Serum Apolipoprotein H Levels in Systemic Lupus Erythematosus Are Not Influenced by Antiphospholipid Antibodies
Anticardiolipin antibodies (aCL) were recently discovered to recognize a complex consisting of phospholipids and apolipoprotein H (apo H). In this study, we determined the serum apo H levels in 36 systemic lupus erythematosus (SLE) patients with or without antiphospholipid antibodies (aPL), includin...
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| Veröffentlicht in: | Lupus 1992-05, Vol.1 (3), p.145-149 |
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| creator | Ichikawa, Yukinobu Takamatsu, Kazunaga Shimizu, Hiroaki Uchiyama, Mitsuaki Moriuchi, Junko Takaya, Masatoshi Kobayashi, Nobumasa Kawada, Tsutomu Arimori, Shigeru |
| description | Anticardiolipin antibodies (aCL) were recently discovered to recognize a complex consisting of phospholipids and apolipoprotein H (apo H). In this study, we determined the serum apo H levels in 36 systemic lupus erythematosus (SLE) patients with or without antiphospholipid antibodies (aPL), including aCL and lupus anticoagulants, to clarify the possible effects of aPL on apo H levels in vivo.
The apo H levels were low in SLE patients as compared with 22 healthy controls. However, no associations were found between apo H levels and circulating aPL or clinical features of the antiphospholipid antibody syndrome. A secondary hyperlipidemic state, which probably related to lupus nephritis (proteinuria) and/or prednisolone treatment, increased apo H levels in SLE patients. |
| doi_str_mv | 10.1177/096120339200100305 |
| format | Article |
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The apo H levels were low in SLE patients as compared with 22 healthy controls. However, no associations were found between apo H levels and circulating aPL or clinical features of the antiphospholipid antibody syndrome. A secondary hyperlipidemic state, which probably related to lupus nephritis (proteinuria) and/or prednisolone treatment, increased apo H levels in SLE patients.</description><identifier>ISSN: 0961-2033</identifier><identifier>EISSN: 1477-0962</identifier><identifier>DOI: 10.1177/096120339200100305</identifier><identifier>PMID: 1301975</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Adult ; Aged ; Antibodies, Anticardiolipin - blood ; Antibodies, Antiphospholipid - blood ; Antiphospholipid Syndrome - blood ; Antiphospholipid Syndrome - immunology ; Apolipoproteins - blood ; beta 2-Glycoprotein I ; Female ; Glycoproteins - blood ; Humans ; Lupus Coagulation Inhibitor - blood ; Lupus Erythematosus, Systemic - blood ; Lupus Erythematosus, Systemic - immunology ; Lupus Nephritis - blood ; Lupus Nephritis - immunology ; Male ; Middle Aged ; Proteinuria - blood ; Proteinuria - immunology</subject><ispartof>Lupus, 1992-05, Vol.1 (3), p.145-149</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-4e810741d51250457db9e9fc7b5c09590c500c555851ed1c24e201bda28db3923</citedby><cites>FETCH-LOGICAL-c370t-4e810741d51250457db9e9fc7b5c09590c500c555851ed1c24e201bda28db3923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/096120339200100305$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/096120339200100305$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1301975$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ichikawa, Yukinobu</creatorcontrib><creatorcontrib>Takamatsu, Kazunaga</creatorcontrib><creatorcontrib>Shimizu, Hiroaki</creatorcontrib><creatorcontrib>Uchiyama, Mitsuaki</creatorcontrib><creatorcontrib>Moriuchi, Junko</creatorcontrib><creatorcontrib>Takaya, Masatoshi</creatorcontrib><creatorcontrib>Kobayashi, Nobumasa</creatorcontrib><creatorcontrib>Kawada, Tsutomu</creatorcontrib><creatorcontrib>Arimori, Shigeru</creatorcontrib><title>Serum Apolipoprotein H Levels in Systemic Lupus Erythematosus Are Not Influenced by Antiphospholipid Antibodies</title><title>Lupus</title><addtitle>Lupus</addtitle><description>Anticardiolipin antibodies (aCL) were recently discovered to recognize a complex consisting of phospholipids and apolipoprotein H (apo H). In this study, we determined the serum apo H levels in 36 systemic lupus erythematosus (SLE) patients with or without antiphospholipid antibodies (aPL), including aCL and lupus anticoagulants, to clarify the possible effects of aPL on apo H levels in vivo.
