Mild hypothermia via selective head cooling as neuroprotective therapy in term neonates with perinatal asphyxia: an experience from a single neonatal intensive care unit
Objective: The objective of this study was to determine the efficacy of mild hypothermia via selective head cooling as a neuroprotective therapy in term infants with perinatal asphyxia. Study design: Full-term newborns who had 5 min Apgar scores
Gespeichert in:
| Veröffentlicht in: | Journal of Perinatology 2006-03, Vol.26 (3), p.180-184 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 184 |
|---|---|
| container_issue | 3 |
| container_start_page | 180 |
| container_title | Journal of Perinatology |
| container_volume | 26 |
| creator | Lin, Z-L Yu, H-M Lin, J Chen, S-Q Liang, Z-Q Zhang, Z-Y |
| description | Objective:
The objective of this study was to determine the efficacy of mild hypothermia via selective head cooling as a neuroprotective therapy in term infants with perinatal asphyxia.
Study design:
Full-term newborns who had 5 min Apgar scores |
| doi_str_mv | 10.1038/sj.jp.7211412 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_755131741</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A183337278</galeid><sourcerecordid>A183337278</sourcerecordid><originalsourceid>FETCH-LOGICAL-c537t-e0e407b3697e88ab426475ef00135292c5b9ce1e1c3c39b61ed2254bd121b93b3</originalsourceid><addsrcrecordid>eNp9kk9v1DAQxSMEotvCkSPIolI5ZbHjJE64VRX_pCIucI4cZ7JxlNjBdkr3I_EtmWgDSxFFURQ57_fezMgTRc8Y3TLKi9e-3_bTViSMpSx5EG1YKvI4y1L-MNpQkfK44Gl-Ep1631O6iOJxdMLylIoyF5voxyc9NKTbTzZ04EYtyQ2-HgZQQd8A6UA2RFk7aLMj0hMDs7OTs2HVF5ec9kQbEtCPujUygCffdejIBE7jUQ5onbr9rZZviDQEbhcBjALSOjsSLIjxA6xuxLUJYPxSQEkHZDY6PIketXLw8HT9nkVf3739cvUhvv78_uPV5XWsMi5CDBRwtprnpYCikHWa5KnIoMXheZaUicrqUgEDprjiZZ0zaJIkS-uGJawuec3PoleHXJzy2ww-VKP2CoZBYnezr0SWMc5EypC8-C-Zi7woi5IieP4X2NvZGZyiwu5oVuYJK5B6eS-VULxdQctj1E4OUGnT2uCkWupWl5jBuUjEErX9B4VPA6NW1kCr8f8dw8UfBrz0IXTeDnPQ1vi7YHwAlbPeO2iryelRun3FaLUsZOX7qp-qdSGRf7EONdcjNEd63cBjqx4lswN3nPq-xOcHA27K7OB34i_9J5Jw9RI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>220412709</pqid></control><display><type>article</type><title>Mild hypothermia via selective head cooling as neuroprotective therapy in term neonates with perinatal asphyxia: an experience from a single neonatal intensive care unit</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><source>SpringerLink Journals - AutoHoldings</source><creator>Lin, Z-L ; Yu, H-M ; Lin, J ; Chen, S-Q ; Liang, Z-Q ; Zhang, Z-Y</creator><creatorcontrib>Lin, Z-L ; Yu, H-M ; Lin, J ; Chen, S-Q ; Liang, Z-Q ; Zhang, Z-Y</creatorcontrib><description>Objective:
The objective of this study was to determine the efficacy of mild hypothermia via selective head cooling as a neuroprotective therapy in term infants with perinatal asphyxia.
Study design:
Full-term newborns who had 5 min Apgar scores <6, first arterial blood gas pH<7.10 or BD>15 mEq/l, and with the clinical signs of encephalopathy were enrolled within 6 h after birth. Patients were randomized to receive mild hypothermia treatment via selective head cooling for a total of 72 h or receive routine treatment as a control. Brain hypoxic-ischemic injury was quantified based on the head computed tomographic scan (CT scan) at postnatal age 5–7 days and a Neonatal Behavioral Neurological Assessment (NBNA) score at 7–10 days of life.
Results:
A total of 58 patients (30 hypothermia, 28 control) completed the study. Hypothermia was well tolerated in this study and attenuated the hypoxic-ischemic brain injury due to perinatal asphyxia. Head CT scan demonstrated moderate to severe hypoxic-ischemic changes in only 4/30 cases from the hypothermic group. In contrast, 18/28 cases in the control group showed moderate to severe hypoxic-ischemic changes (
χ
2
=15.97,
P
<0.01). Brain hypothermia also significantly improved the NBNA score (32±2 in the hypothermic group vs 28±3 in the control group,
P
<0.01).
