In vivo follow-up of rat tumor models with 2-deoxy-2-[F-18]fluoro-D-glucose/dual-head coincidence gamma camera imaging
Before studying the impact of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG) imaging with a dual-head coincidence gamma camera (DHC) for the follow-up of animal tumor models, we wanted to optimize this technique. Three different animal tumor models (osteosarcoma, melanoma, and breast cancer) were studied af...
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| Veröffentlicht in: | Molecular imaging and biology 2005-05, Vol.7 (3), p.220-228 |
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| creator | Monteil, Jacques Dutour, Aurélie Akla, Barbara Chianéa, Thierry Le Brun, Valérie Grossin, Laurent Paraf, François Petegnief, Yolande Vandroux, Jean-Claude Rigaud, Michel Sturtz, Franck G |
| description | Before studying the impact of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG) imaging with a dual-head coincidence gamma camera (DHC) for the follow-up of animal tumor models, we wanted to optimize this technique.
Three different animal tumor models (osteosarcoma, melanoma, and breast cancer) were studied after FDG injection. Dynamic and dual time point FDG/DHC imaging were studied from one hour to five hours postinjection. In vitro tumor cell FDG uptake was assessed in eight different tumor cell lines. In one model (osteosarcoma), tumor growth, lung metastasis emergence, and survival were assessed by classical clinical follow-up and compared to FDG imaging in a control group (n = 6) and in a group treated by endostatin liposome complexes (n = 6).
Images obtained five hours after injection were more reliable for tumor growth follow-up than standard images (one hour). In vitro tumor cell FDG uptake confirmed in vivo imaging studies. In eight different tumor cell lines the FDG uptake was higher after five hours incubation than after one hour (p < 0.002). With FDG follow-up, we found that FDG uptake was strongly correlated with survival and that lung metastasis larger than 5 mm could be detected.
Using the optimization proposed above, DHC/FDG functional imaging seems to be a powerful tool to study rat tumor models and to help develop novel cancer therapies. |
| doi_str_mv | 10.1007/s11307-005-4115-9 |
| format | Article |
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Three different animal tumor models (osteosarcoma, melanoma, and breast cancer) were studied after FDG injection. Dynamic and dual time point FDG/DHC imaging were studied from one hour to five hours postinjection. In vitro tumor cell FDG uptake was assessed in eight different tumor cell lines. In one model (osteosarcoma), tumor growth, lung metastasis emergence, and survival were assessed by classical clinical follow-up and compared to FDG imaging in a control group (n = 6) and in a group treated by endostatin liposome complexes (n = 6).
Images obtained five hours after injection were more reliable for tumor growth follow-up than standard images (one hour). In vitro tumor cell FDG uptake confirmed in vivo imaging studies. In eight different tumor cell lines the FDG uptake was higher after five hours incubation than after one hour (p < 0.002). With FDG follow-up, we found that FDG uptake was strongly correlated with survival and that lung metastasis larger than 5 mm could be detected.
