Inhibition of sodium and potassium adenosine triphosphatase by 2',3'-O-(2,4,6-trinitrocyclohexadienylidene) adenine nucleotides. Implications for the structure and mechanism of the Na:K pump

Trinitrophenyl derivatives of adenine nucleotides (TNP-nucleotides: 2',3'-O-2,4,6-trinitrocyclohexadienylidene complexes at neutral or basic pH) are potent inhibitors of (Na,K)-ATPase activity. The inhibitory potency of the derivatives tested followed the sequence: TNP-ADP greater than TNP...

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Veröffentlicht in:	The Journal of biological chemistry 1981-03, Vol.256 (5), p.2357-2366
Hauptverfasser:	Moczydlowski, E G, Fortes, P A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Nucleotides - pharmacology Animals Biological Transport, Active Eels Electric Organ - enzymology Kinetics Mathematics Potassium - metabolism Sodium - metabolism Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors Structure-Activity Relationship
Online-Zugang:	Volltext
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