Curare-Like Activity of Some Bis-Fluorenyl-Bis-Quaternary Ammonium Compounds
Conclusions 1. The curariform activity of a new series of bis-quaternary ammonium compounds is reported. 2. Moderate increase of activity is obtained by shortening the distance between nitrogen atoms from approximately 15 Å to 9 Å. 3. Replacement of N-ethyl groups with N-methyl in the 6-carbon chain...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1954-04, Vol.85 (4), p.603-606 |
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| container_issue | 4 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 85 |
| creator | Macri, Frank J. |
| description | Conclusions
1. The curariform activity of a new series of bis-quaternary ammonium compounds is reported. 2. Moderate increase of activity is obtained by shortening the distance between nitrogen atoms from approximately 15 Å to 9 Å. 3. Replacement of N-ethyl groups with N-methyl in the 6-carbon chain analog decreases both the activity and the subcutaneous absorption in mice, but has no effect on the activity as measured in dogs and rabbits. |
| doi_str_mv | 10.3181/00379727-85-20966 |
| format | Article |
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1. The curariform activity of a new series of bis-quaternary ammonium compounds is reported. 2. Moderate increase of activity is obtained by shortening the distance between nitrogen atoms from approximately 15 Å to 9 Å. 3. Replacement of N-ethyl groups with N-methyl in the 6-carbon chain analog decreases both the activity and the subcutaneous absorption in mice, but has no effect on the activity as measured in dogs and rabbits.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-85-20966</identifier><identifier>PMID: 13167153</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Cardiovascular Agents ; Curare ; Dermatologic Agents ; Muscle Relaxants, Central ; Old Medline ; Quaternary Ammonium Compounds</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1954-04, Vol.85 (4), p.603-606</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-78fedcf5a3eae7b11df7b37fff1712b6a0d941279f6385cbb612eadb45963b293</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13167153$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Macri, Frank J.</creatorcontrib><title>Curare-Like Activity of Some Bis-Fluorenyl-Bis-Quaternary Ammonium Compounds</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Conclusions
1. The curariform activity of a new series of bis-quaternary ammonium compounds is reported. 2. Moderate increase of activity is obtained by shortening the distance between nitrogen atoms from approximately 15 Å to 9 Å. 3. Replacement of N-ethyl groups with N-methyl in the 6-carbon chain analog decreases both the activity and the subcutaneous absorption in mice, but has no effect on the activity as measured in dogs and rabbits.</description><subject>Cardiovascular Agents</subject><subject>Curare</subject><subject>Dermatologic Agents</subject><subject>Muscle Relaxants, Central</subject><subject>Old Medline</subject><subject>Quaternary Ammonium Compounds</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1954</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LwzAUhoMobk5_gDfSK-8y87EkzeUcToWCiHodkjaRzraZSSPs39u6iXdeHQ7neV8ODwCXGM0pzvENQlRIQQTMGSRIcn4EpphRBimX8hhMxzscgQk4i3GDEGaC8FMwwRRzMZBTUKxS0MHCov6w2bLs66-632XeZS--tdltHeG6ST7YbtfAcXtOureh02GXLdvWd3Vqs5Vvtz51VTwHJ0430V4c5gy8re9eVw-weLp_XC0LWFKa91DkzlalY5pabYXBuHLCUOGcwwITwzWq5AITIR2nOSuN4ZhYXZkFk5waIukMXO97t8F_Jht71daxtE2jO-tTVIItJJGYDCDeg2XwMQbr1DbU7fC8wkiNCtWvQpUz9aNwyFwdypNpbfWXODgbgPkeiPrdqo1Pg44m_tP4DYEkeew</recordid><startdate>195404</startdate><enddate>195404</enddate><creator>Macri, Frank J.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>195404</creationdate><title>Curare-Like Activity of Some Bis-Fluorenyl-Bis-Quaternary Ammonium Compounds</title><author>Macri, Frank J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-78fedcf5a3eae7b11df7b37fff1712b6a0d941279f6385cbb612eadb45963b293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1954</creationdate><topic>Cardiovascular Agents</topic><topic>Curare</topic><topic>Dermatologic Agents</topic><topic>Muscle Relaxants, Central</topic><topic>Old Medline</topic><topic>Quaternary Ammonium Compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Macri, Frank J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Macri, Frank J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Curare-Like Activity of Some Bis-Fluorenyl-Bis-Quaternary Ammonium Compounds</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1954-04</date><risdate>1954</risdate><volume>85</volume><issue>4</issue><spage>603</spage><epage>606</epage><pages>603-606</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Conclusions
1. The curariform activity of a new series of bis-quaternary ammonium compounds is reported. 2. Moderate increase of activity is obtained by shortening the distance between nitrogen atoms from approximately 15 Å to 9 Å. 3. Replacement of N-ethyl groups with N-methyl in the 6-carbon chain analog decreases both the activity and the subcutaneous absorption in mice, but has no effect on the activity as measured in dogs and rabbits.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>13167153</pmid><doi>10.3181/00379727-85-20966</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1954-04, Vol.85 (4), p.603-606 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75492912 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Cardiovascular Agents Curare Dermatologic Agents Muscle Relaxants, Central Old Medline Quaternary Ammonium Compounds |
| title | Curare-Like Activity of Some Bis-Fluorenyl-Bis-Quaternary Ammonium Compounds |
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