The Urokinase Plasminogen Activator Receptor–Associated Protein/Endo180 Is Coexpressed with Its Interaction Partners Urokinase Plasminogen Activator Receptor and Matrix Metalloprotease-13 during Osteogenesis
The urokinase plasminogen activator receptor–associated protein/Endo180 (uPARAP/Endo180) is a newly discovered member of the macrophage mannose receptor family that was reported to interact with ligand-bound urokinase plasminogen activator receptor (uPAR), matrix metalloprotease-13 (MMP-13), and col...
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| Veröffentlicht in: | Laboratory investigation 2001-10, Vol.81 (10), p.1403-1414 |
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| creator | Engelholm, Lars Henning Nielsen, Boye Schnack Netzel-Arnett, Sarah Solberg, Helene Chen, Xiao-Dong Lopez Garcia, Jose Manuel Lopez-Otin, Carlos Young, Marian Francis Birkedal-Hansen, Henning Danø, Keld Lund, Leif Røge Behrendt, Niels Bugge, Thomas Henrik |
| description | The urokinase plasminogen activator receptor–associated protein/Endo180 (uPARAP/Endo180) is a newly discovered member of the macrophage mannose receptor family that was reported to interact with ligand-bound urokinase plasminogen activator receptor (uPAR), matrix metalloprotease-13 (MMP-13), and collagen V on the cell surface. We have determined the sites of expression of this novel receptor during murine postimplantation development. uPARAP/Endo180 was expressed in all tissues undergoing primary ossification, including the developing bones of the viscerocranium and calvarium that ossify intramembranously, and developing long bones undergoing endochondral ossification. uPARAP/Endo180 mRNA was expressed by both immature osteoblasts and by mature osteocalcin-producing osteoblasts-osteocytes, and was coexpressed with MMP-13. Interestingly, osteoblasts also expressed uPAR. Besides bone-forming tissues, uPARAP/Endo180 expression was detected only in a mesenchymal condensation of the midbrain and in the developing lungs. The data suggest a function of this novel protease receptor in bone development, possibly mediated through its interactions with uPAR, MMP-13, or collagen V. |
| doi_str_mv | 10.1038/labinvest.3780354 |
| format | Article |
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We have determined the sites of expression of this novel receptor during murine postimplantation development. uPARAP/Endo180 was expressed in all tissues undergoing primary ossification, including the developing bones of the viscerocranium and calvarium that ossify intramembranously, and developing long bones undergoing endochondral ossification. uPARAP/Endo180 mRNA was expressed by both immature osteoblasts and by mature osteocalcin-producing osteoblasts-osteocytes, and was coexpressed with MMP-13. Interestingly, osteoblasts also expressed uPAR. Besides bone-forming tissues, uPARAP/Endo180 expression was detected only in a mesenchymal condensation of the midbrain and in the developing lungs. The data suggest a function of this novel protease receptor in bone development, possibly mediated through its interactions with uPAR, MMP-13, or collagen V.</description><identifier>ISSN: 0023-6837</identifier><identifier>EISSN: 1530-0307</identifier><identifier>DOI: 10.1038/labinvest.3780354</identifier><identifier>PMID: 11598153</identifier><identifier>CODEN: LAINAW</identifier><language>eng</language><publisher>New York: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Bone and Bones - embryology ; Bone and Bones - physiology ; Collagenases - biosynthesis ; Embryonic and Fetal Development ; Female ; Fundamental and applied biological sciences. Psychology ; Immunohistochemistry ; Laboratory Medicine ; Matrix Metalloproteinase 13 ; Medicine ; Medicine & Public Health ; Mice ; Osteogenesis - physiology ; Pathology ; Pregnancy ; Receptors, Cell Surface - biosynthesis ; Receptors, Mitogen - biosynthesis ; Receptors, Urokinase Plasminogen Activator ; Skeleton and