Expression of vascular endothelial growth factor in renal cell carcinoma and the relation to angiogenesis and p53 protein expression
Background and Objectives: Vascular endothelial growth factor (VEGF) seems to play an important role in tumor angiogenesis. The tumor‐suppressor gene p53 has been thought to regulate VEGF expression. We investigated the effect of VEGF expression on renal cell carcinoma (RCC) and the correlation betw...
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| Veröffentlicht in: | Journal of surgical oncology 2001-05, Vol.77 (1), p.55-60 |
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| creator | Lee, Ji Shin Kim, Hyung Seok Jung, Jong Jae Park, Chang Soo Lee, Min Cheol |
| description | Background and Objectives:
Vascular endothelial growth factor (VEGF) seems to play an important role in tumor angiogenesis. The tumor‐suppressor gene p53 has been thought to regulate VEGF expression. We investigated the effect of VEGF expression on renal cell carcinoma (RCC) and the correlation between the expression of VEGF and tumor angiogenesis and p53 protein expression.
Methods:
Sixty‐two RCCs were examined by immunohistochemical studies with anti‐VEGF, anti‐p53, and anti‐CD34 antibodies.
Results:
Forty tumors (80.6%) were classified as VEGF positive, and 28 tumors (45.2%) were positive for p53 protein. The microvessel density was 75.3 ± 33.5. A significant correlation was found between VEGF expression and both the nuclear grade (P |
| doi_str_mv | 10.1002/jso.1066 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_754880390</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>754880390</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4156-feaafed45009733f66c7843c97cbbec2dde5e1d36b3ae4ecfa76d947cf2722463</originalsourceid><addsrcrecordid>eNp9kU9vEzEQxS0EomlB4hMgS0iUy4K99trrIyolUFVUqPyRuFgT7zh12ayDvaHtnQ-OQ1bhBBfbmvn5zTw9Qp5w9pIzVr-6zrE8lLpHZpwZVRlm2vtkVlp1JbVhB-Qw52vGmDFKPiQHnAspZStn5Nfp7TphziEONHr6E7Lb9JAoDl0cr7AP0NNlijfjFfXgxphoGGjCoZQd9uWA5MIQV0Bh6Gj5UZo9jFu5MZbaMsQlDphD_gOsG0HXKY5YVHA_-RF54KHP-Hi6j8jnt6efTt5V5xfz9yevzysneaMqjwAeO9kUH1oIr5TTrRTOaLdYoKu7DhvknVALASjRedCqM1I7X-u6lkockeOdblnhxwbzaFchb23AgHGTrW5k2zJhWCGf_59kbd1KxQv4Yge6FHNO6O06hRWkO8uZ3WZjSzZ2m01Bn06am8UKu7_gFEYBnk1ASQF6n2BwIe85o3jxUKhqR92EHu_-Oc6eXV5MYyc-5BFv9zyk71ZpoRv79cPczvXZt49vvkh7KX4DPhW21Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70828461</pqid></control><display><type>article</type><title>Expression of vascular endothelial growth factor in renal cell carcinoma and the relation to angiogenesis and p53 protein expression</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Lee, Ji Shin ; Kim, Hyung Seok ; Jung, Jong Jae ; Park, Chang Soo ; Lee, Min Cheol</creator><creatorcontrib>Lee, Ji Shin ; Kim, Hyung Seok ; Jung, Jong Jae ; Park, Chang Soo ; Lee, Min Cheol</creatorcontrib><description>Background and Objectives:
Vascular endothelial growth factor (VEGF) seems to play an important role in tumor angiogenesis. The tumor‐suppressor gene p53 has been thought to regulate VEGF expression. We investigated the effect of VEGF expression on renal cell carcinoma (RCC) and the correlation between the expression of VEGF and tumor angiogenesis and p53 protein expression.
Methods:
Sixty‐two RCCs were examined by immunohistochemical studies with anti‐VEGF, anti‐p53, and anti‐CD34 antibodies.
Results:
Forty tumors (80.6%) were classified as VEGF positive, and 28 tumors (45.2%) were positive for p53 protein. The microvessel density was 75.3 ± 33.5. A significant correlation was found between VEGF expression and both the nuclear grade (P < 0.05) and the TNM stage (P < 0.05). The tumors with VEGF expression had a significantly higher microvessel density than those without VEGF expression (P < 0.01). There was no statistically significant correlation between p53 protein and VEGF expression. No statistically significant differences in survival were found to be associated with microvessel density, VEGF expression or p53 protein expression. By using multivariate survival analyses, nuclear grade (P < 0.05) and TNM stage (P < 0.05) were the only independent prognostic factors.
