in Caucasians with type 2 diabetes mellitus. Renal artery calcium, similar to CAC and IMT, appears to be a useful noninvasive marker of subclinical atherosclerosis. However, RAC is not significantly associated with either GFR or albuminuria.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15149339</pmid><doi>10.1111/j.1523-1755.2004.00645.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0085-2538 |
| ispartof | Kidney international, 2004-06, Vol.65 (6), p.2262-2267 |
| issn | 0085-2538 1523-1755 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_755133184 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; Alma/SFX Local Collection |
| subjects | Adult Aged albuminuria Arteriosclerosis - complications Arteriosclerosis - diagnostic imaging Arteriosclerosis - pathology Biological and medical sciences Calcinosis - diagnostic imaging Calcinosis - pathology Cardiovascular Diseases - complications carotid artery intimal medial thickness computed tomography coronary artery calcium diabetes mellitus Diabetes Mellitus, Type 2 - complications Female glomerular filtration rate Humans Kidney Diseases - complications Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Renal Artery - diagnostic imaging Renal Artery - pathology renal artery calcium Tomography, X-Ray Computed |
| title | Renal artery calcified plaque associations with subclinical renal and cardiovascular disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T22%3A06%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Renal%20artery%20calcified%20plaque%20associations%20with%20subclinical%20renal%20and%20cardiovascular%20disease&rft.jtitle=Kidney%20international&rft.au=Freedman,%20Barry%20I.&rft.date=2004-06-01&rft.volume=65&rft.issue=6&rft.spage=2262&rft.epage=2267&rft.pages=2262-2267&rft.issn=0085-2538&rft.eissn=1523-1755&rft.coden=KDYIA5&rft_id=info:doi/10.1111/j.1523-1755.2004.00645.x&rft_dat=%3Cproquest_cross%3E71937897%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=210112578&rft_id=info:pmid/15149339&rft_els_id=S0085253815499715&rfr_iscdi=true |