Engineering of stable bispecific antibodies targeting IL-17A and IL-23

Bispecific antibodies (bsAbs) present an attractive opportunity to combine the additive and potentially synergistic effects exhibited by combinations of monoclonal antibodies (mAbs). Current challenges for engineering bsAbs include retention of the binding affinity of the parent mAb or antibody frag...

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Veröffentlicht in:	Protein engineering, design and selection design and selection, 2010-03, Vol.23 (3), p.115-127
Hauptverfasser:	Mabry, Robert, Lewis, Katherine E., Moore, Margaret, McKernan, Patricia A., Bukowski, Thomas R., Bontadelli, Kristen, Brender, Ty, Okada, Shannon, Lum, Karen, West, James, Kuijper, Joseph L., Ardourel, Dan, Franke, Secil, Lockwood, Luann, Vu, Tuyen, Frank, Amanda, Appleby, Mark W., Wolf, Anitra, Reardon, Brian, Hamacher, Nels B., Stevens, Brenda, Lewis, Patsy, Lewis, Kenneth B., Gilbertson, Debra G., Lantry, Megan, Julien, Susan H., Ostrander, Craig, Chan, Chung, Byrnes-Blake, Kelly, Brody, Jennifer, Presnell, Scott, Meengs, Brent, Levin, Steven D., Snavely, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Bispecific - chemistry Antibodies, Bispecific - genetics Antibodies, Bispecific - immunology Antibodies, Bispecific - pharmacokinetics Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology antibody Antibody Affinity bispecific Databases, Protein Escherichia coli - genetics Female Half-Life Humans IL-17A IL-23 Interleukin-17 - immunology Interleukin-23 - immunology Kinetics Mice Protein Engineering Protein Stability scFv Single-Chain Antibodies - chemistry Single-Chain Antibodies - genetics Single-Chain Antibodies - immunology Single-Chain Antibodies - metabolism
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