A complex karyotype including a t(2;11) in a paediatric ependymoma: case report and review of the literature
Ependymomas are glial tumours representing approximately 5–10% of all intracranial tumours and are the third most common primary brain tumour in childhood. Only a few karyotypic studies on paediatric ependymomas have been published and no specific chromosomal aberration has been specifically related...
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| Veröffentlicht in: | Journal of neuro-oncology 2010-08, Vol.99 (1), p.141-146 |
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| container_title | Journal of neuro-oncology |
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| creator | Aschero, Simona Vallero, Stefano Morra, Isabella Impera, Luciana Forni, Marco Sandri, Alessandro Basso, Maria E. Storlazzi, Clelia T. Giordano, Flavio Fidani, Paola De Ioris, Maria A. di Montezemolo, Luca Cordero |
| description | Ependymomas are glial tumours representing approximately 5–10% of all intracranial tumours and are the third most common primary brain tumour in childhood. Only a few karyotypic studies on paediatric ependymomas have been published and no specific chromosomal aberration has been specifically related to this type of cancer. We performed cytogenetic analysis of an ependymoma in an 11-year-old boy. Our patient showed a complex karyotype, characterized by a near-tetraploidy and a sole structural unbalanced aberration: der(2)t(2;11)(q11.2;q13.1), which has not been described before. We here discuss such cytogenetic findings, comparing our data with those reported in the literature. |
| doi_str_mv | 10.1007/s11060-009-0108-x |
| format | Article |
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Only a few karyotypic studies on paediatric ependymomas have been published and no specific chromosomal aberration has been specifically related to this type of cancer. We performed cytogenetic analysis of an ependymoma in an 11-year-old boy. Our patient showed a complex karyotype, characterized by a near-tetraploidy and a sole structural unbalanced aberration: der(2)t(2;11)(q11.2;q13.1), which has not been described before. We here discuss such cytogenetic findings, comparing our data with those reported in the literature.</description><identifier>ISSN: 0167-594X</identifier><identifier>EISSN: 1573-7373</identifier><identifier>DOI: 10.1007/s11060-009-0108-x</identifier><identifier>PMID: 20066474</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Brain Neoplasms - genetics ; Case Report ; Child ; Chromosome Aberrations ; Chromosomes, Human, Pair 11 ; Ependymoma - genetics ; Humans ; Karyotyping - methods ; Male ; Medicine ; Medicine & Public Health ; Neurology ; Oncology ; Translocation, Genetic</subject><ispartof>Journal of neuro-oncology, 2010-08, Vol.99 (1), p.141-146</ispartof><rights>Springer Science+Business Media, LLC. 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c354t-12e6b6a03d55bea81294b1644933f41a66e0ec0d2093ec0a1acdbb32997cd38e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11060-009-0108-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11060-009-0108-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20066474$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aschero, Simona</creatorcontrib><creatorcontrib>Vallero, Stefano</creatorcontrib><creatorcontrib>Morra, Isabella</creatorcontrib><creatorcontrib>Impera, Luciana</creatorcontrib><creatorcontrib>Forni, Marco</creatorcontrib><creatorcontrib>Sandri, Alessandro</creatorcontrib><creatorcontrib>Basso, Maria E.</creatorcontrib><creatorcontrib>Storlazzi, Clelia T.</creatorcontrib><creatorcontrib>Giordano, Flavio</creatorcontrib><creatorcontrib>Fidani, Paola</creatorcontrib><creatorcontrib>De Ioris, Maria A.</creatorcontrib><creatorcontrib>di Montezemolo, Luca Cordero</creatorcontrib><title>A complex karyotype including a t(2;11) in a paediatric ependymoma: case report and review of the literature</title><title>Journal of neuro-oncology</title><addtitle>J Neurooncol</addtitle><addtitle>J Neurooncol</addtitle><description>Ependymomas are glial tumours representing approximately 5–10% of all intracranial tumours and are the third most common primary brain tumour in childhood. Only a few karyotypic studies on paediatric ependymomas have been published and no specific chromosomal aberration has been specifically related to this type of cancer. We performed cytogenetic analysis of an ependymoma in an 11-year-old boy. Our patient showed a complex karyotype, characterized by a near-tetraploidy and a sole structural unbalanced aberration: der(2)t(2;11)(q11.2;q13.1), which has not been described before. We here discuss such cytogenetic findings, comparing our data with those reported in the literature.</description><subject>Brain Neoplasms - genetics</subject><subject>Case Report</subject><subject>Child</subject><subject>Chromosome Aberrations</subject><subject>Chromosomes, Human, Pair 11</subject><subject>Ependymoma - genetics</subject><subject>Humans</subject><subject>Karyotyping - methods</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurology</subject><subject>Oncology</subject><subject>Translocation, Genetic</subject><issn>0167-594X</issn><issn>1573-7373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU2P1DAMhiMEYoeFH8AFRVyAQ8FO0mS6nFYrvqSVuIDELUoTz9KlbUqSwsy_J6tZQELi5MR-_Nryy9hjhJcIYF5lRNDQAHQNIGyb_R22wdbIxkgj77INoDZN26kvJ-xBztcAoIzE--xEAGitjNqw8Zz7OC0j7fk3lw6xHBbiw-zHNQzzFXe8PBevEV_UXP0sjsLgSho8p4XmcJji5M64d5l4oiWmwt0c6vPHQD953PHylfg4FEqurIkesns7N2Z6dBtP2ee3bz5dvG8uP777cHF-2XjZqtKgIN1rBzK0bU9ui6JTPWqlOil3Cp3WBOQhCOhkjQ6dD30vRdcZH-SW5Cl7dtRdUvy-Ui52GrKncXQzxTVb06qtAaHbSj79h7yOa5rrclaD1EIp01UIj5BPMedEO7ukYarXsgj2xgh7NMJWI-yNEXZfe57cCq_9ROFPx-_LV0AcgVxL8xWlv5P_r_oLoOCTCA</recordid><startdate>20100801</startdate><enddate>20100801</enddate><creator>Aschero, Simona</creator><creator>Vallero, Stefano</creator><creator>Morra, Isabella</creator><creator>Impera, Luciana</creator><creator>Forni, Marco</creator><creator>Sandri, Alessandro</creator><creator>Basso, Maria E.</creator><creator>Storlazzi, Clelia T.</creator><creator>Giordano, Flavio</creator><creator>Fidani, Paola</creator><creator>De Ioris, Maria A.</creator><creator>di Montezemolo, Luca Cordero</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20100801</creationdate><title>A complex karyotype including a t(2;11) in a paediatric ependymoma: case report and review of the literature</title><author>Aschero, Simona ; 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| subjects | Brain Neoplasms - genetics Case Report Child Chromosome Aberrations Chromosomes, Human, Pair 11 Ependymoma - genetics Humans Karyotyping - methods Male Medicine Medicine & Public Health Neurology Oncology Translocation, Genetic |
| title | A complex karyotype including a t(2;11) in a paediatric ependymoma: case report and review of the literature |
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