Clonal resistance analyses of HIV type-1 after failure of therapy with didanosine, lamivudine and tenofovir

Background The rapid failure of initial therapy with combinations of nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) that exclude zidovudine has not been fully explained by standard virus population analyses of HIV type-1 (HIV-1) drug resistance. We therefore investigated HIV-1 genoty...

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Veröffentlicht in:	Antiviral therapy 2010-01, Vol.15 (3), p.437-441
Hauptverfasser:	Barnas, Douglas, Koontz, Dianna, Bazmi, Holly, Bixby, Christian, Jemsek, Joseph, Mellors, John W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - administration & dosage Adenine - analogs & derivatives Adenine - pharmacology Adenine - therapeutic use Anti-HIV Agents - administration & dosage Anti-HIV Agents - pharmacology Anti-HIV Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Didanosine - administration & dosage Didanosine - pharmacology Didanosine - therapeutic use Drug Resistance, Viral - genetics Drug Therapy, Combination Genome, Viral - genetics Genotype HIV Infections - drug therapy HIV Infections - virology HIV Reverse Transcriptase - genetics HIV Reverse Transcriptase - metabolism HIV-1 - drug effects HIV-1 - genetics Human immunodeficiency virus 1 Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Lamivudine - administration & dosage Lamivudine - pharmacology Lamivudine - therapeutic use Medical sciences Mutation Organophosphonates - administration & dosage Organophosphonates - pharmacology Organophosphonates - therapeutic use Pharmacology. Drug treatments Phenotype Recombination, Genetic Reverse Transcriptase Inhibitors - administration & dosage Reverse Transcriptase Inhibitors - pharmacology Reverse Transcriptase Inhibitors - therapeutic use Sequence Analysis, DNA Tenofovir Treatment Failure Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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