Change of the cell cycle after flutamide treatment in prostate cancer cells and its molecular mechanism

Aim: To explore the effect of androgen receptor (AR) on the expression of the cell cycle‐related genes, such as CDKN1A and BTG1, in prostate cancer cell line LNCaP. Methods: After AR antagonist flutamide treatment and confirmation of its effect by phase contrast microscope and flow cytometry, the di...

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Veröffentlicht in:	Asian journal of andrology 2005-12, Vol.7 (4), p.375-380
Hauptverfasser:	Wang, Yong, Shao, Chen, Shi, Chang‐Hong, Zhang, Lei, Yue, Hong‐Hong, Wang, Peng‐Fei, Yang, Bo, Zhang, Yun‐Tao, Liu, Fan, Qin, Wei‐Jun, Wang, He, Shao, Guo‐Xing
Format:	Artikel
Sprache:	eng
Schlagworte:	androgen receptor Androgen Receptor Antagonists Antineoplastic Agents, Hormonal - pharmacology BTG1 CDKN1A Cell Cycle - drug effects Cell Cycle - genetics cell cycle genes Cell Line, Tumor Cyclin-Dependent Kinase Inhibitor p21 - genetics flutamide Flutamide - pharmacology Gene Expression Regulation, Neoplastic - drug effects Humans LNCaP Male Neoplasm Proteins - genetics Oligonucleotide Array Sequence Analysis p21 prostate cancer Prostate-Specific Antigen - genetics Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis
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