joints ; Vertebrates: osteoarticular system, musculoskeletal system</subject><ispartof>Laboratory investigation, 2001-10, Vol.81 (10), p.1403-1414</ispartof><rights>2001 United States & Canadian Academy of Pathology</rights><rights>The United States and Canadian Academy of Pathology, Inc. 2001</rights><rights>2002 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Oct 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c546t-1050e23757d46e0c3ee7602a5a95062ed6d70387f3e69d19c5a1d90be55f25553</citedby><cites>FETCH-LOGICAL-c546t-1050e23757d46e0c3ee7602a5a95062ed6d70387f3e69d19c5a1d90be55f25553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14151666$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11598153$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Engelholm, Lars Henning</creatorcontrib><creatorcontrib>Nielsen, Boye Schnack</creatorcontrib><creatorcontrib>Netzel-Arnett, Sarah</creatorcontrib><creatorcontrib>Solberg, Helene</creatorcontrib><creatorcontrib>Chen, Xiao-Dong</creatorcontrib><creatorcontrib>Lopez Garcia, Jose Manuel</creatorcontrib><creatorcontrib>Lopez-Otin, Carlos</creatorcontrib><creatorcontrib>Young, Marian Francis</creatorcontrib><creatorcontrib>Birkedal-Hansen, Henning</creatorcontrib><creatorcontrib>Danø, Keld</creatorcontrib><creatorcontrib>Lund, Leif Røge</creatorcontrib><creatorcontrib>Behrendt, Niels</creatorcontrib><creatorcontrib>Bugge, Thomas Henrik</creatorcontrib><title>The Urokinase Plasminogen Activator Receptor–Associated Protein/Endo180 Is Coexpressed with Its Interaction Partners Urokinase Plasminogen Activator Receptor and Matrix Metalloprotease-13 during Osteogenesis</title><title>Laboratory investigation</title><addtitle>Lab Invest</addtitle><addtitle>Lab Invest</addtitle><description>The urokinase plasminogen activator receptor–associated protein/Endo180 (uPARAP/Endo180) is a newly discovered member of the macrophage mannose receptor family that was reported to interact with ligand-bound urokinase plasminogen activator receptor (uPAR), matrix metalloprotease-13 (MMP-13), and collagen V on the cell surface. We have determined the sites of expression of this novel receptor during murine postimplantation development. uPARAP/Endo180 was expressed in all tissues undergoing primary ossification, including the developing bones of the viscerocranium and calvarium that ossify intramembranously, and developing long bones undergoing endochondral ossification. uPARAP/Endo180 mRNA was expressed by both immature osteoblasts and by mature osteocalcin-producing osteoblasts-osteocytes, and was coexpressed with MMP-13. Interestingly, osteoblasts also expressed uPAR. Besides bone-forming tissues, uPARAP/Endo180 expression was detected only in a mesenchymal condensation of the midbrain and in the developing lungs. The data suggest a function of this novel protease receptor in bone development, possibly mediated through its interactions with uPAR, MMP-13, or collagen V.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bone and Bones - embryology</subject><subject>Bone and Bones - physiology</subject><subject>Collagenases - biosynthesis</subject><subject>Embryonic and Fetal Development</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immunohistochemistry</subject><subject>Laboratory Medicine</subject><subject>Matrix Metalloproteinase 13</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mice</subject><subject>Osteogenesis - physiology</subject><subject>Pathology</subject><subject>Pregnancy</subject><subject>Receptors, Cell Surface - biosynthesis</subject><subject>Receptors, Mitogen - biosynthesis</subject><subject>Receptors, Urokinase Plasminogen Activator</subject><subject>Skeleton and