Conclusions:
Our data do not show a direct regulation of VEGF expression by p53. We suggest that VEGF expression plays a role in the promotion of angiogenesis in RCC. J. Surg. Oncol. 2001; 77:55–60. © 2001 Wiley‐Liss, Inc.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.1066</identifier><identifier>PMID: 11344484</identifier><identifier>CODEN: JSONAU</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Adult ; Aged ; angiogenesis ; Biological and medical sciences ; Carcinoma, Renal Cell - blood supply ; Carcinoma, Renal Cell - metabolism ; Carcinoma, Renal Cell - pathology ; Endothelial Growth Factors - biosynthesis ; Endothelial Growth Factors - physiology ; Female ; Humans ; Kidney Neoplasms - blood supply ; Kidney Neoplasms - metabolism ; Kidney Neoplasms - pathology ; Kidneys ; Lymphokines - biosynthesis ; Lymphokines - physiology ; Male ; Medical sciences ; Middle Aged ; Neovascularization, Pathologic ; Nephrology. Urinary tract diseases ; p53 ; p53, angiogenesis ; renal cell carcinoma ; Tumor Suppressor Protein p53 - biosynthesis ; Tumors of the urinary system ; vascular endothelial growth factor ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors</subject><ispartof>Journal of surgical oncology, 2001-05, Vol.77 (1), p.55-60</ispartof><rights>Copyright © 2001 Wiley‐Liss, Inc.</rights><rights>2001 INIST-CNRS</rights><rights>Copyright 2001 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4156-feaafed45009733f66c7843c97cbbec2dde5e1d36b3ae4ecfa76d947cf2722463</citedby><cites>FETCH-LOGICAL-c4156-feaafed45009733f66c7843c97cbbec2dde5e1d36b3ae4ecfa76d947cf2722463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjso.1066$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjso.1066$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=961463$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11344484$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Ji Shin</creatorcontrib><creatorcontrib>Kim, Hyung Seok</creatorcontrib><creatorcontrib>Jung, Jong Jae</creatorcontrib><creatorcontrib>Park, Chang Soo</creatorcontrib><creatorcontrib>Lee, Min Cheol</creatorcontrib><title>Expression of vascular endothelial growth factor in renal cell carcinoma and the relation to angiogenesis and p53 protein expression</title><title>Journal of surgical oncology</title><addtitle>J. Surg. Oncol</addtitle><description>Background and Objectives:
Vascular endothelial growth factor (VEGF) seems to play an important role in tumor angiogenesis. The tumor‐suppressor gene p53 has been thought to regulate VEGF expression. We investigated the effect of VEGF expression on renal cell carcinoma (RCC) and the correlation between the expression of VEGF and tumor angiogenesis and p53 protein expression.
Methods:
Sixty‐two RCCs were examined by immunohistochemical studies with anti‐VEGF, anti‐p53, and anti‐CD34 antibodies.
Results:
Forty tumors (80.6%) were classified as VEGF positive, and 28 tumors (45.2%) were positive for p53 protein. The microvessel density was 75.3 ± 33.5. A significant correlation was found between VEGF expression and both the nuclear grade (P < 0.05) and the TNM stage (P < 0.05). The tumors with VEGF expression had a significantly higher microvessel density than those without VEGF expression (P < 0.01). There was no statistically significant correlation between p53 protein and VEGF expression. No statistically significant differences in survival were found to be associated with microvessel density, VEGF expression or p53 protein expression. By using multivariate survival analyses, nuclear grade (P < 0.05) and TNM stage (P < 0.05) were the only independent prognostic factors.
Conclusions:
Our data do not show a direct regulation of VEGF expression by p53. We suggest that VEGF expression plays a role in the promotion of angiogenesis in RCC. J. Surg. Oncol. 2001; 77:55–60. © 2001 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>Aged</subject><subject>angiogenesis</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Renal Cell - blood supply</subject><subject>Carcinoma, Renal Cell - metabolism</subject><subject>Carcinoma, Renal Cell - pathology</subject><subject>Endothelial Growth Factors - biosynthesis</subject><subject>Endothelial Growth Factors - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Kidney Neoplasms - blood supply</subject><subject>Kidney Neoplasms - metabolism</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidneys</subject><subject>Lymphokines - biosynthesis</subject><subject>Lymphokines - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neovascularization, Pathologic</subject><subject>Nephrology. Urinary tract diseases</subject><subject>p53</subject><subject>p53, angiogenesis</subject><subject>renal cell carcinoma</subject><subject>Tumor Suppressor Protein p53 - biosynthesis</subject><subject>Tumors of the urinary system</subject><subject>vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A</subject><subject>Vascular Endothelial Growth Factors</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9vEzEQxS0EomlB4hMgS0iUy4K99trrIyolUFVUqPyRuFgT7zh12ayDvaHtnQ-OQ1bhBBfbmvn5zTw9Qp5w9pIzVr-6zrE8lLpHZpwZVRlm2vtkVlp1JbVhB-Qw52vGmDFKPiQHnAspZStn5Nfp7TphziEONHr6E7Lb9JAoDl0cr7AP0NNlijfjFfXgxphoGGjCoZQd9uWA5MIQV0Bh6Gj5UZo9jFu5MZbaMsQlDphD_gOsG0HXKY5YVHA_-RF54KHP-Hi6j8jnt6efTt5V5xfz9yevzysneaMqjwAeO9kUH1oIr5TTrRTOaLdYoKu7DhvknVALASjRedCqM1I7X-u6lkockeOdblnhxwbzaFchb23AgHGTrW5k2zJhWCGf_59kbd1KxQv4Yge6FHNO6O06hRWkO8uZ3WZjSzZ2m01Bn06am8UKu7_gFEYBnk1ASQF6n2BwIe85o3jxUKhqR92EHu_-Oc6eXV5MYyc-5BFv9zyk71ZpoRv79cPczvXZt49vvkh7KX4DPhW21Q</recordid><startdate>200105</startdate><enddate>200105</enddate><creator>Lee, Ji