Interstitial continuous infusion therapy in a malignant glioma model in rats
Purpose Local direct delivery of chemotherapeutic agents for the treatment of brain tumors is an area of focus in the development of new therapeutic paradigms. These techniques need improvement, especially in terms of drug retention in brain tissue. Materials and methods In this study, we used a rat...
Gespeichert in:
| Veröffentlicht in: | Child's nervous system 2009-06, Vol.25 (6), p.655-662 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 662 |
|---|---|
| container_issue | 6 |
| container_start_page | 655 |
| container_title | Child's nervous system |
| container_volume | 25 |
| creator | Tange, Yuichi Kondo, Akihide Egorin, Merrill J. Mania-Farnell, Barbara Daneriallis, Georgy M. Nakazaki, Hiromichi Sredni, Simone T. Rajaram, Veena Goldman, Stewart Soares, Marcelo B. Tomita, Tadanori |
| description | Purpose
Local direct delivery of chemotherapeutic agents for the treatment of brain tumors is an area of focus in the development of new therapeutic paradigms. These techniques need improvement, especially in terms of drug retention in brain tissue.
Materials and methods
In this study, we used a rat glioma model to examine carboplatin distribution, as measured by platinum penetration, after delivery via interstitial continuous (i.c.) infusion. We also examined rat survival times in response to carboplatin and oxaliplatin. I.C. infusion, a modified version of convection-enhanced delivery (CED) for local drug delivery, uses low volume (1 μl per hour) continuous infusion directly into the tumor.
Results
I.C. infusion produced a nearly 360-fold higher concentration of platinum in tumor tissue and significantly prolonged rodent survival time compared to intraperitoneal (i.p.) infusion.
Conclusions
We showed i.c. infusion allows for circumvention of the blood–brain barrier, focused drug distribution, and sustained drug delivery. This method could be a promising strategy for treating brain tumors. |
| doi_str_mv | 10.1007/s00381-008-0805-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_754890518</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>754890518</sourcerecordid><originalsourceid>FETCH-LOGICAL-c374t-57d7dd452978f484502681abd7138d1f685184b1174d3bbc29461498d344d6e03</originalsourceid><addsrcrecordid>eNp9kD9PwzAQxS0EoqXwAVhQNqbAObZjZ0SIP5UqscBsObFTXCV2sZ2h3x5XqcTGdNK7957ufgjdYnjAAPwxAhCBSwBRggBWkjO0xJSQEgiDc7SEitUlBwoLdBXjDgAzUTWXaIGbClec0yXarF0yISabrBqKzrtk3eSnWFjXT9F6V6RvE9T-kIVCFaMa7NYpl4rtYP2YBa_NcNwFleI1uujVEM3Naa7Q1-vL5_N7ufl4Wz8_bcqOcJpKxjXXmrKq4aKngjKoaoFVqzkmQuO-FgwL2mLMqSZt21UNrTFthCaU6toAWaH7uXcf_M9kYpKjjZ0ZBuVMvl1yRkUDuSQ78ezsgo8xmF7ugx1VOEgM8shQzgxlZiiPDCXJmbtT-9SORv8lTtCyoZoNMa_c1gS581Nw-eN_Wn8BlJF7Xw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>754890518</pqid></control><display><type>article</type><title>Interstitial continuous infusion therapy in a malignant glioma model in rats</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Tange, Yuichi ; Kondo, Akihide ; Egorin, Merrill J. ; Mania-Farnell, Barbara ; Daneriallis, Georgy M. ; Nakazaki, Hiromichi ; Sredni, Simone T. ; Rajaram, Veena ; Goldman, Stewart ; Soares, Marcelo B. ; Tomita, Tadanori</creator><creatorcontrib>Tange, Yuichi ; Kondo, Akihide ; Egorin, Merrill J. ; Mania-Farnell, Barbara ; Daneriallis, Georgy M. ; Nakazaki, Hiromichi ; Sredni, Simone T. ; Rajaram, Veena ; Goldman, Stewart ; Soares, Marcelo B. ; Tomita, Tadanori</creatorcontrib><description>Purpose
Local direct delivery of chemotherapeutic agents for the treatment of brain tumors is an area of focus in the development of new therapeutic paradigms. These techniques need improvement, especially in terms of drug retention in brain tissue.
