The effect of carnosine treatment on prooxidant–antioxidant balance in liver, heart and brain tissues of male aged rats
Carnosine (β-alanyl- l -histidine) is a dipeptide with antioxidant properties. Oxidative damage by free radicals is one of the mechanisms underlying the aging process. This study was done to investigate the effects of carnosine treatment on lipid peroxidation and antioxidant status of liver, heart,...
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| Veröffentlicht in: | Biogerontology (Dordrecht) 2010-02, Vol.11 (1), p.103-109 |
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| creator | Aydın, A. F. Küçükgergin, C. Özdemirler-Erata, G. Koçak-Toker, N. Uysal, M. |
| description | Carnosine (β-alanyl-
l
-histidine) is a dipeptide with antioxidant properties. Oxidative damage by free radicals is one of the mechanisms underlying the aging process. This study was done to investigate the effects of carnosine treatment on lipid peroxidation and antioxidant status of liver, heart, brain in male young and aged rats. At the initiation of study, young and aged rats were 5 and 22 months old, respectively. Carnosine (250 mg/kg, daily, i.p.) was administered for 1 month to rats. At the end of this period, malondialdehyde (MDA) and diene conjugate (DC) and protein carbonyl (PC) levels, glutathione (GSH), vitamin E and vitamin C levels and Cu,Zn-superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione transferase (GST) activities were determined in tissues of carnosine-treated young and old rats. Liver and heart, but not brain MDA and DC levels increased significantly in aged rats as compared to young rats. Liver PC levels were also significantly elevated. Significant decreases in GSH and vitamin C levels and SOD activities were detected in liver of aged rats, but vitamin E levels and GSH-Px and GST activities remained unchanged. Non-enzymatic and enzymatic antioxidants did not change in heart and brain of aged rats. Carnosine treatment decreased high MDA, DC and PC levels and caused significant increases in vitamin E level and SOD activity in the liver of aged rats. There were no changes in non-enzymatic and enzymatic antioxidants in the heart and brain of carnosine-treated aged rats. In conclusion, carnosine treatment was found to be useful in the decrease of age-related oxidative stress in the liver. |
| doi_str_mv | 10.1007/s10522-009-9232-4 |
| format | Article |
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l
-histidine) is a dipeptide with antioxidant properties. Oxidative damage by free radicals is one of the mechanisms underlying the aging process. This study was done to investigate the effects of carnosine treatment on lipid peroxidation and antioxidant status of liver, heart, brain in male young and aged rats. At the initiation of study, young and aged rats were 5 and 22 months old, respectively. Carnosine (250 mg/kg, daily, i.p.) was administered for 1 month to rats. At the end of this period, malondialdehyde (MDA) and diene conjugate (DC) and protein carbonyl (PC) levels, glutathione (GSH), vitamin E and vitamin C levels and Cu,Zn-superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione transferase (GST) activities were determined in tissues of carnosine-treated young and old rats. Liver and heart, but not brain MDA and DC levels increased significantly in aged rats as compared to young rats. Liver PC levels were also significantly elevated. Significant decreases in GSH and vitamin C levels and SOD activities were detected in liver of aged rats, but vitamin E levels and GSH-Px and GST activities remained unchanged. Non-enzymatic and enzymatic antioxidants did not change in heart and brain of aged rats. Carnosine treatment decreased high MDA, DC and PC levels and caused significant increases in vitamin E level and SOD activity in the liver of aged rats. There were no changes in non-enzymatic and enzymatic antioxidants in the heart and brain of carnosine-treated aged rats. In conclusion, carnosine treatment was found to be useful in the decrease of age-related oxidative stress in the liver.</description><identifier>ISSN: 1389-5729</identifier><identifier>EISSN: 1573-6768</identifier><identifier>DOI: 10.1007/s10522-009-9232-4</identifier><identifier>PMID: 19430956</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Aging ; Aging - drug effects ; Aging - metabolism ; Alzheimer's disease ; Animals ; Antioxidants ; Antioxidants - metabolism ; Biological and medical sciences ; Biomedical and Life Sciences ; Brain - drug effects ; Brain - metabolism ; Brain research ; Carnosine - administration & dosage ; Cell Biology ; Development. Metamorphosis. Moult. Ageing ; Developmental Biology ; Free radicals ; Fundamental and applied biological sciences. Psychology ; Geriatrics/Gerontology ; Heart - drug effects ; Homeostasis - drug effects ; Homeostasis - physiology ; Life Sciences ; Lipid peroxidation ; Lipids ; Liver ; Liver - drug effects ; Liver - metabolism ; Male ; Myocardium - metabolism ; Oxidative stress ; Oxidative Stress - drug effects ; Oxidative Stress - physiology ; Proteins ; Rats ; Rats, Wistar ; Reactive Oxygen Species - metabolism ; Research Article ; Senescence ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin C ; Vitamin E</subject><ispartof>Biogerontology (Dordrecht), 2010-02, Vol.11 (1), p.103-109</ispartof><rights>Springer Science+Business Media B.V. 2009</rights><rights>2015 INIST-CNRS</rights><rights>Springer Science+Business Media B.V. 