A novel automated assay with dual-color hybridization for single-nucleotide polymorphisms genotyping on gold magnetic nanoparticle array

A high-throughput and cost-effective single-nucleotide polymorphism (SNP) genotyping method based on a gold magnetic nanoparticle (GMNP) array with dual-color hybridization has been designed. Biotinylated single-strand polymerase chain reaction (PCR) products containing the SNP locus were captured b...

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Veröffentlicht in:	Analytical biochemistry 2010-10, Vol.405 (1), p.141-143
Hauptverfasser:	Li, Song, Liu, Hongna, Liu, Lishang, Tian, Lan, He, Nongyue
Format:	Artikel
Sprache:	eng
Schlagworte:	Automation Biotinylation DNA, Single-Stranded - chemistry Dual-color hybridization Genotype Gold - chemistry Gold magnetic nanoparticle array Magnetics Metal Nanoparticles - chemistry Nucleic Acid Hybridization - methods Polymorphism, Single Nucleotide Single-nucleotide polymorphisms Streptavidin - metabolism
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