Losartan improved respiratory function and coenzyme Q content in brain mitochondria of young spontaneously hypertensive rats

Increased production of free radicals and impairment of mitochondrial function are important factors in the pathogenesis of hypertension. This study examined the impact of hypertension on mitochondrial respiratory chain function, coenzyme Q₉ (CoQ₉), coenzyme Q₁₀ (CoQ₁₀), and α-tocopherol content in...

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Veröffentlicht in:	Cellular and molecular neurobiology 2010-07, Vol.30 (5), p.751-758
Hauptverfasser:	Sumbalová, Z, Kucharská, J, Kristek, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - drug effects alpha-Tocopherol - metabolism Angiotensin II Type 1 Receptor Blockers - pharmacology Animals Antioxidants - metabolism Biomedical and Life Sciences Biomedicine Brain - drug effects Brain - metabolism Brain mitochondria Cell Biology Cell Respiration - drug effects Electron Transport - drug effects Electron Transport Complex IV - metabolism Geometry of basilar artery Glutamates - metabolism hypertension Losartan Losartan - pharmacology Mitochondria - drug effects Mitochondria - metabolism Neurobiology Neurosciences Original Research Rats Rats, Inbred SHR Rats, Wistar Respiration Rotenone - pharmacology Spontaneously hypertensive rats Succinic Acid - metabolism Ubiquinone - analogs & derivatives Ubiquinone - metabolism ubiquinones α-tocopherol
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