The V617F JAK2 mutation and the myeloproliferative disorders

The discovery this year of a single mutation in the Janus Kinase (JAK)‐2 gene in a high percentage of cases of polycythaemia vera (PV), essential thrombocythaemia (ET) and myelofibrosis suggests that it maybe the underlying molecular mechanism for these disorders. Different approaches from the inhib...

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Veröffentlicht in:	Hematological oncology 2005-09, Vol.23 (3-4), p.91-93
Hauptverfasser:	Percy, Melanie J, McMullin, Mary Frances
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino Acid Substitution ARMS-PCR Chromosomes, Human, Pair 9 - genetics DNA Mutational Analysis Enzyme Activation - genetics Heterozygote Humans JAK2 Janus Kinase 2 mutation myeloproliferative disorders Myeloproliferative Disorders - genetics Phenylalanine - genetics Point Mutation polycythemia vera Protein-Tyrosine Kinases - genetics Proto-Oncogene Proteins - genetics Valine - genetics
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