p53 alterations in all stages of breast cancer
Overexpression of the nuclear phosphoprotein p53 is one of the most frequently detected abnormalities in human cancer and appears to be associated with mutation of the p53 gene. In this study of breast cancer, p53 overexpression was detected in two (15%) of 15 pure intraductal tumors, 73 (25%) of 29...
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| Veröffentlicht in: | Journal of surgical oncology 1991-12, Vol.48 (4), p.260-267 |
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| container_title | Journal of surgical oncology |
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| creator | Davidoff, Andrew M. Kerns, Billie-Jo M. Pence, Jeffrey C. Marks, Jeffrey R. Iglehart, J. Dirk |
| description | Overexpression of the nuclear phosphoprotein p53 is one of the most frequently detected abnormalities in human cancer and appears to be associated with mutation of the p53 gene. In this study of breast cancer, p53 overexpression was detected in two (15%) of 15 pure intraductal tumors, 73 (25%) of 291 primary invasive carcinomas, 13 (50%) of 26 lymph nodes containing metastatic breast cancer, and two of four established breast cancer cell lines. Sequence analysis of selected specimens confirmed that p53 overexpression was associated with mutation of the gene, while no mutations were detected in specimens without p53 overexpression. Thus, overexpression of p53 occurs in all stages of breast cancer and is consistently associated with the production of mutant proteins. Immuno‐histochemical analysis is a simple method which reliably predicts the presence of most p53 gene mutations in breast cancer specimens. |
| doi_str_mv | 10.1002/jso.2930480409 |
| format | Article |
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Immuno‐histochemical analysis is a simple method which reliably predicts the presence of most p53 gene mutations in breast cancer specimens.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.2930480409</identifier><identifier>PMID: 1745051</identifier><identifier>CODEN: JSONAU</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Base Sequence ; Biological and medical sciences ; Breast Neoplasms - genetics ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Exons - genetics ; expression ; Female ; Gene Expression ; Genes, p53 - genetics ; Genes, Tumor Suppressor ; Gynecology. Andrology. 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Dirk</creatorcontrib><title>p53 alterations in all stages of breast cancer</title><title>Journal of surgical oncology</title><addtitle>J. Surg. Oncol</addtitle><description>Overexpression of the nuclear phosphoprotein p53 is one of the most frequently detected abnormalities in human cancer and appears to be associated with mutation of the p53 gene. In this study of breast cancer, p53 overexpression was detected in two (15%) of 15 pure intraductal tumors, 73 (25%) of 291 primary invasive carcinomas, 13 (50%) of 26 lymph nodes containing metastatic breast cancer, and two of four established breast cancer cell lines. Sequence analysis of selected specimens confirmed that p53 overexpression was associated with mutation of the gene, while no mutations were detected in specimens without p53 overexpression. Thus, overexpression of p53 occurs in all stages of breast cancer and is consistently associated with the production of mutant proteins. Immuno‐histochemical analysis is a simple method which reliably predicts the presence of most p53 gene mutations in breast cancer specimens.</description><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Exons - genetics</subject><subject>expression</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Genes, p53 - genetics</subject><subject>Genes, Tumor Suppressor</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>immunohistochemical analysis</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Mutation</subject><subject>Neoplasm Staging</subject><subject>Tumor Suppressor Protein p53 - genetics</subject><subject>Tumor Suppressor Protein p53 - physiology</subject><subject>Tumors</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtLxDAQh4Mouj6u3oQeRE9dJ03SdI6y-BbforeQplOpdrdr0kX97610UbzoaRjm-80MH2ObHIYcINl7Ds0wQQEyAwm4wAYcMI0RMFtkgw5IYqkRVthqCM8AgJjKZbbMtVSg-IANp0pEtm7J27ZqJiGqJl1bR6G1TxSipoxyTza0kbMTR36dLZW2DrQxr2vs_vDgbnQcn18enYz2z2MnBWJMecGFUNKp3BIiaVlKrlHkmBZF6qAAzUkCFwnwRDiFWiYkBRXcKu2gFGtst9879c3rjEJrxlVwVNd2Qs0sGK1kpjHjqiN3_iYTJTETsgOHPeh8E4Kn0kx9Nbb-w3AwXypNp9L8qOwCW_PNs3xMxQ_eu-vm2_O5Dc7Wpe8MVeEbU1xBlnxh2GNvVU0f_xw1p7eXv16I-2wVWnr_zlr_YlIttDIPF0fm8fri5uxYnpor8Qk6jpj7</recordid><startdate>199112</startdate><enddate>199112</enddate><creator>Davidoff, Andrew M.</creator><creator>Kerns, Billie-Jo M.</creator><creator>Pence, Jeffrey C.</creator><creator>Marks, Jeffrey R.</creator><creator>Iglehart, J. 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Obstetrics</topic><topic>Humans</topic><topic>immunohistochemical analysis</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Mutation</topic><topic>Neoplasm Staging</topic><topic>Tumor Suppressor Protein p53 - genetics</topic><topic>Tumor Suppressor Protein p53 - physiology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Davidoff, Andrew M.</creatorcontrib><creatorcontrib>Kerns, Billie-Jo M.</creatorcontrib><creatorcontrib>Pence, Jeffrey C.</creatorcontrib><creatorcontrib>Marks, Jeffrey R.</creatorcontrib><creatorcontrib>Iglehart, J. 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| ispartof | Journal of surgical oncology, 1991-12, Vol.48 (4), p.260-267 |
| issn | 0022-4790 1096-9098 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Base Sequence Biological and medical sciences Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Exons - genetics expression Female Gene Expression Genes, p53 - genetics Genes, Tumor Suppressor Gynecology. Andrology. Obstetrics Humans immunohistochemical analysis Mammary gland diseases Medical sciences Mutation Neoplasm Staging Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - physiology Tumors |
| title | p53 alterations in all stages of breast cancer |
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