Epimutations and cancer predisposition: importance and mechanisms

Germline sequence mutations in tumour suppressor genes can cause cancer predisposition syndromes. More recently, epimutations have also been proposed to cause at least one such syndrome, hereditary non-polyposis colorectal cancer (HNPCC). ‘Epigenetic predisposition’, is defined as an inherited prope...

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Veröffentlicht in:	Current opinion in genetics & development 2010-06, Vol.20 (3), p.290-298
Hauptverfasser:	Hesson, Luke B, Hitchins, Megan P, Ward, Robyn L
Format:	Artikel
Sprache:	eng
Schlagworte:	Colorectal Neoplasms, Hereditary Nonpolyposis - genetics Epigenesis, Genetic Gene Dosage Genetic Predisposition to Disease - genetics Genome, Human - genetics Germ-Line Mutation Humans Medical Education Models, Genetic Neoplasms - genetics Polymorphism, Single Nucleotide
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