Materials and methods
In this study, we used a rat glioma model to examine carboplatin distribution, as measured by platinum penetration, after delivery via interstitial continuous (i.c.) infusion. We also examined rat survival times in response to carboplatin and oxaliplatin. I.C. infusion, a modified version of convection-enhanced delivery (CED) for local drug delivery, uses low volume (1 μl per hour) continuous infusion directly into the tumor.
Results
I.C. infusion produced a nearly 360-fold higher concentration of platinum in tumor tissue and significantly prolonged rodent survival time compared to intraperitoneal (i.p.) infusion.
Conclusions
We showed i.c. infusion allows for circumvention of the blood–brain barrier, focused drug distribution, and sustained drug delivery. This method could be a promising strategy for treating brain tumors.</description><identifier>ISSN: 0256-7040</identifier><identifier>EISSN: 1433-0350</identifier><identifier>DOI: 10.1007/s00381-008-0805-3</identifier><identifier>PMID: 19212774</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Animals ; Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - pharmacokinetics ; Blood-Brain Barrier - drug effects ; Brain - drug effects ; Brain - metabolism ; Brain - pathology ; Brain Neoplasms - drug therapy ; Brain Neoplasms - mortality ; Brain Neoplasms - pathology ; Carboplatin - administration & dosage ; Carboplatin - pharmacokinetics ; Catheterization ; Cell Line, Tumor ; Corpus Striatum - drug effects ; Disease Models, Animal ; Glioma - drug therapy ; Glioma - mortality ; Glioma - pathology ; Kaplan-Meier Estimate ; Male ; Medicine ; Medicine & Public Health ; Neoplasm Transplantation ; Neurosciences ; Neurosurgery ; Organoplatinum Compounds - administration & dosage ; Organoplatinum Compounds - pharmacokinetics ; Original Paper ; Platinum - metabolism ; Rats ; Rats, Inbred F344 ; Treatment Outcome</subject><ispartof>Child's nervous system, 2009-06, Vol.25 (6), p.655-662</ispartof><rights>Springer-Verlag 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c374t-57d7dd452978f484502681abd7138d1f685184b1174d3bbc29461498d344d6e03</citedby><cites>FETCH-LOGICAL-c374t-57d7dd452978f484502681abd7138d1f685184b1174d3bbc29461498d344d6e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00381-008-0805-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00381-008-0805-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19212774$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tange, Yuichi</creatorcontrib><creatorcontrib>Kondo, Akihide</creatorcontrib><creatorcontrib>Egorin, Merrill J.</creatorcontrib><creatorcontrib>Mania-Farnell, Barbara</creatorcontrib><creatorcontrib>Daneriallis, Georgy M.</creatorcontrib><creatorcontrib>Nakazaki, Hiromichi</creatorcontrib><creatorcontrib>Sredni, Simone T.</creatorcontrib><creatorcontrib>Rajaram, Veena</creatorcontrib><creatorcontrib>Goldman, Stewart</creatorcontrib><creatorcontrib>Soares, Marcelo B.</creatorcontrib><creatorcontrib>Tomita, Tadanori</creatorcontrib><title>Interstitial continuous infusion therapy in a malignant glioma model in rats</title><title>Child's nervous system</title><addtitle>Childs Nerv Syst</addtitle><addtitle>Childs Nerv Syst</addtitle><description>Purpose
Local direct delivery of chemotherapeutic agents for the treatment of brain tumors is an area of focus in the development of new therapeutic paradigms. These techniques need improvement, especially in terms of drug retention in brain tissue.
Materials and methods
In this study, we used a rat glioma model to examine carboplatin distribution, as measured by platinum penetration, after delivery via interstitial continuous (i.c.) infusion. We also examined rat survival times in response to carboplatin and oxaliplatin. I.C. infusion, a modified version of convection-enhanced delivery (CED) for local drug delivery, uses low volume (1 μl per hour) continuous infusion directly into the tumor.
Results
I.C. infusion produced a nearly 360-fold higher concentration of platinum in tumor tissue and significantly prolonged rodent survival time compared to intraperitoneal (i.p.) infusion.
