Identification and consequences of galectin-3 expression in pituitary tumors
Although the mechanisms regulating pituitary tumor development and progression are still unclear, new information on the molecular mechanisms involved in the pathogenesis of human pituitary tumors have accumulated. Recent evidence suggests that galectin-3 plays an important role in pituitary tumorig...
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| Veröffentlicht in: | Molecular and cellular endocrinology 2010-09, Vol.326 (1), p.8-14 |
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| container_title | Molecular and cellular endocrinology |
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| creator | Righi, A. Jin, L. Zhang, S. Stilling, G. Scheithauer, B.W. Kovacs, K. Lloyd, R.V. |
| description | Although the mechanisms regulating pituitary tumor development and progression are still unclear, new information on the molecular mechanisms involved in the pathogenesis of human pituitary tumors have accumulated. Recent evidence suggests that galectin-3 plays an important role in pituitary tumorigenesis and in tumor progression. Galectin-3 is expressed in a variety of tumors and the intensity of expression and localization depend on tumor progression, invasiveness and metastatic potential. Galectin-3 expression has been used as a potential diagnostic and/or prognostic marker in a variety of neoplasms. This review summarizes existing information regarding the structural and functional properties of galectin-3 protein as well as the LGALS3 gene in pituitary tumorigenesis. Given its role in pituitary tumor cell proliferation and in apoptosis, galectin-3 may be a target for the treatment of aggressive pituitary tumors. |
| doi_str_mv | 10.1016/j.mce.2010.04.026 |
| format | Article |
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Recent evidence suggests that galectin-3 plays an important role in pituitary tumorigenesis and in tumor progression. Galectin-3 is expressed in a variety of tumors and the intensity of expression and localization depend on tumor progression, invasiveness and metastatic potential. Galectin-3 expression has been used as a potential diagnostic and/or prognostic marker in a variety of neoplasms. This review summarizes existing information regarding the structural and functional properties of galectin-3 protein as well as the LGALS3 gene in pituitary tumorigenesis. Given its role in pituitary tumor cell proliferation and in apoptosis, galectin-3 may be a target for the treatment of aggressive pituitary tumors.</description><identifier>ISSN: 0303-7207</identifier><identifier>EISSN: 1872-8057</identifier><identifier>DOI: 10.1016/j.mce.2010.04.026</identifier><identifier>PMID: 20451577</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>ACTH adenoma ; Adrenocorticotropic Hormone - secretion ; Animals ; Apoptosis - genetics ; Carcinoma - pathology ; Core Binding Factor Alpha 1 Subunit - metabolism ; Core Binding Factor Alpha 2 Subunit - metabolism ; Folliculo-stellate cells ; Galectin 3 - biosynthesis ; Galectin 3 - metabolism ; Galectin-3 ; Humans ; Methylation ; Mice ; Pituitary ; Pituitary Gland - pathology ; Pituitary Neoplasms - genetics ; Pituitary Neoplasms - metabolism ; Pituitary Neoplasms - pathology ; PRL adenoma ; Tumor</subject><ispartof>Molecular and cellular endocrinology, 2010-09, Vol.326 (1), p.8-14</ispartof><rights>2010 Elsevier Ireland Ltd</rights><rights>2010 Elsevier Ireland Ltd. 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Recent evidence suggests that galectin-3 plays an important role in pituitary tumorigenesis and in tumor progression. Galectin-3 is expressed in a variety of tumors and the intensity of expression and localization depend on tumor progression, invasiveness and metastatic potential. Galectin-3 expression has been used as a potential diagnostic and/or prognostic marker in a variety of neoplasms. This review summarizes existing information regarding the structural and functional properties of galectin-3 protein as well as the LGALS3 gene in pituitary tumorigenesis. Given its role in pituitary tumor cell proliferation and in apoptosis, galectin-3 may be a target for the treatment of aggressive pituitary tumors.</description><subject>ACTH adenoma</subject><subject>Adrenocorticotropic Hormone - secretion</subject><subject>Animals</subject><subject>Apoptosis - genetics</subject><subject>Carcinoma - pathology</subject><subject>Core Binding Factor Alpha 1 Subunit - metabolism</subject><subject>Core Binding Factor Alpha 2 Subunit - metabolism</subject><subject>Folliculo-stellate cells</subject><subject>Galectin 3 - biosynthesis</subject><subject>Galectin 3 - metabolism</subject><subject>Galectin-3</subject><subject>Humans</subject><subject>Methylation</subject><subject>Mice</subject><subject>Pituitary</subject><subject>Pituitary Gland - pathology</subject><subject>Pituitary Neoplasms - genetics</subject><subject>Pituitary Neoplasms - metabolism</subject><subject>Pituitary Neoplasms - pathology</subject><subject>PRL adenoma</subject><subject>Tumor</subject><issn>0303-7207</issn><issn>1872-8057</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKAzEUhoMotlYfwI3MztWMmVwmKa6keCkU3HQfMskZSZlLTTKib2-GVpe6Ohz4_p9zPoSuS1yUuKzudkVnoCA47ZgVmFQnaF5KQXKJuThFc0wxzQXBYoYuQthhjAUn8hzNCGa85ELM0WZtoY-ucUZHN_SZ7m1mhj7A-wi9gZANTfamWzDR9TnN4HPvIYSJdH22d3F0UfuvLI7d4MMlOmt0G-DqOBdo-_S4Xb3km9fn9ephkxsqWcwZEdxWS1rJiphKMgEaWyJrLYnWNRjWsKaRQnIjJZENtwJqBhIo09pwTRfo9lC790M6M0TVuWCgbXUPwxiU4EwuK0ro_-QEpnOWiSwPpPFDCB4atfeuS6-pEqtJttqpJFtNshVmKslOmZtj-1h3YH8TP3YTcH8AIMn4cOBVMG7Sap1PRpUd3B_1303vkBQ</recordid><startdate>20100915</startdate><enddate>20100915</enddate><creator>Righi, A.</creator><creator>Jin, L.</creator><creator>Zhang, S.</creator><creator>Stilling, G.</creator><creator>Scheithauer, B.W.</creator><creator>Kovacs, K.</creator><creator>Lloyd, R.V.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>7TO</scope><scope>H94</scope></search><sort><creationdate>20100915</creationdate><title>Identification and consequences of galectin-3 expression in pituitary tumors</title><author>Righi, A. ; 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| fulltext | fulltext |
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| ispartof | Molecular and cellular endocrinology, 2010-09, Vol.326 (1), p.8-14 |
| issn | 0303-7207 1872-8057 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | ACTH adenoma Adrenocorticotropic Hormone - secretion Animals Apoptosis - genetics Carcinoma - pathology Core Binding Factor Alpha 1 Subunit - metabolism Core Binding Factor Alpha 2 Subunit - metabolism Folliculo-stellate cells Galectin 3 - biosynthesis Galectin 3 - metabolism Galectin-3 Humans Methylation Mice Pituitary Pituitary Gland - pathology Pituitary Neoplasms - genetics Pituitary Neoplasms - metabolism Pituitary Neoplasms - pathology PRL adenoma Tumor |
| title | Identification and consequences of galectin-3 expression in pituitary tumors |
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