unusual loss of EGFR gene copy in glioblastoma multiforme in a child: a case report and analysis of a successfully derived HGG-02 cell line

Purpose The aim of this study was to perform a detailed cytogenetic and molecular genetic analysis of a tumor taken from a 14.5-year-old boy with glioblastoma multiforme who showed an atypical clinical course. Methods Formalin-fixed, paraffin embedded tumor tissue and the corresponding HGG-02 cell l...

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Veröffentlicht in:	Child's nervous system 2010-06, Vol.26 (6), p.841-846
Hauptverfasser:	Veselska, Renata, Skoda, Jan, Loja, Tomas, Zitterbart, Karel, Pavelka, Zdenek, Smardova, Jana, Valaskova, Iveta, Hermanova, Marketa, Sterba, Jaroslav
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adolescent Brain - metabolism Brain - pathology Brain Neoplasms - genetics Brain Neoplasms - pathology Brain Neoplasms - therapy Case Report Cell Line, Tumor Disease Progression EGFR FASAY fish Gene Dosage Genes, p53 Glioblastoma - genetics Glioblastoma - pathology Glioblastoma - therapy Glioblastoma multiforme Humans karyotyping Male Medicine Medicine & Public Health Mutation MutL Protein Homolog 1 Neurosciences Neurosurgery Nuclear Proteins - genetics p53 Phenotype Receptor, Epidermal Growth Factor - genetics Treatment Outcome
Online-Zugang:	Volltext
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