Molecular Analysis of Endoplasmic Reticulum Stress Response After Global Forebrain Ischemia/Reperfusion in Rats: Effect of Neuroprotectant Simvastatin

Simvastatin is a cholesterol-lowering agent whose functional significance and neuroprotective mechanism in ischemic brain injury is not yet solved. The purpose of this study is to evaluate the effect of simvastatin on ischemic brain injury. We examined the endoplasmic reticulum stress response (UPR/...

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Veröffentlicht in:	Cellular and molecular neurobiology 2009-03, Vol.29 (2), p.181-192
Hauptverfasser:	Urban, P, Pavlíková, M, Sivonová, M, Kaplán, P, Tatarková, Z, Kaminska, B, Lehotský, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 6 - drug effects Activating Transcription Factor 6 - genetics Activating Transcription Factor 6 - metabolism Animals Biomedical and Life Sciences Biomedicine Cell Biology DNA-Binding Proteins - drug effects DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - genetics Endoplasmic Reticulum - metabolism Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Heat-Shock Proteins - drug effects Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Hypoxia-Ischemia, Brain - drug therapy Hypoxia-Ischemia, Brain - genetics Hypoxia-Ischemia, Brain - metabolism Male Molecular Chaperones - drug effects Molecular Chaperones - genetics Molecular Chaperones - metabolism Neurobiology Neuroprotective Agents - pharmacology Neurosciences Original Paper Oxidative Stress - drug effects Oxidative Stress - physiology Protein Folding - drug effects Rats Rats, Wistar Regulatory Factor X Transcription Factors Reperfusion Injury - drug therapy Reperfusion Injury - genetics Reperfusion Injury - metabolism RNA, Messenger - drug effects RNA, Messenger - metabolism Simvastatin - pharmacology Time Factors Transcription Factors - drug effects Transcription Factors - genetics Transcription Factors - metabolism Up-Regulation - drug effects Up-Regulation - physiology X-Box Binding Protein 1
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