Prothrombin G20210A mutation in cases with recurrent miscarriage: a study of the mediterranean population
Thrombophilic predisposition may be one of the underlying causes of recurrent miscariage (RM). The purpose of this study was to evaluate the Prothrombin G20210A mutation in cases with history of RM. A total of 104 cases, 55 with diagnosis of RM and 49 control cases, were included in this controlled...
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| Veröffentlicht in: | Archives of gynecology and obstetrics 2005-12, Vol.273 (3), p.170-173 |
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| creator | Sehirali, Salim Inal, M Murat Yildirim, Yusuf Balim, Zuhal Kosova, Buket Karamizrak, Tulin Sanci, Muzaffer Topcuoglu, Nejat Tinar, Sivekar |
| description | Thrombophilic predisposition may be one of the underlying causes of recurrent miscariage (RM). The purpose of this study was to evaluate the Prothrombin G20210A mutation in cases with history of RM.
A total of 104 cases, 55 with diagnosis of RM and 49 control cases, were included in this controlled study. In all cases, in addition to full examination tests, Prothrombin 20210A mutation analysis was carried out by means of Polymerase Chain Reaction (PCR).
Mean number of the abortion was 3.51 +/- 0.74 in the RM group and 0.08 +/- 0.27 in the control group (p < 0.05). As a consequence of comprehensive examinations, in 24 (43.6%) of 55 RM cases at least one etiologic factor was put forth. Prothrombin G20210A mutation was observed in six (10.9%) cases of the RM group and one (2.04%) in the control group (p < 0.05). Four of the six cases (66.7%) of Prothrombin G20210A mutation had a subsequent pregnancy. Among these four pregnancies, there was one spontaneous loss at 14 weeks of gestation and one severe pre-eclampsia.
Our data together with literature suggest that Prothrombin G20210A mutation may be associated with RM. We recommend this genetic testing as a screening tool for women with history of RM. |
| doi_str_mv | 10.1007/s00404-005-0061-7 |
| format | Article |
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A total of 104 cases, 55 with diagnosis of RM and 49 control cases, were included in this controlled study. In all cases, in addition to full examination tests, Prothrombin 20210A mutation analysis was carried out by means of Polymerase Chain Reaction (PCR).
Mean number of the abortion was 3.51 +/- 0.74 in the RM group and 0.08 +/- 0.27 in the control group (p < 0.05). As a consequence of comprehensive examinations, in 24 (43.6%) of 55 RM cases at least one etiologic factor was put forth. Prothrombin G20210A mutation was observed in six (10.9%) cases of the RM group and one (2.04%) in the control group (p < 0.05). Four of the six cases (66.7%) of Prothrombin G20210A mutation had a subsequent pregnancy. Among these four pregnancies, there was one spontaneous loss at 14 weeks of gestation and one severe pre-eclampsia.
Our data together with literature suggest that Prothrombin G20210A mutation may be associated with RM. We recommend this genetic testing as a screening tool for women with history of RM.</description><identifier>ISSN: 0932-0067</identifier><identifier>EISSN: 1432-0711</identifier><identifier>DOI: 10.1007/s00404-005-0061-7</identifier><identifier>PMID: 16189694</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Abortion, Habitual - genetics ; Adult ; Case-Control Studies ; European Continental Ancestry Group - genetics ; Female ; Genetic Predisposition to Disease ; Humans ; Mediterranean Region ; Mutation ; Pregnancy ; Prothrombin - genetics ; Turkey - epidemiology</subject><ispartof>Archives of gynecology and obstetrics, 2005-12, Vol.273 (3), p.170-173</ispartof><rights>Archives of Gynecology and Obstetrics is a copyright of Springer, (2005). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c274t-2b5fe9d68d83534315d8ad9f92c422b3799c68828e3c739a18af5d0c604d904d3</citedby><cites>FETCH-LOGICAL-c274t-2b5fe9d68d83534315d8ad9f92c422b3799c68828e3c739a18af5d0c604d904d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16189694$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sehirali, Salim</creatorcontrib><creatorcontrib>Inal, M Murat</creatorcontrib><creatorcontrib>Yildirim, Yusuf</creatorcontrib><creatorcontrib>Balim, Zuhal</creatorcontrib><creatorcontrib>Kosova, Buket</creatorcontrib><creatorcontrib>Karamizrak, Tulin</creatorcontrib><creatorcontrib>Sanci, Muzaffer</creatorcontrib><creatorcontrib>Topcuoglu, Nejat</creatorcontrib><creatorcontrib>Tinar, Sivekar</creatorcontrib><title>Prothrombin G20210A mutation in cases with recurrent miscarriage: a study of the mediterranean population</title><title>Archives of gynecology and obstetrics</title><addtitle>Arch Gynecol Obstet</addtitle><description>Thrombophilic predisposition may be one of the underlying causes of recurrent miscariage (RM). The purpose of this study was to evaluate the Prothrombin G20210A mutation in cases with history of RM.