Conclusion
s: Our results suggest that selective head cooling may be used as a neuroprotective therapy in term neonates with perinatal asphyxia. A long-term follow-up study is needed to further validate the results of this study.</description><identifier>ISSN: 0743-8346</identifier><identifier>EISSN: 1476-5543</identifier><identifier>DOI: 10.1038/sj.jp.7211412</identifier><identifier>PMID: 16407967</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Apgar Score ; Asphyxia ; Asphyxia neonatorum ; Asphyxia Neonatorum - diagnosis ; Asphyxia Neonatorum - therapy ; Brain ; Brain damage ; Brain injury ; Care and treatment ; Case-Control Studies ; Complications and side effects ; Computed tomography ; Control ; Cooling ; Diagnosis ; Encephalopathy ; Female ; Follow-Up Studies ; Gestational Age ; Head ; Head injuries ; Humans ; Hypothermia ; Hypothermia, Induced - methods ; Hypoxia ; Hypoxia, Brain - prevention & control ; Infant, Newborn ; Intensive Care Units, Neonatal ; Ischemia ; Male ; Medical imaging ; Medicine ; Medicine & Public Health ; Neonates ; Neuroprotection ; Newborn babies ; original-article ; Patients ; Pediatric Surgery ; Pediatrics ; Pregnancy ; Prognosis ; Reference Values ; Risk Assessment ; Risk factors ; Sensitivity and Specificity ; Severity of Illness Index ; Suffocation ; Survival Rate ; Therapy ; Treatment Outcome</subject><ispartof>Journal of Perinatology, 2006-03, Vol.26 (3), p.180-184</ispartof><rights>Springer Nature America, Inc. 2006</rights><rights>COPYRIGHT 2006 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Mar 2006</rights><rights>Nature Publishing Group 2006.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-e0e407b3697e88ab426475ef00135292c5b9ce1e1c3c39b61ed2254bd121b93b3</citedby><cites>FETCH-LOGICAL-c537t-e0e407b3697e88ab426475ef00135292c5b9ce1e1c3c39b61ed2254bd121b93b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.jp.7211412$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.jp.7211412$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16407967$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Z-L</creatorcontrib><creatorcontrib>Yu, H-M</creatorcontrib><creatorcontrib>Lin, J</creatorcontrib><creatorcontrib>Chen, S-Q</creatorcontrib><creatorcontrib>Liang, Z-Q</creatorcontrib><creatorcontrib>Zhang, Z-Y</creatorcontrib><title>Mild hypothermia via selective head cooling as neuroprotective therapy in term neonates with perinatal asphyxia: an experience from a single neonatal intensive care unit</title><title>Journal of Perinatology</title><addtitle>J Perinatol</addtitle><addtitle>J Perinatol</addtitle><description>Objective:
The objective of this study was to determine the efficacy of mild hypothermia via selective head cooling as a neuroprotective therapy in term infants with perinatal asphyxia.
Study design:
Full-term newborns who had 5 min Apgar scores <6, first arterial blood gas pH<7.10 or BD>15 mEq/l, and with the clinical signs of encephalopathy were enrolled within 6 h after birth. Patients were randomized to receive mild hypothermia treatment via selective head cooling for a total of 72 h or receive routine treatment as a control. Brain hypoxic-ischemic injury was quantified based on the head computed tomographic scan (CT scan) at postnatal age 5–7 days and a Neonatal Behavioral Neurological Assessment (NBNA) score at 7–10 days of life.
Results:
A total of 58 patients (30 hypothermia, 28 control) completed the study. Hypothermia was well tolerated in this study and attenuated the hypoxic-ischemic brain injury due to perinatal asphyxia. Head CT scan demonstrated moderate to severe hypoxic-ischemic changes in only 4/30 cases from the hypothermic group. In contrast, 18/28 cases in the control group showed moderate to severe hypoxic-ischemic changes (
χ
2
=15.97,
P
<0.01). Brain hypothermia also significantly improved the NBNA score (32±2 in the hypothermic group vs 28±3 in the control group,
P
<0.01).
