Notch1-induced mammary tumor development is cyclin D1-dependent and correlates with expansion of pre-malignant multipotent duct-limited progenitors

Members of the Notch family are involved in the development of breast cancer in animal models and in humans. In young transgenic mice, expressing intracellular activated Notch1 (N1 IC ) in mammary cells, we found that CD24 + CD29 high progenitor cells had enhanced survival, and were expanded through...

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Veröffentlicht in:	Oncogene 2010-08, Vol.29 (32), p.4543-4554
Hauptverfasser:	Ling, H, Sylvestre, J-R, Jolicoeur, P
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1347 631/67/71 631/80/86 Animal models Animals Apoptosis Basal cells Breast cancer c-Myc protein CD24 Antigen - metabolism Cell Biology Cell Culture Techniques Cell Differentiation Cell Proliferation Cell self-renewal Cell Transformation, Neoplastic Cellular biology Cyclin D1 Cyclin D1 - deficiency Cyclin D1 - metabolism Cyclins Female Gene Expression Regulation, Neoplastic Genetic aspects Genetic transformation Genetics Health aspects Human Genetics Integrin beta1 - metabolism Internal Medicine Malignancy Mammary gland Mammary Glands, Animal - growth & development Mammary Glands, Animal - pathology Mammary Neoplasms, Experimental - genetics Mammary Neoplasms, Experimental - metabolism Mammary Neoplasms, Experimental - pathology Mammary Tumor Virus, Mouse - genetics Medicine Medicine & Public Health Mice Mice, Transgenic Multipotent Stem Cells - metabolism Multipotent Stem Cells - pathology Myc protein Notch1 protein Oncology original-article Physiological aspects Progenitor cells PTEN Phosphohydrolase - genetics PTEN protein Receptor, Notch1 - genetics Receptor, Notch1 - metabolism Risk factors Stem cell transplantation Stem cells Transgenic animals Transgenic mice Tumor Suppressor Protein p53 - genetics Tumors
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