p53 gene mutation is not directly related to tumoricidal effects of preoperative radiochemohyperthermia therapy for rectal cancers
Background Several studies have recently demonstrated that apoptosis of cancer cells is triggered by diverse adjuvant cancer therapies and the induction of apoptosis correlates with the sensitivity of the primary tumor to such therapies. Methods We investigated the factors modulating adjuvant cancer...
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| Veröffentlicht in: | Journal of surgical oncology 1996-10, Vol.63 (2), p.87-90 |
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| container_title | Journal of surgical oncology |
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| creator | Ichikawa, Daisuke Yamaguchi, Toshiharu Shirasu, Morio Kitamura, Kazuya Inazawa, Johji Abe, Tatsuo Takahashi, Toshio |
| description | Background
Several studies have recently demonstrated that apoptosis of cancer cells is triggered by diverse adjuvant cancer therapies and the induction of apoptosis correlates with the sensitivity of the primary tumor to such therapies.
Methods
We investigated the factors modulating adjuvant cancer therapies by examining p53 gene mutations and chromosome 17p allelic losses in 15 rectal cancers treated by a preoperative combined therapy consisting of radiation, intraluminal hyperthermia and 5‐fluorouracil suppositories.
Results
The point mutations were detected in 7 of 15 (46.7%) tumors by single‐stranded conformational polymorphism and direct sequencing. Allelic losses at chromosome 17p were also detected in 7 of 15 (46.7%) tumors by dinucleotide‐repeat polymorphisms. There was no correlation between p53 gene abnormalities and the preoperative tumoricidal effect of the therapy.
Conclusions
We conclude that p53 gene abnormalities do not directly increase resistance to the combined adjuvant therapy. © 1996 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1096-9098(199610)63:2<87::AID-JSO3>3.0.CO;2-K |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_754879116</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>754879116</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4573-e85aafaa4fec436dae1c11b605bbf040c55caee529c5fcf338b665e79ed3889a3</originalsourceid><addsrcrecordid>eNp9kUGP0zAQhSMEWsrCT0DyAYndQ4odx07SRUirAqV0RQ8FwW3kOmNqNqmDnQK98stxaFUOIHyxPDP-5um9JLlidMwozZ5drObT-SWjlUwrWpUXrKoko5eST7LnZTGZXM9fpm9XS_6Cj-l4urzK0sWdZHSav5uMIiVL86Ki95MHIXyhlEZEfpaclfEUVTVKfnaCk8-4RdLuetVbtyU2kK3rSW096r7ZE4-N6rEmvSP9rnXealurhqAxsR-IM6Tz6Dr08fs3JF7V1ukNtm6zj8V-g761igy36vbEOE8GcCRotdXow8PknlFNwEfH-zz58PrV--mb9GY5m0-vb1Kdi4KnWAqljFJ5XJtzWStkmrG1pGK9NjSnWgitEEVWaWG04bxcSymwqLDmZVkpfp48PXA7777uMPTQ2qCxadQW3S5AIfLoCWMyTq4Ok9q7EDwa6Lxtld8DozBEAzBEA4PVMFgNh2hAcsigLABiNDBEAxwoTJexuojUx8f9u3WL9Yl5zCL2nxz7KmjVGB_tseE0luVFkTH6R9x32-D-L2X_F_YPXb_fkZoeqDb0-ONEVf4WZMELAR_fzUBwkX-SqwXM-C89I8iP</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>754879116</pqid></control><display><type>article</type><title>p53 gene mutation is not directly related to tumoricidal effects of preoperative radiochemohyperthermia therapy for rectal cancers</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Ichikawa, Daisuke ; Yamaguchi, Toshiharu ; Shirasu, Morio ; Kitamura, Kazuya ; Inazawa, Johji ; Abe, Tatsuo ; Takahashi, Toshio</creator><creatorcontrib>Ichikawa, Daisuke ; Yamaguchi, Toshiharu ; Shirasu, Morio ; Kitamura, Kazuya ; Inazawa, Johji ; Abe, Tatsuo ; Takahashi, Toshio</creatorcontrib><description>Background
Several studies have recently demonstrated that apoptosis of cancer cells is triggered by diverse adjuvant cancer therapies and the induction of apoptosis correlates with the sensitivity of the primary tumor to such therapies.
