Outcome and toxicity associated with a dose-intensified, maintenance-free CHOP-based chemotherapy protocol in canine lymphoma: 130 cases

A dose-intensified/dose-dense chemotherapy protocol for canine lymphoma was designed and implemented at the Veterinary Hospital of the University of Pennsylvania. In this study, we describe the clinical characteristics, prognostic factors, efficacy and toxicity in 130 dogs treated with this protocol...

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Veröffentlicht in:	Veterinary & comparative oncology 2010-09, Vol.8 (3), p.196-208
Hauptverfasser:	Sorenmo, K, Overley, B, Krick, E, Ferrara, T, LaBlanc, A, Shofer, F
Format:	Artikel
Sprache:	eng
Schlagworte:	adverse effects Animals antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Asparaginase - administration & dosage Asparaginase - adverse effects chemotherapy combination drug therapy Cyclophosphamide - adverse effects Cyclophosphamide - therapeutic use disease course dog diseases Dog Diseases - drug therapy Dog Diseases - mortality Dogs dosage dose response Doxorubicin - adverse effects Doxorubicin - therapeutic use drug toxicity Female lymphoma Lymphoma - drug therapy Lymphoma - mortality Lymphoma - veterinary Male Methotrexate - administration & dosage Methotrexate - adverse effects mortality Neoplasm Staging Prednisone - adverse effects Prednisone - therapeutic use Prognosis Retrospective Studies summation dose density Survival Analysis Treatment Outcome Vincristine - adverse effects Vincristine - therapeutic use
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