Systemic Administration of Proteasome Inhibitor Protects Against MPTP Neurotoxicity in Mice

Dysfunction of the proteasome has been suggested to contribute in the degeneration of nigrostriatal dopaminergic neurons. Here, we investigated to determine whether systematic administration of proteasome inhibitor, carbobenzoxy-l-γ-t-butyl-l-glutamyl-l-alanyl-l-leucinal (PSI) protects against MPTP...

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Veröffentlicht in:	Cellular and molecular neurobiology 2009-07, Vol.29 (5), p.769-777
Hauptverfasser:	Oshikawa, Takuya, Kuroiwa, Hayato, Yano, Ryohei, Yokoyama, Hironori, Kadoguchi, Naoto, Kato, Hiroyuki, Araki, Tsutomu
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology Animals Biomedical and Life Sciences Biomedicine Blotting, Western Cell Biology Chromatography, High Pressure Liquid Dopamine - metabolism Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - pharmacology Glial Fibrillary Acidic Protein - metabolism Immunohistochemistry Male Mice Mice, Inbred C57BL Neostriatum - cytology Neostriatum - drug effects Neostriatum - enzymology Neurobiology Neurons - cytology Neurons - drug effects Neurons - enzymology Neurosciences Original Research Proteasome Inhibitors Substantia Nigra - cytology Substantia Nigra - drug effects Substantia Nigra - metabolism Tyrosine 3-Monooxygenase - metabolism Ubiquitin - metabolism
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