Antigen-Binding Diversity of Human Hybridoma Autoantibodies Derived from Splenocytes of Patients with SLE

The antigen-binding specificity of human hybridoma-derived monoclonal autoantibodies (mAb) was analysed with mAbs derived from the spleens of two patients with active systemic lupus erythematosus (SLE). From one patient 72 mAbs (RSP clones) and from the other 173 mAbs (RT clones) were obtained. The...

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Veröffentlicht in:	Lupus 1992-05, Vol.1 (3), p.157-165
Hauptverfasser:	Ravirajan, C.T., Kalsi, J., Winska Wiloch, H., Barakat, S., Tuaillon, N., Irvine, W., Cockayne, A., Harris, A., Williams, D.G., Williams, W., Axford, J., Muller, S., Isenberg, D.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antibodies, Anticardiolipin - metabolism Antibodies, Antinuclear - metabolism Antibodies, Monoclonal Antibody Affinity Antibody Diversity Antibody Specificity Autoantibodies - metabolism Autoantigens Female Humans Hybridomas - immunology Immunoglobulin G - metabolism Immunoglobulin M - metabolism Klebsiella Lupus Erythematosus, Systemic - immunology Salmonella typhimurium Spleen - immunology
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