Using the optimization proposed above, DHC/FDG functional imaging seems to be a powerful tool to study rat tumor models and to help develop novel cancer therapies.</description><identifier>ISSN: 1536-1632</identifier><identifier>EISSN: 1860-2002</identifier><identifier>DOI: 10.1007/s11307-005-4115-9</identifier><identifier>PMID: 15912426</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Animals ; Breast cancer ; Cancer therapies ; Cell Line, Tumor ; Diagnostic Imaging ; Disease Models, Animal ; Fluorodeoxyglucose F18 - pharmacology ; Follow-Up Studies ; Gamma Cameras ; Humans ; Neoplasm Metastasis - pathology ; Neoplasm Transplantation ; Neoplasms - diagnosis ; Neoplasms - metabolism ; Neoplasms - pathology ; Rats ; Rats, Sprague-Dawley ; Survival Rate ; Time Factors ; Tumors</subject><ispartof>Molecular imaging and biology, 2005-05, Vol.7 (3), p.220-228</ispartof><rights>Academy of Molecular Imaging 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c358t-214cc6fd2f24f4f515faaaf64401eb3c492e65f4c09e97c281402be2d64f90f73</citedby><cites>FETCH-LOGICAL-c358t-214cc6fd2f24f4f515faaaf64401eb3c492e65f4c09e97c281402be2d64f90f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15912426$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Monteil, Jacques</creatorcontrib><creatorcontrib>Dutour, Aurélie</creatorcontrib><creatorcontrib>Akla, Barbara</creatorcontrib><creatorcontrib>Chianéa, Thierry</creatorcontrib><creatorcontrib>Le Brun, Valérie</creatorcontrib><creatorcontrib>Grossin, Laurent</creatorcontrib><creatorcontrib>Paraf, François</creatorcontrib><creatorcontrib>Petegnief, Yolande</creatorcontrib><creatorcontrib>Vandroux, Jean-Claude</creatorcontrib><creatorcontrib>Rigaud, Michel</creatorcontrib><creatorcontrib>Sturtz, Franck G</creatorcontrib><title>In vivo follow-up of rat tumor models with 2-deoxy-2-[F-18]fluoro-D-glucose/dual-head coincidence gamma camera imaging</title><title>Molecular imaging and biology</title><addtitle>Mol Imaging Biol</addtitle><description>Before studying the impact of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG) imaging with a dual-head coincidence gamma camera (DHC) for the follow-up of animal tumor models, we wanted to optimize this technique.
Three different animal tumor models (osteosarcoma, melanoma, and breast cancer) were studied after FDG injection. Dynamic and dual time point FDG/DHC imaging were studied from one hour to five hours postinjection. In vitro tumor cell FDG uptake was assessed in eight different tumor cell lines. In one model (osteosarcoma), tumor growth, lung metastasis emergence, and survival were assessed by classical clinical follow-up and compared to FDG imaging in a control group (n = 6) and in a group treated by endostatin liposome complexes (n = 6).
Images obtained five hours after injection were more reliable for tumor growth follow-up than standard images (one hour). In vitro tumor cell FDG uptake confirmed in vivo imaging studies. In eight different tumor cell lines the FDG uptake was higher after five hours incubation than after one hour (p < 0.002). With FDG follow-up, we found that FDG uptake was strongly correlated with survival and that lung metastasis larger than 5 mm could be detected.
Using the optimization proposed above, DHC/FDG functional imaging seems to be a powerful tool to study rat tumor models and to help develop novel cancer therapies.</description><subject>Animals</subject><subject>Breast cancer</subject><subject>Cancer therapies</subject><subject>Cell Line, Tumor</subject><subject>Diagnostic Imaging</subject><subject>Disease Models, Animal</subject><subject>Fluorodeoxyglucose F18 - pharmacology</subject><subject>Follow-Up Studies</subject><subject>Gamma Cameras</subject><subject>Humans</subject><subject>Neoplasm Metastasis - pathology</subject><subject>Neoplasm Transplantation</subject><subject>Neoplasms - diagnosis</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Survival Rate</subject><subject>Time Factors</subject><subject>Tumors</subject><issn>1536-1632</issn><issn>1860-2002</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc9rFDEUgAex2B_6B3iR4EFPad_LJJnkKK2thUIvehIJ2UyynZKZrMlka_97Z9kFwUNP7x2-98Hja5r3COcI0F0UxBY6CiAoRxRUv2pOUEmgDIC9XnbRSoqyZcfNaSmPANgha980xyg0Ms7kSbO9nch22CYSUozpidYNSYFkO5O5jimTMfU-FvI0zA-E0d6nP8-U0Z_XFNWvEGvKiV7RdawuFX_RVxvpg7c9cWmY3ND7yXmytuNoibOjz5YMo10P0_ptcxRsLP7dYZ41P66_fr_8Ru_ub24vv9xR1wo1U4bcORl6FhgPPAgUwVobJOeAftU6rpmXInAH2uvOMYUc2MqzXvKgIXTtWfN5793k9Lv6MptxKM7HaCefajGd4Eqh0mohP71Iyk5JpplewI__gY-p5mn5YrEB1yA4WyDcQy6nUrIPZpOX1_OzQTC7dmbfziztzK6d2Yk_HMR1Nfr-38UhVvsXCdOTbw</recordid><startdate>200505</startdate><enddate>200505</enddate><creator>Monteil, Jacques</creator><creator>Dutour, Aurélie</creator><creator>Akla, Barbara</creator><creator>Chianéa, Thierry</creator><creator>Le