Methods
We investigated the factors modulating adjuvant cancer therapies by examining p53 gene mutations and chromosome 17p allelic losses in 15 rectal cancers treated by a preoperative combined therapy consisting of radiation, intraluminal hyperthermia and 5‐fluorouracil suppositories.
Results
The point mutations were detected in 7 of 15 (46.7%) tumors by single‐stranded conformational polymorphism and direct sequencing. Allelic losses at chromosome 17p were also detected in 7 of 15 (46.7%) tumors by dinucleotide‐repeat polymorphisms. There was no correlation between p53 gene abnormalities and the preoperative tumoricidal effect of the therapy.
Conclusions
We conclude that p53 gene abnormalities do not directly increase resistance to the combined adjuvant therapy. © 1996 Wiley‐Liss, Inc.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/(SICI)1096-9098(199610)63:2<87::AID-JSO3>3.0.CO;2-K</identifier><identifier>PMID: 8888799</identifier><identifier>CODEN: JSONAU</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Alleles ; Antimetabolites, Antineoplastic - administration & dosage ; apoptosis ; Biological and medical sciences ; cancer therapy ; Chemotherapy, Adjuvant ; Chromosome Deletion ; Chromosomes, Human, Pair 17 - genetics ; Fever ; Fluorouracil - administration & dosage ; Gastroenterology. Liver. Pancreas. Abdomen ; Genes, p53 - genetics ; Heterozygote ; Humans ; Medical sciences ; p53 ; Point Mutation ; Polymerase Chain Reaction - methods ; Polymorphism, Single-Stranded Conformational ; Radiotherapy, Adjuvant ; Rectal Neoplasms - drug therapy ; Rectal Neoplasms - genetics ; Rectal Neoplasms - radiotherapy ; Rectal Neoplasms - surgery ; Rectal Neoplasms - therapy ; sensitivity ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Suppositories ; Tumors</subject><ispartof>Journal of surgical oncology, 1996-10, Vol.63 (2), p.87-90</ispartof><rights>Copyright © 1996 Wiley‐Liss, Inc.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4573-e85aafaa4fec436dae1c11b605bbf040c55caee529c5fcf338b665e79ed3889a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291096-9098%28199610%2963%3A2%3C87%3A%3AAID-JSO3%3E3.0.CO%3B2-K$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291096-9098%28199610%2963%3A2%3C87%3A%3AAID-JSO3%3E3.0.CO%3B2-K$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2477210$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8888799$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ichikawa, Daisuke</creatorcontrib><creatorcontrib>Yamaguchi, Toshiharu</creatorcontrib><creatorcontrib>Shirasu, Morio</creatorcontrib><creatorcontrib>Kitamura, Kazuya</creatorcontrib><creatorcontrib>Inazawa, Johji</creatorcontrib><creatorcontrib>Abe, Tatsuo</creatorcontrib><creatorcontrib>Takahashi, Toshio</creatorcontrib><title>p53 gene mutation is not directly related to tumoricidal effects of preoperative radiochemohyperthermia therapy for rectal cancers</title><title>Journal of surgical oncology</title><addtitle>J. Surg. Oncol</addtitle><description>Background
Several studies have recently demonstrated that apoptosis of cancer cells is triggered by diverse adjuvant cancer therapies and the induction of apoptosis correlates with the sensitivity of the primary tumor to such therapies.
Methods
We investigated the factors modulating adjuvant cancer therapies by examining p53 gene mutations and chromosome 17p allelic losses in 15 rectal cancers treated by a preoperative combined therapy consisting of radiation, intraluminal hyperthermia and 5‐fluorouracil suppositories.
