Mole maker phenotype: possible narrowing of the candidate region
Recent data has suggested that familial recurrent hydatidiform mole is a rare autosomal recessive trait in women experiencing this gestational disease (MIM 231090). Here we provide molecular data on an additional family confirming that recurrent familial hydatidiform moles are diploid, biparental an...
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| Veröffentlicht in: | European journal of human genetics : EJHG 2000-08, Vol.8 (8), p.641-644 |
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| container_title | European journal of human genetics : EJHG |
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| creator | Sensi, A Gualandi, F Pittalis, M C Calabrese, O Falciano, F Maestri, I Bovicelli, L Calzolari, E |
| description | Recent data has suggested that familial recurrent hydatidiform mole is a rare autosomal recessive trait in women experiencing this gestational disease (MIM 231090). Here we provide molecular data on an additional family confirming that recurrent familial hydatidiform moles are diploid, biparental and arise from independent conceptions. A narrowing of the gene interval on chromosome 19q13.3-13.4 is suggested by haplotype analysis in two sisters. |
| doi_str_mv | 10.1038/sj.ejhg.5200501 |
| format | Article |
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Here we provide molecular data on an additional family confirming that recurrent familial hydatidiform moles are diploid, biparental and arise from independent conceptions. 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| subjects | Adult Chromosome 19 Chromosome Aberrations Chromosome Disorders Chromosome Mapping Chromosomes Chromosomes, Human, Pair 19 - genetics Family Health Female Flow cytometry Genetic Linkage Genetics Genomes Haplotypes Homozygote Humans Hydatidiform mole Hydatidiform Mole - genetics Lod Score Male Microsatellite Repeats Pedigree Phenotypes Ploidies Pregnancy Recessive traits Sequence Tagged Sites Uterine Neoplasms - genetics Womens health |
| title | Mole maker phenotype: possible narrowing of the candidate region |
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