Histone deacetylase inhibitor FR235222 sensitizes human prostate adenocarcinoma cells to apoptosis through up-regulation of Annexin A1

Abstract The reduction of Annexin A1 (ANXA1) expression, commonly associated with prostate cancer, could be due to elevated activity of histone deacetylases. We have investigated the mechanisms of apoptotic effects of FR235222 in LNCaP cell line and the role of ANXA1. We showed that treatment with F...

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Veröffentlicht in:	Cancer letters 2010-09, Vol.295 (1), p.85-91
Hauptverfasser:	D’Acunto, Cosimo Walter, Fontanella, Bianca, Rodriquez, Manuela, Taddei, Maurizio, Parente, Luca, Petrella, Antonello
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Adenocarcinoma - metabolism Adenocarcinoma - pathology Annexin A1 Annexin A1 - genetics Annexin A1 - metabolism Apoptosis Apoptosis - drug effects Blotting, Western Caspase 3 - metabolism Cell growth Cell Line, Tumor Chromatin Hematology, Oncology and Palliative Medicine Histone deacetylase inhibitors Histone Deacetylase Inhibitors - pharmacology Histone Deacetylases - metabolism Histones - metabolism Humans Kinases Male Peptides, Cyclic - pharmacology Prostate cancer Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology RNA, Small Interfering - genetics Up-Regulation
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