A high-density SNP genome-wide linkage scan in a large autism extended pedigree

We performed a high-density, single nucleotide polymorphism (SNP), genome-wide scan on a six-generation pedigree from Utah with seven affected males, diagnosed with autism spectrum disorder. Using a two-stage linkage design, we first performed a nonparametric analysis on the entire genome using a 10...

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Veröffentlicht in:	Molecular psychiatry 2009-06, Vol.14 (6), p.590-600
Hauptverfasser:	Allen-Brady, K, Miller, J, Matsunami, N, Stevens, J, Block, H, Farley, M, Krasny, L, Pingree, C, Lainhart, J, Leppert, M, McMahon, W M, Coon, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Autism Autistic Disorder - genetics Behavioral Sciences Biological and medical sciences Biological Psychology Child Child clinical studies Chromosome abnormalities Complications and side effects Developmental disorders Diagnosis Disease susceptibility Drosophila Proteins Family Health Female Follow-Up Studies Gene polymorphism Genetic aspects Genomes Genomics Haplotypes Humans Infantile autism Linkage Disequilibrium Male Medical sciences Medicine Medicine & Public Health Membrane Proteins Middle Aged Neurosciences original-article Pedigree Pharmacotherapy Phenotype Phenotypes Polymorphism, Single Nucleotide Principal components analysis Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Risk factors Single nucleotide polymorphisms Single-nucleotide polymorphism
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