Results
The point mutations were detected in 7 of 15 (46.7%) tumors by single‐stranded conformational polymorphism and direct sequencing. Allelic losses at chromosome 17p were also detected in 7 of 15 (46.7%) tumors by dinucleotide‐repeat polymorphisms. There was no correlation between p53 gene abnormalities and the preoperative tumoricidal effect of the therapy.
Conclusions
We conclude that p53 gene abnormalities do not directly increase resistance to the combined adjuvant therapy. © 1996 Wiley‐Liss, Inc.</description><subject>Alleles</subject><subject>Antimetabolites, Antineoplastic - administration & dosage</subject><subject>apoptosis</subject><subject>Biological and medical sciences</subject><subject>cancer therapy</subject><subject>Chemotherapy, Adjuvant</subject><subject>Chromosome Deletion</subject><subject>Chromosomes, Human, Pair 17 - genetics</subject><subject>Fever</subject><subject>Fluorouracil - administration & dosage</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Genes, p53 - genetics</subject><subject>Heterozygote</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>p53</subject><subject>Point Mutation</subject><subject>Polymerase Chain Reaction - methods</subject><subject>Polymorphism, Single-Stranded Conformational</subject><subject>Radiotherapy, Adjuvant</subject><subject>Rectal Neoplasms - drug therapy</subject><subject>Rectal Neoplasms - genetics</subject><subject>Rectal Neoplasms - radiotherapy</subject><subject>Rectal Neoplasms - surgery</subject><subject>Rectal Neoplasms - therapy</subject><subject>sensitivity</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Suppositories</subject><subject>Tumors</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUGP0zAQhSMEWsrCT0DyAYndQ4odx07SRUirAqV0RQ8FwW3kOmNqNqmDnQK98stxaFUOIHyxPDP-5um9JLlidMwozZ5drObT-SWjlUwrWpUXrKoko5eST7LnZTGZXM9fpm9XS_6Cj-l4urzK0sWdZHSav5uMIiVL86Ki95MHIXyhlEZEfpaclfEUVTVKfnaCk8-4RdLuetVbtyU2kK3rSW096r7ZE4-N6rEmvSP9rnXealurhqAxsR-IM6Tz6Dr08fs3JF7V1ukNtm6zj8V-g761igy36vbEOE8GcCRotdXow8PknlFNwEfH-zz58PrV--mb9GY5m0-vb1Kdi4KnWAqljFJ5XJtzWStkmrG1pGK9NjSnWgitEEVWaWG04bxcSymwqLDmZVkpfp48PXA7777uMPTQ2qCxadQW3S5AIfLoCWMyTq4Ok9q7EDwa6Lxtld8DozBEAzBEA4PVMFgNh2hAcsigLABiNDBEAxwoTJexuojUx8f9u3WL9Yl5zCL2nxz7KmjVGB_tseE0luVFkTH6R9x32-D-L2X_F_YPXb_fkZoeqDb0-ONEVf4WZMELAR_fzUBwkX-SqwXM-C89I8iP</recordid><startdate>199610</startdate><enddate>199610</enddate><creator>Ichikawa, Daisuke</creator><creator>Yamaguchi, Toshiharu</creator><creator>Shirasu, Morio</creator><creator>Kitamura, Kazuya</creator><creator>Inazawa, Johji</creator><creator>Abe, Tatsuo</creator><creator>Takahashi, Toshio</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope></search><sort><creationdate>199610</creationdate><title>p53 gene mutation is not directly related to tumoricidal effects of preoperative radiochemohyperthermia therapy for rectal cancers</title><author>Ichikawa, Daisuke ; Yamaguchi, Toshiharu ; Shirasu, Morio ; Kitamura, Kazuya ; Inazawa, Johji ; Abe, Tatsuo ; Takahashi, Toshio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4573-e85aafaa4fec436dae1c11b605bbf040c55caee529c5fcf338b665e79ed3889a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Alleles</topic><topic>Antimetabolites, Antineoplastic - administration & dosage</topic><topic>apoptosis</topic><topic>Biological and medical sciences</topic><topic>cancer therapy</topic><topic>Chemotherapy, Adjuvant</topic><topic>Chromosome Deletion</topic><topic>Chromosomes, Human, Pair 17 - genetics</topic><topic>Fever</topic><topic>Fluorouracil - administration & dosage</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Genes, p53 - genetics</topic><topic>Heterozygote</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>p53</topic><topic>Point