Brun, Valérie</creator><creator>Grossin, Laurent</creator><creator>Paraf, François</creator><creator>Petegnief, Yolande</creator><creator>Vandroux, Jean-Claude</creator><creator>Rigaud, Michel</creator><creator>Sturtz, Franck G</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>L6V</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>200505</creationdate><title>In vivo follow-up of rat tumor models with 2-deoxy-2-[F-18]fluoro-D-glucose/dual-head coincidence gamma camera imaging</title><author>Monteil, Jacques ; Dutour, Aurélie ; Akla, Barbara ; Chianéa, Thierry ; Le Brun, Valérie ; Grossin, Laurent ; Paraf, François ; Petegnief, Yolande ; Vandroux, Jean-Claude ; Rigaud, Michel ; Sturtz, Franck G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c358t-214cc6fd2f24f4f515faaaf64401eb3c492e65f4c09e97c281402be2d64f90f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Breast cancer</topic><topic>Cancer therapies</topic><topic>Cell Line, Tumor</topic><topic>Diagnostic Imaging</topic><topic>Disease Models, Animal</topic><topic>Fluorodeoxyglucose F18 - 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Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>Molecular imaging and biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Monteil, Jacques</au><au>Dutour, Aurélie</au><au>Akla, Barbara</au><au>Chianéa, Thierry</au><au>Le Brun, Valérie</au><au>Grossin, Laurent</au><au>Paraf, François</au><au>Petegnief, Yolande</au><au>Vandroux, Jean-Claude</au><au>Rigaud, Michel</au><au>Sturtz, Franck G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo follow-up of rat tumor models with 2-deoxy-2-[F-18]fluoro-D-glucose/dual-head coincidence gamma camera imaging</atitle><jtitle>Molecular imaging and biology</jtitle><addtitle>Mol Imaging Biol</addtitle><date>2005-05</date><risdate>2005</risdate><volume>7</volume><issue>3</issue><spage>220</spage><epage>228</epage><pages>220-228</pages><issn>1536-1632</issn><eissn>1860-2002</eissn><abstract>Before studying the impact of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG) imaging with a dual-head coincidence gamma camera (DHC) for the follow-up of animal tumor models, we wanted to optimize this technique.
Three different animal tumor models (osteosarcoma, melanoma, and breast cancer) were studied after FDG injection. Dynamic and dual time point FDG/DHC imaging were studied from one hour to five hours postinjection. In vitro tumor cell FDG uptake was assessed in eight different tumor cell lines. In one model (osteosarcoma), tumor growth, lung metastasis emergence, and survival were assessed by classical clinical follow-up and compared to FDG imaging in a control group (n = 6) and in a group treated by endostatin liposome complexes (n = 6).
Images obtained five hours after injection were more reliable for tumor growth follow-up than standard images (one hour). In vitro tumor cell FDG uptake confirmed in vivo imaging studies. In eight different tumor cell lines the FDG uptake was higher after five hours incubation than after one hour (p < 0.002). With FDG follow-up, we found that FDG uptake was strongly correlated with survival and that lung metastasis larger than 5 mm could be detected.
Using the optimization proposed above, DHC/FDG functional imaging seems to be a powerful tool to study rat tumor models and to help develop novel cancer therapies.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>15912426</pmid><doi>10.1007/s11307-005-4115-9</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals Breast cancer Cancer therapies Cell Line, Tumor Diagnostic Imaging Disease Models, Animal Fluorodeoxyglucose F18 - pharmacology Follow-Up Studies Gamma Cameras Humans Neoplasm Metastasis - pathology Neoplasm Transplantation Neoplasms - diagnosis Neoplasms - metabolism Neoplasms - pathology Rats Rats, Sprague-Dawley Survival Rate Time Factors Tumors |
| title | In vivo follow-up of rat tumor models with 2-deoxy-2-[F-18]fluoro-D-glucose/dual-head coincidence gamma camera imaging |
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