A total of 104 cases, 55 with diagnosis of RM and 49 control cases, were included in this controlled study. In all cases, in addition to full examination tests, Prothrombin 20210A mutation analysis was carried out by means of Polymerase Chain Reaction (PCR).
Mean number of the abortion was 3.51 +/- 0.74 in the RM group and 0.08 +/- 0.27 in the control group (p < 0.05). As a consequence of comprehensive examinations, in 24 (43.6%) of 55 RM cases at least one etiologic factor was put forth. Prothrombin G20210A mutation was observed in six (10.9%) cases of the RM group and one (2.04%) in the control group (p < 0.05). Four of the six cases (66.7%) of Prothrombin G20210A mutation had a subsequent pregnancy. Among these four pregnancies, there was one spontaneous loss at 14 weeks of gestation and one severe pre-eclampsia.
Our data together with literature suggest that Prothrombin G20210A mutation may be associated with RM. We recommend this genetic testing as a screening tool for women with history of RM.</description><subject>Abortion, Habitual - genetics</subject><subject>Adult</subject><subject>Case-Control Studies</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Mediterranean Region</subject><subject>Mutation</subject><subject>Pregnancy</subject><subject>Prothrombin - genetics</subject><subject>Turkey - epidemiology</subject><issn>0932-0067</issn><issn>1432-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kUtLxDAUhYMoOj5-gBsJCLqq3jzaJO5EdBQEXeg6ZNLU6TBtxiRF5t-bOgOCCxeXhPDl5OQchE4JXBEAcR0BOPACoMxTkULsoAnhjBYgCNlFE1DjHipxgA5jXAAQKmW1jw5IRaSqFJ-g9jX4NA--m7U9nlKgBG5xNySTWt_jfGZNdBF_tWmOg7NDCK5PuGujNSG05sPdYINjGuo19g1Oc4c7V7fJhWB6Z3q88qth-SN2jPYas4zuZLseofeH-7e7x-L5Zfp0d_tcWCp4KuisbJyqK1lLVjLOSFlLU6tGUcspnTGhlK2kpNIxK5gyRJqmrMFWwGuVhx2hy43uKvjPwcWkR7duucyG_BC1KLlUOS2ayYt_yfxMyYQUGTz_Ay78EPr8C01pjjI7lSRTZEPZ4GMMrtGr0HYmrDUBPfalN33p3Jce-9Kj8tlWeZjl4H5vbAti3_Akj2c</recordid><startdate>200512</startdate><enddate>200512</enddate><creator>Sehirali, Salim</creator><creator>Inal, M Murat</creator><creator>Yildirim, Yusuf</creator><creator>Balim, Zuhal</creator><creator>Kosova, Buket</creator><creator>Karamizrak, Tulin</creator><creator>Sanci, Muzaffer</creator><creator>Topcuoglu, Nejat</creator><creator>Tinar, Sivekar</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>P64</scope></search><sort><creationdate>200512</creationdate><title>Prothrombin G20210A mutation in cases with recurrent miscarriage: a study of the mediterranean population</title><author>Sehirali, Salim ; Inal, M Murat ; Yildirim, Yusuf ; Balim, Zuhal ; Kosova, Buket ; Karamizrak, Tulin ; Sanci, Muzaffer ; Topcuoglu, Nejat ; Tinar, Sivekar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c274t-2b5fe9d68d83534315d8ad9f92c422b3799c68828e3c739a18af5d0c604d904d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Abortion, Habitual - genetics</topic><topic>Adult</topic><topic>Case-Control Studies</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Mediterranean Region</topic><topic>Mutation</topic><topic>Pregnancy</topic><topic>Prothrombin - genetics</topic><topic>Turkey - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sehirali, Salim</creatorcontrib><creatorcontrib>Inal, M Murat</creatorcontrib><creatorcontrib>Yildirim, Yusuf</creatorcontrib><creatorcontrib>Balim, Zuhal</creatorcontrib><creatorcontrib>Kosova, Buket</creatorcontrib><creatorcontrib>Karamizrak, Tulin</creatorcontrib><creatorcontrib>Sanci, Muzaffer</creatorcontrib><creatorcontrib>Topcuoglu, Nejat</creatorcontrib><creatorcontrib>Tinar, Sivekar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Archives of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sehirali, Salim</au><au>Inal, M Murat</au><au>Yildirim, Yusuf</au><au>Balim, Zuhal</au><au>Kosova, Buket</au><au>Karamizrak, Tulin</au><au>Sanci, Muzaffer</au><au>Topcuoglu, Nejat</au><au>Tinar, Sivekar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prothrombin G20210A mutation in cases with recurrent miscarriage: a study of the mediterranean population</atitle><jtitle>Archives of gynecology and obstetrics</jtitle><addtitle>Arch Gynecol Obstet</addtitle><date>2005-12</date><risdate>2005</risdate><volume>273</volume><issue>3</issue><spage>170</spage><epage>173</epage><pages>170-173</pages><issn>0932-0067</issn><eissn>1432-0711</eissn><abstract>Thrombophilic predisposition may be one of the underlying causes of recurrent miscariage (RM). The purpose of this study was to evaluate the Prothrombin G20210A mutation in cases with history of RM.
A total of 104 cases, 55 with diagnosis of RM and 49 control cases, were included in this controlled study. In all cases, in addition to full examination tests, Prothrombin 20210A mutation analysis was carried out by means of Polymerase Chain Reaction (PCR).
Mean number of the abortion was 3.51 +/- 0.74 in the RM group and 0.08 +/- 0.27 in the control group (p < 0.05). As a consequence of comprehensive examinations, in 24 (43.6%) of 55 RM cases at least one etiologic factor was put forth. Prothrombin G20210A mutation was observed in six (10.9%) cases of the RM group and one (2.04%) in the control group (p < 0.05). Four of the six cases (66.7%) of Prothrombin G20210A mutation had a subsequent pregnancy. Among these four pregnancies, there was one spontaneous loss at 14 weeks of gestation and one severe pre-eclampsia.
Our data together with literature suggest that Prothrombin G20210A mutation may be associated with RM. We recommend this genetic testing as a screening tool for women with history of RM.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>16189694</pmid><doi>10.1007/s00404-005-0061-7</doi><tpages>4</tpages></addata></record> |
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| ispartof | Archives of gynecology and obstetrics, 2005-12, Vol.273 (3), p.170-173 |
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| subjects | Abortion, Habitual - genetics Adult Case-Control Studies European Continental Ancestry Group - genetics Female Genetic Predisposition to Disease Humans Mediterranean Region Mutation Pregnancy Prothrombin - genetics Turkey - epidemiology |
| title | Prothrombin G20210A mutation in cases with recurrent miscarriage: a study of the mediterranean population |
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