Mutation</topic><topic>Polymerase Chain Reaction - methods</topic><topic>Polymorphism, Single-Stranded Conformational</topic><topic>Radiotherapy, Adjuvant</topic><topic>Rectal Neoplasms - drug therapy</topic><topic>Rectal Neoplasms - genetics</topic><topic>Rectal Neoplasms - radiotherapy</topic><topic>Rectal Neoplasms - surgery</topic><topic>Rectal Neoplasms - therapy</topic><topic>sensitivity</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Suppositories</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ichikawa, Daisuke</creatorcontrib><creatorcontrib>Yamaguchi, Toshiharu</creatorcontrib><creatorcontrib>Shirasu, Morio</creatorcontrib><creatorcontrib>Kitamura, Kazuya</creatorcontrib><creatorcontrib>Inazawa, Johji</creatorcontrib><creatorcontrib>Abe, Tatsuo</creatorcontrib><creatorcontrib>Takahashi, Toshio</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ichikawa, Daisuke</au><au>Yamaguchi, Toshiharu</au><au>Shirasu, Morio</au><au>Kitamura, Kazuya</au><au>Inazawa, Johji</au><au>Abe, Tatsuo</au><au>Takahashi, Toshio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>p53 gene mutation is not directly related to tumoricidal effects of preoperative radiochemohyperthermia therapy for rectal cancers</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J. Surg. Oncol</addtitle><date>1996-10</date><risdate>1996</risdate><volume>63</volume><issue>2</issue><spage>87</spage><epage>90</epage><pages>87-90</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><coden>JSONAU</coden><abstract>Background
Several studies have recently demonstrated that apoptosis of cancer cells is triggered by diverse adjuvant cancer therapies and the induction of apoptosis correlates with the sensitivity of the primary tumor to such therapies.
Methods
We investigated the factors modulating adjuvant cancer therapies by examining p53 gene mutations and chromosome 17p allelic losses in 15 rectal cancers treated by a preoperative combined therapy consisting of radiation, intraluminal hyperthermia and 5‐fluorouracil suppositories.
Results
The point mutations were detected in 7 of 15 (46.7%) tumors by single‐stranded conformational polymorphism and direct sequencing. Allelic losses at chromosome 17p were also detected in 7 of 15 (46.7%) tumors by dinucleotide‐repeat polymorphisms. There was no correlation between p53 gene abnormalities and the preoperative tumoricidal effect of the therapy.
Conclusions
We conclude that p53 gene abnormalities do not directly increase resistance to the combined adjuvant therapy. © 1996 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>8888799</pmid><doi>10.1002/(SICI)1096-9098(199610)63:2<87::AID-JSO3>3.0.CO;2-K</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of surgical oncology, 1996-10, Vol.63 (2), p.87-90 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Alleles Antimetabolites, Antineoplastic - administration & dosage apoptosis Biological and medical sciences cancer therapy Chemotherapy, Adjuvant Chromosome Deletion Chromosomes, Human, Pair 17 - genetics Fever Fluorouracil - administration & dosage Gastroenterology. Liver. Pancreas. Abdomen Genes, p53 - genetics Heterozygote Humans Medical sciences p53 Point Mutation Polymerase Chain Reaction - methods Polymorphism, Single-Stranded Conformational Radiotherapy, Adjuvant Rectal Neoplasms - drug therapy Rectal Neoplasms - genetics Rectal Neoplasms - radiotherapy Rectal Neoplasms - surgery Rectal Neoplasms - therapy sensitivity Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Suppositories Tumors |
| title | p53 gene mutation is not directly related to tumoricidal effects of preoperative radiochemohyperthermia therapy for rectal cancers |
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