Loop-Tryptophan Human Purine Nucleoside Phosphorylase Reveals Submillisecond Protein Dynamics

Human PNP is a homotrimer containing three tryptophan residues at positions 16, 94, and 178, all remote from the catalytic site. The catalytic sites of PNP are located near the subunit−subunit interfaces where F159 is a catalytic site residue donated from an adjacent subunit. F159 covers the top (β)...

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Veröffentlicht in:	Biochemistry (Easton) 2009-04, Vol.48 (16), p.3658-3668
Hauptverfasser:	Ghanem, Mahmoud, Zhadin, Nickolay, Callender, Robert, Schramm, Vern L
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalytic Domain Humans Kinetics Models, Molecular Molecular Structure Mutagenesis, Site-Directed Protein Binding Protein Conformation Protein Subunits - chemistry Protein Subunits - genetics Protein Subunits - metabolism Purine Nucleosides - chemistry Purine Nucleosides - metabolism Purine-Nucleoside Phosphorylase - chemistry Purine-Nucleoside Phosphorylase - genetics Purine-Nucleoside Phosphorylase - metabolism Pyrimidinones - chemistry Pyrimidinones - metabolism Thermodynamics Tryptophan - chemistry
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