Hypoxia increases Sca-1/CD44 co-expression in murine mesenchymal stem cells and enhances their adipogenic differentiation potential

Mesenchymal stem cells (MSCs) are usually cultured under normoxic conditions (21% oxygen). However, in vivo, the physiological “niches” for MSCs have a much lower oxygen tension. Because of their plasticity, stem cells are particularly sensitive to their environments, and oxygen tension is one devel...

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Veröffentlicht in:	Cell and tissue research 2010-07, Vol.341 (1), p.111-120
Hauptverfasser:	Valorani, M. G, Germani, A, Otto, W. R, Harper, L, Biddle, A, Khoo, C. P, Lin, W. R, Hawa, M. I, Tropel, P, Patrizi, M. P, Pozzilli, P, Alison, M. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipogenesis adipose tissue Adipose Tissue - cytology Adipose tissues Animals Ataxin-1 Ataxins Biomarkers - metabolism Biomedical and Life Sciences Biomedicine Body fat CD44 Cell culture (Mouse) Cell Cycle Cell Hypoxia Cell Proliferation Cell Survival Cells Cells, Cultured Cellular biology Differentiation Gene expression Human Genetics Hyaluronan Receptors - metabolism Hypoxia Lipoprotein lipase Male Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Mice mMSCs Molecular Medicine Nerve Tissue Proteins - metabolism Nuclear Proteins - metabolism Protein binding Proteomics Regular Article Rodents Sca-1 Stem cells
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