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-7002ed92a1f973a03db5ff5e46718ad2b49eb183065d94ef267638245320b1ab3</citedby><cites>FETCH-LOGICAL-c498t-7002ed92a1f973a03db5ff5e46718ad2b49eb183065d94ef267638245320b1ab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10522-009-9232-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10522-009-9232-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22275302$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19430956$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aydın, A. F.</creatorcontrib><creatorcontrib>Küçükgergin, C.</creatorcontrib><creatorcontrib>Özdemirler-Erata, G.</creatorcontrib><creatorcontrib>Koçak-Toker, N.</creatorcontrib><creatorcontrib>Uysal, M.</creatorcontrib><title>The effect of carnosine treatment on prooxidant–antioxidant balance in liver, heart and brain tissues of male aged rats</title><title>Biogerontology (Dordrecht)</title><addtitle>Biogerontology</addtitle><addtitle>Biogerontology</addtitle><description>Carnosine (β-alanyl-
l
-histidine) is a dipeptide with antioxidant properties. Oxidative damage by free radicals is one of the mechanisms underlying the aging process. This study was done to investigate the effects of carnosine treatment on lipid peroxidation and antioxidant status of liver, heart, brain in male young and aged rats. At the initiation of study, young and aged rats were 5 and 22 months old, respectively. Carnosine (250 mg/kg, daily, i.p.) was administered for 1 month to rats. At the end of this period, malondialdehyde (MDA) and diene conjugate (DC) and protein carbonyl (PC) levels, glutathione (GSH), vitamin E and vitamin C levels and Cu,Zn-superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione transferase (GST) activities were determined in tissues of carnosine-treated young and old rats. Liver and heart, but not brain MDA and DC levels increased significantly in aged rats as compared to young rats. Liver PC levels were also significantly elevated. Significant decreases in GSH and vitamin C levels and SOD activities were detected in liver of aged rats, but vitamin E levels and GSH-Px and GST activities remained unchanged. Non-enzymatic and enzymatic antioxidants did not change in heart and brain of aged rats. Carnosine treatment decreased high MDA, DC and PC levels and caused significant increases in vitamin E level and SOD activity in the liver of aged rats. There were no changes in non-enzymatic and enzymatic antioxidants in the heart and brain of carnosine-treated aged rats. In conclusion, carnosine treatment was found to be useful in the decrease of age-related oxidative stress in the liver.</description><subject>Aging</subject><subject>Aging - drug effects</subject><subject>Aging - metabolism</subject><subject>Alzheimer's disease</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Brain research</subject><subject>Carnosine - administration & dosage</subject><subject>Cell Biology</subject><subject>Development. Metamorphosis. Moult. Ageing</subject><subject>Developmental Biology</subject><subject>Free radicals</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Geriatrics/Gerontology</subject><subject>Heart - drug effects</subject><subject>Homeostasis - drug effects</subject><subject>Homeostasis - physiology</subject><subject>Life Sciences</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Myocardium - metabolism</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxidative Stress - physiology</subject><subject>Proteins</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Research Article</subject><subject>Senescence</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vitamin C</subject><subject>Vitamin E</subject><issn>1389-5729</issn><issn>1573-6768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkcuKFTEQhoMozkUfwI0EQdzYWrl1kqUMOgoDbsZ1qO6uzPTQnR6TPuLsfAff0Ccxh9M4IIibJFX5qvJXfsaeCXgjAOzbIsBI2QD4xkslG_2AHQtjVdPa1j2sZ-V8Y6z0R-yklBsA0crWPGZHwmsF3rTH7O7ymjjFSP3Kl8h7zGkpYyK-ZsJ1plTTid_mZfk-DpjWXz9-1nXcIt7hhKknPiY-jd8ov-bXhHnlmAbeZazpdSxlR2XffMaJOF7RwDOu5Ql7FHEq9HTbT9mXD-8vzz42F5_PP529u2h67d3aWABJg5coorcKQQ2didGQbq1wOMhOe-qEU9CawWuKss6unNRGSegEduqUvTr0rUN8rUrWMI-lp6kKp2VXgjXaeTBe_Z9UqnVWA1TyxV_kzbLLqY4RpDDOOTCmQuIA9XkpJVMMt3mcMd8FAWHvXzj4F6p_Ye9f0LXm-dZ418003FdshlXg5QZg6XGKuX7_WP5wUkprFMjKyQNX6lW6onyv8N-v_wYiILMA</recordid><startdate>20100201</startdate><enddate>20100201</enddate><creator>Aydın, A. 