Toxic Effect of Cyclophosphamide on Sperm Morphology, Testicular Histology and Blood Oxidant‐Antioxidant Balance, and Protective Roles of Lycopene and Ellagic Acid

: In this study, the toxic effect of cyclophosphamide (CP) on sperm morphology, testicular histology and blood oxidant–antioxidant balance, and protective roles of lycopene (LC) and ellagic acid (EA) were investigated. For this purpose, 48 healthy, adult, male Sprague‐Dawley rats were divided into...

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Veröffentlicht in:	Basic & clinical pharmacology & toxicology 2010-09, Vol.107 (3), p.730-736
Hauptverfasser:	Çeribaşi, Ali Osman, Türk, Gaffari, Sönmez, Mustafa, Sakin, Fatih, Ateşşahin, Ahmet
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Alkylating - toxicity Antioxidants - metabolism Atrophy Biological and medical sciences Blood Carotenoids - therapeutic use Catalase Catalase - metabolism Cyclophosphamide Cyclophosphamide - toxicity Degeneration ellagic acid Ellagic Acid - therapeutic use Erythrocytes Erythrocytes - metabolism Germ cells Glutathione Glutathione - blood Glutathione Peroxidase - metabolism Lipid peroxidation lycopene Male Malondialdehyde Malondialdehyde - blood Medical sciences Necrosis Oxidants - metabolism Pharmacology. Drug treatments Protective Agents - therapeutic use Rats Rats, Sprague-Dawley Seminiferous tubule Sperm Spermatozoa - drug effects Spermatozoa - pathology Statistical analysis Superoxide dismutase Superoxide Dismutase - metabolism Tails Testes Testis - drug effects Testis - pathology
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