Taurine reduces FK506-induced generation of ROS and activation of JNK and Bax in Madin Darby canine kidney cells

The immunosuppressive compound FK506 has been successfully used in kidney and liver transplant recipients. However, the compound can induce significant side effects on kidney function. Taurine is a potent free radical scavenger that attenuates a variety of renal diseases that are the consequence of...

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Veröffentlicht in:	Human & experimental toxicology 2010-08, Vol.29 (8), p.627-633
Hauptverfasser:	Jeon, Seol-Hee, Park, Hye-Min, Kim, Shang-Jin, Lee, Mun-Young, Kim, Gi-Beum, Mizanur Rahman, Md, Woo, Jeong-Nam, Kim, In-Shik, Kim, Jin-Shang, Kang, Hyung-Sub
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Antioxidants - pharmacology Apoptosis bcl-2-Associated X Protein - metabolism Biological and medical sciences Calcium - metabolism Cell Line Cell Survival - drug effects Dogs Drug toxicity and drugs side effects treatment Free radicals Immunosuppressive Agents - toxicity JNK Mitogen-Activated Protein Kinases - metabolism Kidney - drug effects Kidney - enzymology Kidney - metabolism Kidneys Magnesium - metabolism Medical sciences Oxidative Stress - drug effects Pharmacology. Drug treatments Proto-Oncogene Proteins c-bcl-2 - metabolism Reactive Oxygen Species - metabolism Tacrolimus - toxicity Taurine - pharmacology Toxicity: urogenital system Toxicology
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