Conclusion
s: Our results suggest that selective head cooling may be used as a neuroprotective therapy in term neonates with perinatal asphyxia. A long-term follow-up study is needed to further validate the results of this study.</description><subject>Apgar Score</subject><subject>Asphyxia</subject><subject>Asphyxia neonatorum</subject><subject>Asphyxia Neonatorum - diagnosis</subject><subject>Asphyxia Neonatorum - therapy</subject><subject>Brain</subject><subject>Brain damage</subject><subject>Brain injury</subject><subject>Care and treatment</subject><subject>Case-Control Studies</subject><subject>Complications and side effects</subject><subject>Computed tomography</subject><subject>Control</subject><subject>Cooling</subject><subject>Diagnosis</subject><subject>Encephalopathy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gestational Age</subject><subject>Head</subject><subject>Head injuries</subject><subject>Humans</subject><subject>Hypothermia</subject><subject>Hypothermia, Induced - methods</subject><subject>Hypoxia</subject><subject>Hypoxia, Brain - prevention & control</subject><subject>Infant, Newborn</subject><subject>Intensive Care Units, Neonatal</subject><subject>Ischemia</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neonates</subject><subject>Neuroprotection</subject><subject>Newborn babies</subject><subject>original-article</subject><subject>Patients</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Pregnancy</subject><subject>Prognosis</subject><subject>Reference Values</subject><subject>Risk Assessment</subject><subject>Risk factors</subject><subject>Sensitivity and Specificity</subject><subject>Severity of Illness Index</subject><subject>Suffocation</subject><subject>Survival Rate</subject><subject>Therapy</subject><subject>Treatment Outcome</subject><issn>0743-8346</issn><issn>1476-5543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kk9v1DAQxSMEotvCkSPIolI5ZbHjJE64VRX_pCIucI4cZ7JxlNjBdkr3I_EtmWgDSxFFURQ57_fezMgTRc8Y3TLKi9e-3_bTViSMpSx5EG1YKvI4y1L-MNpQkfK44Gl-Ep1631O6iOJxdMLylIoyF5voxyc9NKTbTzZ04EYtyQ2-HgZQQd8A6UA2RFk7aLMj0hMDs7OTs2HVF5ec9kQbEtCPujUygCffdejIBE7jUQ5onbr9rZZviDQEbhcBjALSOjsSLIjxA6xuxLUJYPxSQEkHZDY6PIketXLw8HT9nkVf3739cvUhvv78_uPV5XWsMi5CDBRwtprnpYCikHWa5KnIoMXheZaUicrqUgEDprjiZZ0zaJIkS-uGJawuec3PoleHXJzy2ww-VKP2CoZBYnezr0SWMc5EypC8-C-Zi7woi5IieP4X2NvZGZyiwu5oVuYJK5B6eS-VULxdQctj1E4OUGnT2uCkWupWl5jBuUjEErX9B4VPA6NW1kCr8f8dw8UfBrz0IXTeDnPQ1vi7YHwAlbPeO2iryelRun3FaLUsZOX7qp-qdSGRf7EONdcjNEd63cBjqx4lswN3nPq-xOcHA27K7OB34i_9J5Jw9RI</recordid><startdate>200603</startdate><enddate>200603</enddate><creator>Lin, Z-L</creator><creator>Yu, H-M</creator><creator>Lin, J</creator><creator>Chen, S-Q</creator><creator>Liang, Z-Q</creator><creator>Zhang, Z-Y</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>200603</creationdate><title>Mild hypothermia via selective head cooling as neuroprotective therapy in term neonates with perinatal asphyxia: an experience from a single neonatal intensive care unit</title><author>Lin, Z-L ; Yu, H-M ; Lin, J ; Chen, S-Q ; Liang, Z-Q ; Zhang, Z-Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c537t-e0e407b3697e88ab426475ef00135292c5b9ce1e1c3c39b61ed2254bd121b93b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Apgar Score</topic><topic>Asphyxia</topic><topic>Asphyxia neonatorum</topic><topic>Asphyxia Neonatorum - diagnosis</topic><topic>Asphyxia Neonatorum - therapy</topic><topic>Brain</topic><topic>Brain damage</topic><topic>Brain injury</topic><topic>Care and treatment</topic><topic>Case-Control Studies</topic><topic>Complications and side effects</topic><topic>Computed tomography</topic><topic>Control</topic><topic>Cooling</topic><topic>Diagnosis</topic><topic>Encephalopathy</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gestational Age</topic><topic>Head</topic><topic>Head injuries</topic><topic>Humans</topic><topic>Hypothermia</topic><topic>Hypothermia, Induced - methods</topic><topic>Hypoxia</topic><topic>Hypoxia, Brain - prevention & control</topic><topic>Infant, Newborn</topic><topic>Intensive Care Units, Neonatal</topic><topic>Ischemia</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neonates</topic><topic>Neuroprotection</topic><topic>Newborn babies</topic><topic>original-article</topic><topic>Patients</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Pregnancy</topic><topic>Prognosis</topic><topic>Reference Values</topic><topic>Risk Assessment</topic><topic>Risk factors</topic><topic>Sensitivity and Specificity</topic><topic>Severity of Illness Index</topic><topic>Suffocation</topic><topic>Survival Rate</topic><topic>Therapy</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Z-L</creatorcontrib><creatorcontrib>Yu, H-M</creatorcontrib><creatorcontrib>Lin, J</creatorcontrib><creatorcontrib>Chen, S-Q</creatorcontrib><creatorcontrib>Liang, Z-Q</creatorcontrib><creatorcontrib>Zhang, Z-Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of Perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Z-L</au><au>Yu, H-M</au><au>Lin, J</au><au>Chen, S-Q</au><au>Liang, Z-Q</au><au>Zhang, Z-Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mild hypothermia via selective head cooling as neuroprotective therapy in term neonates with perinatal asphyxia: an experience from a single neonatal intensive care unit</atitle><jtitle>Journal of Perinatology</jtitle><stitle>J Perinatol</stitle><addtitle>J Perinatol</addtitle><date>2006-03</date><risdate>2006</risdate><volume>26</volume><issue>3</issue><spage>180</spage><epage>184</epage><pages>180-184</pages><issn>0743-8346</issn><eissn>1476-5543</eissn><abstract>Objective:
The objective of this study was to determine the efficacy of mild hypothermia via selective head cooling as a neuroprotective therapy in term infants with perinatal asphyxia.