Conclusions
We showed i.c. infusion allows for circumvention of the blood–brain barrier, focused drug distribution, and sustained drug delivery. This method could be a promising strategy for treating brain tumors.</description><subject>Animals</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Antineoplastic Agents - pharmacokinetics</subject><subject>Blood-Brain Barrier - drug effects</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Brain Neoplasms - drug therapy</subject><subject>Brain Neoplasms - mortality</subject><subject>Brain Neoplasms - pathology</subject><subject>Carboplatin - administration & dosage</subject><subject>Carboplatin - pharmacokinetics</subject><subject>Catheterization</subject><subject>Cell Line, Tumor</subject><subject>Corpus Striatum - drug effects</subject><subject>Disease Models, Animal</subject><subject>Glioma - drug therapy</subject><subject>Glioma - mortality</subject><subject>Glioma - pathology</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neoplasm Transplantation</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Organoplatinum Compounds - administration & dosage</subject><subject>Organoplatinum Compounds - pharmacokinetics</subject><subject>Original Paper</subject><subject>Platinum - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Treatment Outcome</subject><issn>0256-7040</issn><issn>1433-0350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD9PwzAQxS0EoqXwAVhQNqbAObZjZ0SIP5UqscBsObFTXCV2sZ2h3x5XqcTGdNK7957ufgjdYnjAAPwxAhCBSwBRggBWkjO0xJSQEgiDc7SEitUlBwoLdBXjDgAzUTWXaIGbClec0yXarF0yISabrBqKzrtk3eSnWFjXT9F6V6RvE9T-kIVCFaMa7NYpl4rtYP2YBa_NcNwFleI1uujVEM3Naa7Q1-vL5_N7ufl4Wz8_bcqOcJpKxjXXmrKq4aKngjKoaoFVqzkmQuO-FgwL2mLMqSZt21UNrTFthCaU6toAWaH7uXcf_M9kYpKjjZ0ZBuVMvl1yRkUDuSQ78ezsgo8xmF7ugx1VOEgM8shQzgxlZiiPDCXJmbtT-9SORv8lTtCyoZoNMa_c1gS581Nw-eN_Wn8BlJF7Xw</recordid><startdate>20090601</startdate><enddate>20090601</enddate><creator>Tange, Yuichi</creator><creator>Kondo, Akihide</creator><creator>Egorin, Merrill J.</creator><creator>Mania-Farnell, Barbara</creator><creator>Daneriallis, Georgy M.</creator><creator>Nakazaki, Hiromichi</creator><creator>Sredni, Simone T.</creator><creator>Rajaram, Veena</creator><creator>Goldman, Stewart</creator><creator>Soares, Marcelo B.</creator><creator>Tomita, Tadanori</creator><general>Springer-Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>20090601</creationdate><title>Interstitial continuous infusion therapy in a malignant glioma model in rats</title><author>Tange, Yuichi ; Kondo, Akihide ; Egorin, Merrill J. ; Mania-Farnell, Barbara ; Daneriallis, Georgy M. ; Nakazaki, Hiromichi ; Sredni, Simone T. ; Rajaram, Veena ; Goldman, Stewart ; Soares, Marcelo B. ; Tomita, Tadanori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-57d7dd452978f484502681abd7138d1f685184b1174d3bbc29461498d344d6e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Antineoplastic Agents - pharmacokinetics</topic><topic>Blood-Brain Barrier - drug effects</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Brain Neoplasms - drug therapy</topic><topic>Brain Neoplasms - mortality</topic><topic>Brain Neoplasms - pathology</topic><topic>Carboplatin - administration & dosage</topic><topic>Carboplatin - pharmacokinetics</topic><topic>Catheterization</topic><topic>Cell Line, Tumor</topic><topic>Corpus Striatum - drug effects</topic><topic>Disease Models, Animal</topic><topic>Glioma - drug therapy</topic><topic>Glioma - mortality</topic><topic>Glioma - pathology</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neoplasm Transplantation</topic><topic>Neurosciences</topic><topic>Neurosurgery</topic><topic>Organoplatinum Compounds - administration & dosage</topic><topic>Organoplatinum Compounds - pharmacokinetics</topic><topic>Original Paper</topic><topic>Platinum - metabolism</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tange, Yuichi</creatorcontrib><creatorcontrib>Kondo, Akihide</creatorcontrib><creatorcontrib>Egorin, Merrill J.</creatorcontrib><creatorcontrib>Mania-Farnell, Barbara</creatorcontrib><creatorcontrib>Daneriallis, Georgy M.