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Psychology</topic><topic>Geriatrics/Gerontology</topic><topic>Heart - drug effects</topic><topic>Homeostasis - drug effects</topic><topic>Homeostasis - physiology</topic><topic>Life Sciences</topic><topic>Lipid peroxidation</topic><topic>Lipids</topic><topic>Liver</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Myocardium - metabolism</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Oxidative Stress - physiology</topic><topic>Proteins</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Research Article</topic><topic>Senescence</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vitamin C</topic><topic>Vitamin E</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aydın, A. F.</creatorcontrib><creatorcontrib>Küçükgergin, C.</creatorcontrib><creatorcontrib>Özdemirler-Erata, G.</creatorcontrib><creatorcontrib>Koçak-Toker, N.</creatorcontrib><creatorcontrib>Uysal, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Social Science Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Biogerontology (Dordrecht)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aydın, A. F.</au><au>Küçükgergin, C.</au><au>Özdemirler-Erata, G.</au><au>Koçak-Toker, N.</au><au>Uysal, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of carnosine treatment on prooxidant–antioxidant balance in liver, heart and brain tissues of male aged rats</atitle><jtitle>Biogerontology (Dordrecht)</jtitle><stitle>Biogerontology</stitle><addtitle>Biogerontology</addtitle><date>2010-02-01</date><risdate>2010</risdate><volume>11</volume><issue>1</issue><spage>103</spage><epage>109</epage><pages>103-109</pages><issn>1389-5729</issn><eissn>1573-6768</eissn><abstract>Carnosine (β-alanyl-
l
-histidine) is a dipeptide with antioxidant properties. Oxidative damage by free radicals is one of the mechanisms underlying the aging process. This study was done to investigate the effects of carnosine treatment on lipid peroxidation and antioxidant status of liver, heart, brain in male young and aged rats. At the initiation of study, young and aged rats were 5 and 22 months old, respectively. Carnosine (250 mg/kg, daily, i.p.) was administered for 1 month to rats. At the end of this period, malondialdehyde (MDA) and diene conjugate (DC) and protein carbonyl (PC) levels, glutathione (GSH), vitamin E and vitamin C levels and Cu,Zn-superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione transferase (GST) activities were determined in tissues of carnosine-treated young and old rats. Liver and heart, but not brain MDA and DC levels increased significantly in aged rats as compared to young rats. Liver PC levels were also significantly elevated. Significant decreases in GSH and vitamin C levels and SOD activities were detected in liver of aged rats, but vitamin E levels and GSH-Px and GST activities remained unchanged. Non-enzymatic and enzymatic antioxidants did not change in heart and brain of aged rats. Carnosine treatment decreased high MDA, DC and PC levels and caused significant increases in vitamin E level and SOD activity in the liver of aged rats. There were no changes in non-enzymatic and enzymatic antioxidants in the heart and brain of carnosine-treated aged rats. In conclusion, carnosine treatment was found to be useful in the decrease of age-related oxidative stress in the liver.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>19430956</pmid><doi>10.1007/s10522-009-9232-4</doi><tpages>7</tpages></addata></record> |
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| subjects | Aging Aging - drug effects Aging - metabolism Alzheimer's disease Animals Antioxidants Antioxidants - metabolism Biological and medical sciences Biomedical and Life Sciences Brain - drug effects Brain - metabolism Brain research Carnosine - administration & dosage Cell Biology Development. Metamorphosis. Moult. Ageing Developmental Biology Free radicals Fundamental and applied biological sciences. Psychology Geriatrics/Gerontology Heart - drug effects Homeostasis - drug effects Homeostasis - physiology Life Sciences Lipid peroxidation Lipids Liver Liver - drug effects Liver - metabolism Male Myocardium - metabolism Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Proteins Rats Rats, Wistar Reactive Oxygen Species - metabolism Research Article Senescence Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin C Vitamin E |
| title | The effect of carnosine treatment on prooxidant–antioxidant balance in liver, heart and brain tissues of male aged rats |
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