Evolution of the bacterial dihydrofolate reductase inhibitors

Trimethoprim was put forward as a potentiator of sulphonamides for the treatment of bacterial infections: sulphamethoxazole was chosen as the sulphonamide owing matched half-life of trimethoprim. It was argued that the combination of sulphamethoxazole and trimethoprim, later given the name co-trimox...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 1995-12, Vol.36 (6), p.887-890
1. Verfasser:	Periti, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Infective Agents - pharmacology Anti-Infective Agents, Urinary - pharmacology Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - drug effects Enzyme Inhibitors - pharmacology Folic Acid Antagonists - pharmacology Trimethoprim - pharmacology
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