The apo H levels were low in SLE patients as compared with 22 healthy controls. However, no associations were found between apo H levels and circulating aPL or clinical features of the antiphospholipid antibody syndrome. A secondary hyperlipidemic state, which probably related to lupus nephritis (proteinuria) and/or prednisolone treatment, increased apo H levels in SLE patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibodies, Anticardiolipin - blood</subject><subject>Antibodies, Antiphospholipid - blood</subject><subject>Antiphospholipid Syndrome - blood</subject><subject>Antiphospholipid Syndrome - immunology</subject><subject>Apolipoproteins - blood</subject><subject>beta 2-Glycoprotein I</subject><subject>Female</subject><subject>Glycoproteins - blood</subject><subject>Humans</subject><subject>Lupus Coagulation Inhibitor - blood</subject><subject>Lupus Erythematosus, Systemic - blood</subject><subject>Lupus Erythematosus, Systemic - immunology</subject><subject>Lupus Nephritis - blood</subject><subject>Lupus Nephritis - immunology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Proteinuria - blood</subject><subject>Proteinuria - immunology</subject><issn>0961-2033</issn><issn>1477-0962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFLwzAUxoMoOqf_gCDkpKe6l6RZmuMYUwdDD-q5tMmb62ibmrTC_nszJ3gQPDySl-_3Psj7CLlicMeYUhPQU8ZBCM0BGIAAeURGLFUqiQo_JqM9kOyJM3IewhYiw_T0lJwyAUwrOSLuBf3Q0Fnn6qpznXc9Vi19pCv8xDrQeH_ZhR6bytDV0A2BLvyu32BT9C7EbuaRPrmeLtt1PWBr0NJyR2dtX3UbF2JF18p-P5TOVhguyMm6qANe_pxj8na_eJ0_Jqvnh-V8tkqMUNAnKWYMVMqsZFxCKpUtNeq1UaU0oKUGIyGWlJlkaJnhKXJgpS14Zsu4DzEmtwff-KWPAUOfN1UwWNdFi24IuZJplgmpdCRv_ieF5FORZhHkB9B4F4LHdd75qin8LmeQ7_PI_-YRh65_3IeyQfs7cggg6pODHop3zLdu8G1cy3-OX864kqo</recordid><startdate>19920501</startdate><enddate>19920501</enddate><creator>Ichikawa, Yukinobu</creator><creator>Takamatsu, Kazunaga</creator><creator>Shimizu, Hiroaki</creator><creator>Uchiyama, Mitsuaki</creator><creator>Moriuchi, Junko</creator><creator>Takaya, Masatoshi</creator><creator>Kobayashi, Nobumasa</creator><creator>Kawada, Tsutomu</creator><creator>Arimori, Shigeru</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>19920501</creationdate><title>Serum Apolipoprotein H Levels in Systemic Lupus Erythematosus Are Not Influenced by Antiphospholipid Antibodies</title><author>Ichikawa, Yukinobu ; Takamatsu, Kazunaga ; Shimizu, Hiroaki ; Uchiyama, Mitsuaki ; Moriuchi, Junko ; Takaya, Masatoshi ; Kobayashi, Nobumasa ; Kawada, Tsutomu ; Arimori, Shigeru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-4e810741d51250457db9e9fc7b5c09590c500c555851ed1c24e201bda28db3923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antibodies, Anticardiolipin - blood</topic><topic>Antibodies, Antiphospholipid - blood</topic><topic>Antiphospholipid Syndrome - blood</topic><topic>Antiphospholipid Syndrome - immunology</topic><topic>Apolipoproteins - blood</topic><topic>beta 2-Glycoprotein I</topic><topic>Female</topic><topic>Glycoproteins - blood</topic><topic>Humans</topic><topic>Lupus Coagulation Inhibitor - blood</topic><topic>Lupus Erythematosus, Systemic - blood</topic><topic>Lupus Erythematosus, Systemic - immunology</topic><topic>Lupus Nephritis - blood</topic><topic>Lupus Nephritis - immunology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Proteinuria - blood</topic><topic>Proteinuria - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ichikawa, Yukinobu</creatorcontrib><creatorcontrib>Takamatsu, Kazunaga</creatorcontrib><creatorcontrib>Shimizu, Hiroaki</creatorcontrib><creatorcontrib>Uchiyama, Mitsuaki</creatorcontrib><creatorcontrib>Moriuchi, Junko</creatorcontrib><creatorcontrib>Takaya, Masatoshi</creatorcontrib><creatorcontrib>Kobayashi, Nobumasa</creatorcontrib><creatorcontrib>Kawada, Tsutomu</creatorcontrib><creatorcontrib>Arimori, Shigeru</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Lupus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ichikawa, Yukinobu</au><au>Takamatsu, Kazunaga</au><au>Shimizu, Hiroaki</au><au>Uchiyama, Mitsuaki</au><au>Moriuchi, Junko</au><au>Takaya, Masatoshi</au><au>Kobayashi, Nobumasa</au><au>Kawada, Tsutomu</au><au>Arimori, Shigeru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Apolipoprotein H Levels in Systemic Lupus Erythematosus Are Not Influenced by Antiphospholipid Antibodies</atitle><jtitle>Lupus</jtitle><addtitle>Lupus</addtitle><date>1992-05-01</date><risdate>1992</risdate><volume>1</volume><issue>3</issue><spage>145</spage><epage>149</epage><pages>145-149</pages><issn>0961-2033</issn><eissn>1477-0962</eissn><abstract>Anticardiolipin antibodies (aCL) were recently discovered to recognize a complex consisting of phospholipids and apolipoprotein H (apo H). In this study, we determined the serum apo H levels in 36 systemic lupus erythematosus (SLE) patients with or without antiphospholipid antibodies (aPL), including aCL and lupus anticoagulants, to clarify the possible effects of aPL on apo H levels in vivo.
The apo H levels were low in SLE patients as compared with 22 healthy controls. However, no associations were found between apo H levels and circulating aPL or clinical features of the antiphospholipid antibody syndrome. A secondary hyperlipidemic state, which probably related to lupus nephritis (proteinuria) and/or prednisolone treatment, increased apo H levels in SLE patients.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>1301975</pmid><doi>10.1177/096120339200100305</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Antibodies, Anticardiolipin - blood Antibodies, Antiphospholipid - blood Antiphospholipid Syndrome - blood Antiphospholipid Syndrome - immunology Apolipoproteins - blood beta 2-Glycoprotein I Female Glycoproteins - blood Humans Lupus Coagulation Inhibitor - blood Lupus Erythematosus, Systemic - blood Lupus Erythematosus, Systemic - immunology Lupus Nephritis - blood Lupus Nephritis - immunology Male Middle Aged Proteinuria - blood Proteinuria - immunology |
| title | Serum Apolipoprotein H Levels in Systemic Lupus Erythematosus Are Not Influenced by Antiphospholipid Antibodies |
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