Ginsenoside Rb1 and Rg3 Attenuate Glucocorticoid-Induced Neurotoxicity

Glucocorticoid (GC) hormones, increased in response to stress, can cause neuronal loss. We tested the effect of GC hormone on cell viability of neural SHSY-5Y cells and protective effects of ginsenoside Rb1 and Rg3 on the action of GC. We treated SHSY-5Y cells with increasing concentrations of synth...

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Veröffentlicht in:	Cellular and molecular neurobiology 2010-08, Vol.30 (6), p.857-862
Hauptverfasser:	Kim, Sung-Ok, You, Jung-Man, Yun, Su-Jin, Son, Min-Sook, Nam, Kyong Nyon, Hong, Joung-Woo, Kim, Sun Yeou, Choi, Sang Yoon, Lee, Eunjoo H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Biomedical and Life Sciences Biomedicine Cell Biology Cell Line, Tumor Cell Survival - drug effects dexamethasone Dexamethasone - toxicity Gene Expression Regulation - drug effects Ginsenoside Ginsenosides - pharmacology Glucocorticoid Glucocorticoids - toxicity Hippocampus - drug effects Hippocampus - pathology Humans Male Neurobiology Neuroprotection Neurosciences neurotoxicity Neurotoxins - toxicity Organotypic hippocampal slice culture Original Research Rats Rats, Sprague-Dawley reactive oxygen species Reactive Oxygen Species - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism SHSY-5Y Stress
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