</creatorcontrib><creatorcontrib>Nakazaki, Hiromichi</creatorcontrib><creatorcontrib>Sredni, Simone T.</creatorcontrib><creatorcontrib>Rajaram, Veena</creatorcontrib><creatorcontrib>Goldman, Stewart</creatorcontrib><creatorcontrib>Soares, Marcelo B.</creatorcontrib><creatorcontrib>Tomita, Tadanori</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Child's nervous system</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tange, Yuichi</au><au>Kondo, Akihide</au><au>Egorin, Merrill J.</au><au>Mania-Farnell, Barbara</au><au>Daneriallis, Georgy M.</au><au>Nakazaki, Hiromichi</au><au>Sredni, Simone T.</au><au>Rajaram, Veena</au><au>Goldman, Stewart</au><au>Soares, Marcelo B.</au><au>Tomita, Tadanori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interstitial continuous infusion therapy in a malignant glioma model in rats</atitle><jtitle>Child's nervous system</jtitle><stitle>Childs Nerv Syst</stitle><addtitle>Childs Nerv Syst</addtitle><date>2009-06-01</date><risdate>2009</risdate><volume>25</volume><issue>6</issue><spage>655</spage><epage>662</epage><pages>655-662</pages><issn>0256-7040</issn><eissn>1433-0350</eissn><abstract>Purpose
Local direct delivery of chemotherapeutic agents for the treatment of brain tumors is an area of focus in the development of new therapeutic paradigms. These techniques need improvement, especially in terms of drug retention in brain tissue.
Materials and methods
In this study, we used a rat glioma model to examine carboplatin distribution, as measured by platinum penetration, after delivery via interstitial continuous (i.c.) infusion. We also examined rat survival times in response to carboplatin and oxaliplatin. I.C. infusion, a modified version of convection-enhanced delivery (CED) for local drug delivery, uses low volume (1 μl per hour) continuous infusion directly into the tumor.
Results
I.C. infusion produced a nearly 360-fold higher concentration of platinum in tumor tissue and significantly prolonged rodent survival time compared to intraperitoneal (i.p.) infusion.
Conclusions
We showed i.c. infusion allows for circumvention of the blood–brain barrier, focused drug distribution, and sustained drug delivery. This method could be a promising strategy for treating brain tumors.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>19212774</pmid><doi>10.1007/s00381-008-0805-3</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0256-7040 |
| ispartof | Child's nervous system, 2009-06, Vol.25 (6), p.655-662 |
| issn | 0256-7040 1433-0350 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_754890518 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics Blood-Brain Barrier - drug effects Brain - drug effects Brain - metabolism Brain - pathology Brain Neoplasms - drug therapy Brain Neoplasms - mortality Brain Neoplasms - pathology Carboplatin - administration & dosage Carboplatin - pharmacokinetics Catheterization Cell Line, Tumor Corpus Striatum - drug effects Disease Models, Animal Glioma - drug therapy Glioma - mortality Glioma - pathology Kaplan-Meier Estimate Male Medicine Medicine & Public Health Neoplasm Transplantation Neurosciences Neurosurgery Organoplatinum Compounds - administration & dosage Organoplatinum Compounds - pharmacokinetics Original Paper Platinum - metabolism Rats Rats, Inbred F344 Treatment Outcome |
| title | Interstitial continuous infusion therapy in a malignant glioma model in rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T02%3A01%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Interstitial%20continuous%20infusion%20therapy%20in%20a%20malignant%20glioma%20model%20in%20rats&rft.jtitle=Child's%20nervous%20system&rft.au=Tange,%20Yuichi&rft.date=2009-06-01&rft.volume=25&rft.issue=6&rft.spage=655&rft.epage=662&rft.pages=655-662&rft.issn=0256-7040&rft.eissn=1433-0350&rft_id=info:doi/10.1007/s00381-008-0805-3&rft_dat=%3Cproquest_cross%3E754890518%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=754890518&rft_id=info:pmid/19212774&rfr_iscdi=true |