Study design:
Full-term newborns who had 5 min Apgar scores <6, first arterial blood gas pH<7.10 or BD>15 mEq/l, and with the clinical signs of encephalopathy were enrolled within 6 h after birth. Patients were randomized to receive mild hypothermia treatment via selective head cooling for a total of 72 h or receive routine treatment as a control. Brain hypoxic-ischemic injury was quantified based on the head computed tomographic scan (CT scan) at postnatal age 5–7 days and a Neonatal Behavioral Neurological Assessment (NBNA) score at 7–10 days of life.
Results:
A total of 58 patients (30 hypothermia, 28 control) completed the study. Hypothermia was well tolerated in this study and attenuated the hypoxic-ischemic brain injury due to perinatal asphyxia. Head CT scan demonstrated moderate to severe hypoxic-ischemic changes in only 4/30 cases from the hypothermic group. In contrast, 18/28 cases in the control group showed moderate to severe hypoxic-ischemic changes (
χ
2
=15.97,
P
<0.01). Brain hypothermia also significantly improved the NBNA score (32±2 in the hypothermic group vs 28±3 in the control group,
P
<0.01).
Conclusion
s: Our results suggest that selective head cooling may be used as a neuroprotective therapy in term neonates with perinatal asphyxia. A long-term follow-up study is needed to further validate the results of this study.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>16407967</pmid><doi>10.1038/sj.jp.7211412</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0743-8346 |
| ispartof | Journal of Perinatology, 2006-03, Vol.26 (3), p.180-184 |
| issn | 0743-8346 1476-5543 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_755131741 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; SpringerLink Journals - AutoHoldings |
| subjects | Apgar Score Asphyxia Asphyxia neonatorum Asphyxia Neonatorum - diagnosis Asphyxia Neonatorum - therapy Brain Brain damage Brain injury Care and treatment Case-Control Studies Complications and side effects Computed tomography Control Cooling Diagnosis Encephalopathy Female Follow-Up Studies Gestational Age Head Head injuries Humans Hypothermia Hypothermia, Induced - methods Hypoxia Hypoxia, Brain - prevention & control Infant, Newborn Intensive Care Units, Neonatal Ischemia Male Medical imaging Medicine Medicine & Public Health Neonates Neuroprotection Newborn babies original-article Patients Pediatric Surgery Pediatrics Pregnancy Prognosis Reference Values Risk Assessment Risk factors Sensitivity and Specificity Severity of Illness Index Suffocation Survival Rate Therapy Treatment Outcome |
| title | Mild hypothermia via selective head cooling as neuroprotective therapy in term neonates with perinatal asphyxia: an experience from a single neonatal intensive care unit |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T07%3A34%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mild%20hypothermia%20via%20selective%20head%20cooling%20as%20neuroprotective%20therapy%20in%20term%20neonates%20with%20perinatal%20asphyxia:%20an%20experience%20from%20a%20single%20neonatal%20intensive%20care%20unit&rft.jtitle=Journal%20of%20Perinatology&rft.au=Lin,%20Z-L&rft.date=2006-03&rft.volume=26&rft.issue=3&rft.spage=180&rft.epage=184&rft.pages=180-184&rft.issn=0743-8346&rft.eissn=1476-5543&rft_id=info:doi/10.1038/sj.jp.7211412&rft_dat=%3Cgale_proqu%3EA183337278%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=220412709&rft_id=info:pmid/16407967&rft_galeid=A183337278&rfr_iscdi=true |