Time- and Dose-based Gene Expression Profiles Produced by a Bile-duct–damaging Chemical, 4,4′-methylene Dianiline, in Mouse Liver in an Acute Phase

A toxicogenomics study was performed in the mouse liver after treatment of a bile-duct–damaging chemical, 4,4′-methylene dianiline (MDA), across multiple doses and sampling times in an acute phase using the AB Expression Array System. Imprinting control region (ICR) mice were given a single oral adm...

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Veröffentlicht in:	Toxicologic pathology 2008-07, Vol.36 (5), p.660-673
Hauptverfasser:	Kwon, Sun-Bom, Park, Joon-Suk, Yi, Jung-Yeon, Hwang, Jae-Wong, Kim, Mingoo, Lee, Mi-Ock, Lee, Byung-Hoon, Kim, Hyung-Lae, Kim, Ju Han, Chung, Heekyoung, Kong, Gu, Kang, Kyung-Sun, Yoon, Byung-IL
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute-Phase Reaction - etiology Alanine Transaminase - blood Aniline Compounds - toxicity Animals Apoptosis - genetics Aspartate Aminotransferases - blood Bile Ducts - drug effects Bile Ducts - metabolism Bile Ducts - pathology Bilirubin - metabolism Biological and medical sciences Carcinogens - toxicity Cell Cycle - genetics Cell Cycle - physiology Dose-Response Relationship, Drug Gene Expression Profiling Genes, cdc Liver - drug effects Liver - metabolism Liver - pathology Liver Function Tests Medical sciences Mice Mice, Inbred ICR Models, Biological Oxidative Stress - genetics Random Allocation RNA, Messenger - analysis Specific Pathogen-Free Organisms Th1 Cells - metabolism Time Factors Toxicogenetics - methods Toxicology
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