joints</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><issn>0023-6837</issn><issn>1530-0307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNksFuEzEQhlcIREPhATiALCTgtK29Xnuz4hRFBSK1aoTa88qxZ1uXjb14vKHceAeejFfgSfAqUSNxiDjZ0nz_P2PPn2UvGT1hlE9PO7WybgMYT3g1pVyUj7IJE5zmlNPqcTahtOC5nPLqKHuGeEcpK0spnmZHjIl6mshJ9vvqFsh18F-tUwhk2SlcW-dvwJGZjnajog_kC2jo0-XPz18zRK-timDIMvgI1p2eOePZlJIFkrmH-z4AYip_t_GWLCKShYsQVDLzjixViA4C_ndLopwhFyoGe08uIKqu8_3YNylzxokZgnU35BIjjAaAFp9nT1rVIbzYncfZ9cezq_nn_Pzy02I-O8-1KGXMGRUUCl6JypQSqOYAlaSFEqoWVBZgpKnSH1ctB1kbVmuhmKnpCoRoCyEEP87eb33TPN-GtIRmbVFD1ykHfsCmEoJxTkWZyHeHyYLVZc2qBL75B7zzQ3DpFU1RpJ2WJR_d2BbSwSMGaJs-2LUKPxpGmzEWzUMsml0skub1znhYrcHsFbscJODtDlCoVdcG5bTFPVcywaSUiSu2HPbjx0PYT3io-6utyKk4BHhw3dc_bOuQ1rWxyRS1BafB2AA6NsbbA-5_AVY09sE</recordid><startdate>20011001</startdate><enddate>20011001</enddate><creator>Engelholm, Lars Henning</creator><creator>Nielsen, Boye Schnack</creator><creator>Netzel-Arnett, Sarah</creator><creator>Solberg, Helene</creator><creator>Chen, Xiao-Dong</creator><creator>Lopez Garcia, Jose Manuel</creator><creator>Lopez-Otin, Carlos</creator><creator>Young, Marian Francis</creator><creator>Birkedal-Hansen, Henning</creator><creator>Danø, Keld</creator><creator>Lund, Leif Røge</creator><creator>Behrendt, Niels</creator><creator>Bugge, Thomas Henrik</creator><general>Elsevier Inc</general><general>Nature Publishing Group US</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20011001</creationdate><title>The Urokinase Plasminogen Activator Receptor–Associated Protein/Endo180 Is Coexpressed with Its Interaction Partners Urokinase Plasminogen Activator Receptor and Matrix Metalloprotease-13 during Osteogenesis</title><author>Engelholm, Lars Henning ; Nielsen, Boye Schnack ; Netzel-Arnett, Sarah ; Solberg, Helene ; Chen, Xiao-Dong ; Lopez Garcia, Jose Manuel ; Lopez-Otin, Carlos ; Young, Marian Francis ; Birkedal-Hansen, Henning ; Danø, Keld ; Lund, Leif Røge ; Behrendt, Niels ; Bugge, Thomas Henrik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c546t-1050e23757d46e0c3ee7602a5a95062ed6d70387f3e69d19c5a1d90be55f25553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bone and Bones - embryology</topic><topic>Bone and Bones - physiology</topic><topic>Collagenases - biosynthesis</topic><topic>Embryonic and Fetal Development</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. 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We have determined the sites of expression of this novel receptor during murine postimplantation development. uPARAP/Endo180 was expressed in all tissues undergoing primary ossification, including the developing bones of the viscerocranium and calvarium that ossify intramembranously, and developing long bones undergoing endochondral ossification. uPARAP/Endo180 mRNA was expressed by both immature osteoblasts and by mature osteocalcin-producing osteoblasts-osteocytes, and was coexpressed with MMP-13. Interestingly, osteoblasts also expressed uPAR. Besides bone-forming tissues, uPARAP/Endo180 expression was detected only in a mesenchymal condensation of the midbrain and in the developing lungs. The data suggest a function of this novel protease receptor in bone development, possibly mediated through its interactions with uPAR, MMP-13, or collagen V.</abstract><cop>New York</cop><pub>Elsevier Inc</pub><pmid>11598153</pmid><doi>10.1038/labinvest.3780354</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Bone and Bones - embryology Bone and Bones - physiology Collagenases - biosynthesis Embryonic and Fetal Development Female Fundamental and applied biological sciences. Psychology Immunohistochemistry Laboratory Medicine Matrix Metalloproteinase 13 Medicine Medicine & Public Health Mice Osteogenesis - physiology Pathology Pregnancy Receptors, Cell Surface - biosynthesis Receptors, Mitogen - biosynthesis Receptors, Urokinase Plasminogen Activator Skeleton and joints Vertebrates: osteoarticular system, musculoskeletal system |
| title | The Urokinase Plasminogen Activator Receptor–Associated Protein/Endo180 Is Coexpressed with Its Interaction Partners Urokinase Plasminogen Activator Receptor and Matrix Metalloprotease-13 during Osteogenesis |
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