Shin</creator><creator>Kim, Hyung Seok</creator><creator>Jung, Jong Jae</creator><creator>Park, Chang Soo</creator><creator>Lee, Min Cheol</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TO</scope><scope>H94</scope></search><sort><creationdate>200105</creationdate><title>Expression of vascular endothelial growth factor in renal cell carcinoma and the relation to angiogenesis and p53 protein expression</title><author>Lee, Ji Shin ; Kim, Hyung Seok ; Jung, Jong Jae ; Park, Chang Soo ; Lee, Min Cheol</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4156-feaafed45009733f66c7843c97cbbec2dde5e1d36b3ae4ecfa76d947cf2722463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Aged</topic><topic>angiogenesis</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Renal Cell - blood supply</topic><topic>Carcinoma, Renal Cell - metabolism</topic><topic>Carcinoma, Renal Cell - pathology</topic><topic>Endothelial Growth Factors - biosynthesis</topic><topic>Endothelial Growth Factors - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Kidney Neoplasms - blood supply</topic><topic>Kidney Neoplasms - metabolism</topic><topic>Kidney Neoplasms - pathology</topic><topic>Kidneys</topic><topic>Lymphokines - biosynthesis</topic><topic>Lymphokines - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neovascularization, Pathologic</topic><topic>Nephrology. Urinary tract diseases</topic><topic>p53</topic><topic>p53, angiogenesis</topic><topic>renal cell carcinoma</topic><topic>Tumor Suppressor Protein p53 - biosynthesis</topic><topic>Tumors of the urinary system</topic><topic>vascular endothelial growth factor</topic><topic>Vascular Endothelial Growth Factor A</topic><topic>Vascular Endothelial Growth Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Ji Shin</creatorcontrib><creatorcontrib>Kim, Hyung Seok</creatorcontrib><creatorcontrib>Jung, Jong Jae</creatorcontrib><creatorcontrib>Park, Chang Soo</creatorcontrib><creatorcontrib>Lee, Min Cheol</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Ji Shin</au><au>Kim, Hyung Seok</au><au>Jung, Jong Jae</au><au>Park, Chang Soo</au><au>Lee, Min Cheol</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of vascular endothelial growth factor in renal cell carcinoma and the relation to angiogenesis and p53 protein expression</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J. Surg. Oncol</addtitle><date>2001-05</date><risdate>2001</risdate><volume>77</volume><issue>1</issue><spage>55</spage><epage>60</epage><pages>55-60</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><coden>JSONAU</coden><abstract>Background and Objectives:
Vascular endothelial growth factor (VEGF) seems to play an important role in tumor angiogenesis. The tumor‐suppressor gene p53 has been thought to regulate VEGF expression. We investigated the effect of VEGF expression on renal cell carcinoma (RCC) and the correlation between the expression of VEGF and tumor angiogenesis and p53 protein expression.
Methods:
Sixty‐two RCCs were examined by immunohistochemical studies with anti‐VEGF, anti‐p53, and anti‐CD34 antibodies.
Results:
Forty tumors (80.6%) were classified as VEGF positive, and 28 tumors (45.2%) were positive for p53 protein. The microvessel density was 75.3 ± 33.5. A significant correlation was found between VEGF expression and both the nuclear grade (P < 0.05) and the TNM stage (P < 0.05). The tumors with VEGF expression had a significantly higher microvessel density than those without VEGF expression (P < 0.01). There was no statistically significant correlation between p53 protein and VEGF expression. No statistically significant differences in survival were found to be associated with microvessel density, VEGF expression or p53 protein expression. By using multivariate survival analyses, nuclear grade (P < 0.05) and TNM stage (P < 0.05) were the only independent prognostic factors.
Conclusions:
Our data do not show a direct regulation of VEGF expression by p53. We suggest that VEGF expression plays a role in the promotion of angiogenesis in RCC. J. Surg. Oncol. 2001; 77:55–60. © 2001 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>11344484</pmid><doi>10.1002/jso.1066</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged angiogenesis Biological and medical sciences Carcinoma, Renal Cell - blood supply Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - pathology Endothelial Growth Factors - biosynthesis Endothelial Growth Factors - physiology Female Humans Kidney Neoplasms - blood supply Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Kidneys Lymphokines - biosynthesis Lymphokines - physiology Male Medical sciences Middle Aged Neovascularization, Pathologic Nephrology. Urinary tract diseases p53 p53, angiogenesis renal cell carcinoma Tumor Suppressor Protein p53 - biosynthesis Tumors of the urinary system vascular endothelial growth factor Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors |
| title | Expression of vascular endothelial growth factor in renal cell carcinoma and the relation to angiogenesis and p53 protein expression |
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