Chronobiological features of the immune system. Effect of calorie restriction

The circadian organization of living organisms is fully established being a key component the activity of the neuro-endocrin-immune system that maintains the homeostasis. Secondary lymph organs, such as submaxillary lymph nodes and spleen, have been shown to exhibit a 24 h variation in blastogenic p...

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Veröffentlicht in:European journal of clinical nutrition 2002-08, Vol.56 Suppl 3 (S3), p.S69-S72
Hauptverfasser: Chacón, F, Cano, P, Lopez-Varela, S, Jiménez, V, Marcos, A, Esquifino, A I
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container_end_page S72
container_issue S3
container_start_page S69
container_title European journal of clinical nutrition
container_volume 56 Suppl 3
creator Chacón, F
Cano, P
Lopez-Varela, S
Jiménez, V
Marcos, A
Esquifino, A I
description The circadian organization of living organisms is fully established being a key component the activity of the neuro-endocrin-immune system that maintains the homeostasis. Secondary lymph organs, such as submaxillary lymph nodes and spleen, have been shown to exhibit a 24 h variation in blastogenic proliferative capacity and distribution of B and T subsets, with specific achrophases depending on the parameter studied or the lymphoid organ considered. However, less is known about the thymus. The immune system has been shown to change by calorie restriction, although no information is available about possible effects in 24 h variations. Similar questions can be posed for the neuro-endocrine system. As an example, some data are shown in this article about the effects of calorie restriction on the neuro-endocrin-immune system in growing male Wistar rats. Calorie restriction blunted the circadian secretory pattern of TSH observed in the control group that was characterized by the existence of two peaks at 17:00 or 01:00 h and that explained the low basal metabolic rate of these animals under this experimental condition. Concerning the immune system, the thymus gland exhibited 24 h variations in T, B and immature cells in both control and calorie-restricted male rats, thus confirming the circadian organization of the immune system. Moreover this circadian organization was changed by calorie restriction.
doi_str_mv 10.1038/sj.ejcn.1601491
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1476-5640
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source MEDLINE; Nature; Free E-Journal (出版社公開部分のみ); Alma/SFX Local Collection
subjects Animals
Calories
Circadian Rhythm - immunology
Circadian rhythms
Clinical nutrition
Diet
Diet, Reducing - adverse effects
Endocrine Glands - cytology
Endocrine Glands - immunology
Endocrine system
Female
Food Deprivation
Homeostasis
Humans
Immune system
Immune System - immunology
Immune System - physiology
Immunology
Lymph nodes
Male
Males
Metabolic rate
Neuroendocrine system
Neurosecretory Systems - immunology
Neurosecretory Systems - physiology
Nutrient deficiency
Nutrition
Organs
Properties
Rats
Rats, Wistar
Rodents
Spleen
Thymus
Thymus gland
Thymus Gland - immunology
Thymus Gland - physiology
Thyrotropin
Variation
title Chronobiological features of the immune system. Effect of calorie restriction
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